Radiation therapy and stereotactic radiosurgery for the treatment of Cushings disease: An evidence-based review

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 17, Issue 4, 2010, Pages 356-364

  Starke, Robert M ^a   Williams, Brian J ^a   Vance, Mary Lee ^b   Sheehan, Jason P ^a  

^a Department of Neurological Surgery ^*  (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cushings disease; gamma knife; radiation therapy; radiosurgery

Indexed keywords

CANCER CONTROL; CAROTID ARTERY INJURY; CEREBROVASCULAR DISEASE; CUSHING DISEASE; GAMMA KNIFE RADIOSURGERY; HORMONE DEFICIENCY; HUMAN; HYPOPHYSIS ADENOMA; HYPOPHYSIS DISEASE; HYPOPITUITARISM; PEER REVIEW; PREOPERATIVE EVALUATION; PROTON THERAPY; RADIATION DOSE; REVIEW; STEREOTACTIC RADIOSURGERY; TUMOR VOLUME; VISUAL DISORDER; ACTH-SECRETING PITUITARY ADENOMA; ADENOMA; EVIDENCE BASED PRACTICE; PITUITARY ACTH HYPERSECRETION; PREOPERATIVE CARE; PROCEDURES; RADIOSURGERY; TREATMENT OUTCOME; TRENDS;

ACTH-SECRETING PITUITARY ADENOMA; ADENOMA; EVIDENCE-BASED PRACTICE; HUMANS; PITUITARY ACTH HYPERSECRETION; PREOPERATIVE CARE; RADIOSURGERY; RADIOTHERAPY; TREATMENT OUTCOME;

EID: 77955769086     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32833ab069     Document Type: Review

References (95)

1. Lindholm J, Juul S, Jorgensen JO, et al. Incidence and late prognosis of Cushings syndrome: a population-based study. J Clin Endocrinol Metab 2001; 86:117-123.
2. Dekkers OM, Biermasz NR, Pereira AM, et al. Mortality in patients treated for Cushings disease is increased, compared with patients treated for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 2007; 92:976-981.
3. Meij BP, Lopes MB, Ellegala DB, et al. The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery. J Neurosurg 2002; 96:195-208.
4. Shaffi OM, Wrightson P. Dural invasion by pituitary tumours. N Z Med J 1975; 81:386-390.
5. Knappe UJ, Ludecke DK. Persistent and recurrent hypercortisolism after transsphenoidal surgery for Cushings disease. Acta Neurochir Suppl 1996; 65:31-34.
6. Mampalam TJ, Tyrrell JB, Wilson CB. Transsphenoidal microsurgery for Cushings disease. A report of 216 cases. Ann Intern Med 1988; 109:487-493.
7. Laws ER Jr, Vance ML. Radiosurgery for pituitary tumors and craniopharyngiomas. Neurosurg Clin N Am 1999; 10:327-336.
8. Laws ER, Jr., Ebersold M, DG P. The results of transsphenoidal surgery in specific clinical entities. In: Management of Pituitary Adenomas and Related Lesions with Emphasis on Transsphenoidal Microsurgery. In: Laws ER, Jr., Randall R, EB K, editors. New York: Appleton-Century-Crofts; 1982. pp. 277-305.
9. Friedman RB, Oldfield EH, Nieman LK, et al. Repeat transsphenoidal surgery for Cushings disease. J Neurosurg 1989; 71:520-527.
10. Chandler WF, Schteingart DE, Lloyd RV, et al. Surgical treatment of Cushings disease. J Neurosurg 1987; 66:204-212.
11. Rollin GA, Ferreira NP, Junges M, et al. Dynamics of serum cortisol levels after transsphenoidal surgery in a cohort of patients with Cushings disease. J Clin Endocrinol Metab 2004; 89:1131-1139.
12. Hofmann BM, Hlavac M, Martinez R, et al. Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35 years. J Neurosurg 2008; 108:9-18.
13. Atkinson AB, Kennedy A, Wiggam MI, et al. Long-term remission rates after pituitary surgery for Cushings disease: the need for long-term surveillance. Clin Endocrinol (Oxf) 2005; 63:549-559.
14. Castinetti F, Nagai M, Dufour H, et al. Gamma knife radiosurgery is a successful adjunctive treatment in Cushings disease. Eur J Endocrinol 2007; 156:91-98.
15. Feigl GC, Bonelli CM, Berghold A, et al. Effects of gamma knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg 2002; 97 (5 Suppl): 415-421.
16. Ganz JC, Backlund EO, Thorsen FA. The effects of Gamma Knife surgery of pituitary adenomas on tumor growth and endocrinopathies. Stereotact Funct Neurosurg 1993; 61 (Suppl 1):30-37.
17. Hayashi M, Izawa M, Hiyama H, et al. Gamma Knife radiosurgery for pituitary adenomas. Stereotact Funct Neurosurg 1999; 72 (Suppl 1):111-118.
18. Hoybye C, Grenback E, Rahn T, et al. Adrenocorticotropic hormone-producing pituitary tumors: 12- to 22-year follow-up after treatment with stereotactic radiosurgery. Neurosurgery 2001; 49:284-291; discussion 291-1282
19. Inoue HK, Kohga H, Hirato M, et al. Pituitary adenomas treated by microsurgery with or without Gamma Knife surgery: experience in 122 cases. Stereotact Funct Neurosurg 1999; 72 (Suppl 1):125-131.
20. Izawa M, Hayashi M, Nakaya K, et al. Gamma knife radiosurgery for pituitary adenomas. J Neurosurg 2000; 93 (Suppl 3):19-22.
21. Jagannathan J, Sheehan JP, Pouratian N, et al. Gamma knife surgery for Cushings disease. J Neurosurg 2007; 106:980-987.
22. Kobayashi T, Kida Y, Mori Y. Gamma knife radiosurgery in the treatment of Cushing disease: long-termresults. J Neurosurg 2002; 97 (5 Suppl):422-428.
23. Levy RP, Fabrikant JI, Frankel KA, et al. Heavy-charged-particle radiosurgery of the pituitary gland: clinical results of 840 patients. Stereotact Funct Neurosurg 1991; 57 (1-2):22-35.
24. Lim YL, Leem W, Kim TS, et al. Four years experiences in the treatment of pituitary adenomas with gamma knife radiosurgery. Stereotact Funct Neurosurg 1998; 70 (Suppl 1):95-109.
25. Martinez R, Bravo G, Burzaco J, et al. Pituitary tumors and gamma knife surgery. Clinical experience with more than two years of follow-up. Stereotact Funct Neurosurg 1998; 70 (Suppl 1):110-118.
26. Mitsumori M, Shrieve DC, Alexander E 3rd, et al. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys 1998; 42:573-580.
27. Mokry M, Ramschak-Schwarzer S, Simbrunner J, et al. A six year experience with the postoperative radiosurgical management of pituitary adenomas. Stereotact Funct Neurosurg 1999; 72 (Suppl 1):88-100.
28. Morange-Ramos I, Regis J, Dufour H, et al. Gamma-knife surgery for secreting pituitary adenomas. Acta Neurochir (Wien) 1998; 140:437-443.
29. Petit JH, Biller BM, Yock TI, et al. Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas. J Clin Endocrinol Metab 2008; 93:393-399.
30. Pollock BE, Brown PD, Nippoldt TB, et al. Pituitary tumor type affects the chance of biochemical remission after radiosurgery of hormone-secreting pituitary adenomas. Neurosurgery 2008; 62:1271-1276; discussion 1276-1278.
31. Pollock BE, Nippoldt TB, Stafford SL, et al. Results of stereotactic radiosurgery in patients with hormone-producing pituitary adenomas: factors associated with endocrine normalization. J Neurosurg 2002; 97:525-530.
32. Pollock BE, Young WF Jr. Stereotactic radiosurgery for patients with ACTHproducing pituitary adenomas after prior adrenalectomy. Int J Radiat Oncol Biol Phys 2002; 54:839-841.
33. Sheehan JM, Vance ML, Sheehan JP, et al. Radiosurgery for Cushings disease after failed transsphenoidal surgery. J Neurosurg 2000; 93:738-742.
34. Shin M, Kurita H, Sasaki T, et al. Stereotactic radiosurgery for pituitary adenoma invading the cavernous sinus. J Neurosurg 2000; 93 (Suppl 3):2-5.
35. Witt TC, Kondziolka D, Flickinger JC, et al. Gamma knife radiosurgery for pituitary tumors. Gamma Knife Brain Surgery Progress in Neurological Surgery. In: Lunsford LD, Kondziolka D, Flickinger J, editors. 14. Basel: Karger; 1998. pp. 114-127.
36. Yoon SC, Suh TS, Jang HS, et al. Clinical results of 24 pituitary macroadenomas with linac-based stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 1998; 41:849-853.
37. Petrovich Z, Yu C, Giannotta SL, et al. Gamma knife radiosurgery for pituitary adenoma: early results. Neurosurgery 2003; 53:51-59; discussion 59-61.
38. Kong DS, Lee JI, Lim do H, et al. The efficacy of fractionated radiotherapy and stereotactic radiosurgery for pituitary adenomas: long-term results of 125 consecutive patients treated in a single institution. Cancer 2007; 110:854-860.
39. Choi JY, Chang JH, Chang JW, et al. Radiological and hormonal responses of functioning pituitary adenomas after gamma knife radiosurgery. Yonsei Med J 2003; 44:602-607.
40. Colin P, Jovenin N, Delemer B, et al. Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients. Int J Radiat Oncol Biol Phys 2005; 62:333-341.
41. Devin JK, Allen GS, Cmelak AJ, et al. The efficacy of linear accelerator radiosurgery in the management of patients with Cushings disease. Stereotact Funct Neurosurg 2004; 82 (5-6):254-262.
42. Kajiwara K, Saito K, Yoshikawa K, et al. Image-guided stereotactic radiosurgery with the CyberKnife for pituitary adenomas. Minim Invasive Neurosurg 2005; 48:91-96.
43. Wong GK, Leung CH, Chiu KW, et al. LINAC radiosurgery in recurrent Cushings disease after transsphenoidal surgery: a series of 5 cases. Minim Invasive Neurosurg 2003; 46:327-330.
44. Estrada J, Boronat M, Mielgo M, et al. The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushings disease. N Engl J Med 1997; 336:172-177.
45. Howlett TA, Plowman PN, Wass JA, et al. Megavoltage pituitary irradiation in the management of Cushings disease and Nelsons syndrome: long-term follow-up. Clin Endocrinol (Oxf) 1989; 31:309-323.
46. Littley MD, Shalet SM, Beardwell CG, et al. Long-term follow-up of low-dose external pituitary irradiation for Cushings disease. Clin Endocrinol (Oxf) 1990; 33:445-455.
47. Minniti G, Osti M, Jaffrain-Rea ML, et al. Long-term follow-up results of postoperative radiation therapy for Cushings disease. J Neurooncol 2007; 84:79-84.
48. Murayama M, Yasuda K, Minamori Y, et al. Long term follow-up of Cushings disease treated with reserpine and pituitary irradiation. J Clin Endocrinol Metab 1992; 75:935-942.
49. Storr HL, Plowman PN, Carroll PV, et al. Clinical and endocrine responses to pituitary radiotherapy in pediatric Cushings disease: an effective second-line treatment. J Clin Endocrinol Metab 2003; 88:34-37.
50. Tsang RW, Brierley JD, Panzarella T, et al. Role of radiation therapy in clinical hormonally-active pituitary adenomas. Radiother Oncol 1996; 41:45-53.
51. Laws ER, Sheehan JP. Pituitary surgery: a modern approach.. Basel: Karger; 2006.
52. Laws ER, Thapar K. Recurrent pituitary adenomas. Churchill-Livingtone, Edninburgh; 1996.
53. Kanter AS, Diallo AO, Jane JA Jr, et al. Single-center experience with pediatric Cushings disease. J Neurosurg 2005; 103 (5 Suppl):413-420.
54. Jagannathan J, Dumont AS, Jane JA Jr, et al. Pediatric sellar tumors: diagnostic procedures and management. Neurosurg Focus 2005; 18 (6A):E6.
55. Jagannathan J, Sheehan JP, Jane JA Jr. Evaluation and management of Cushing syndrome in cases of negative sellar magnetic resonance imaging. Neurosurg Focus 2007; 23:E3.
56. Jehle S, Walsh JE, Freda PU, et al. Selective use of bilateral inferior petrosal sinus sampling in patients with adrenocorticotropin-dependent Cushings syndrome prior to transsphenoidal surgery. J Clin Endocrinol Metab 2008; 93:4624-4632.
57. Barnett GH, Linskey ME, Adler JR, et al. Stereotactic radiosurgery: an organized neurosurgery-sanctioned definition. J Neurosurg 2007; 106:1-5.
58. Friedman WA, Foote KD. Linear accelerator radiosurgery in the management of brain tumours. Ann Med 2000; 32:64-80.
59. Lyman JT, Phillips MH, Frankel KA, et al. Radiation physics for particle beam radiosurgery. Neurosurg Clin N Am 1992; 3:1-8.
60. Labeur M, Arzt E, Stalla GK, et al. New perspectives in the treatment of Cushings syndrome. Curr Drug Targets Immune Endocr Metabol Disord 2004; 4:335-342.
61. Arnaldi G, Angeli A, Atkinson AB, et al. Diagnosis and complications of Cushings syndrome: a consensus statement. J Clin Endocrinol Metab 2003; 88:5593-5602.
62. Minniti G, Brada M. Radiotherapy and radiosurgery for Cushings disease. Arq Bras Endocrinol Metabol 2007; 51:1373-1380.
63. Abe T, Yamamoto M, Taniyama M, et al. Early palliation of oculomotor nerve palsy following gamma knife radiosurgery for pituitary adenoma. Eur Neurol 2002; 47:61-63.
64. Chen JC, Giannotta SL, Yu C, et al. Radiosurgical management of benign cavernous sinus tumors: dose profiles and acute complications. Neurosurgery 2001; 48:1022-1030; discussion 1030-11022
65. Losa M, Valle M, Mortini P, et al. Gamma knife surgery for treatment of residual nonfunctioning pituitary adenomas after surgical debulking. J Neurosurg 2004; 100:438-444.
66. Sheehan JP, Kondziolka D, Flickinger J, et al. Radiosurgery for residual or recurrent nonfunctioning pituitary adenoma. J Neurosurg 2002; 97 (5 Suppl): 408-414.
67. Minniti G, Traish D, Ashley S, et al. Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years. J Clin Endocrinol Metab 2005; 90:800-804.
68. Brada M, Ashley S, Ford D, et al. Cerebrovascular mortality in patients with pituitary adenoma. Clin Endocrinol (Oxf) 2002; 57:713-717.
69. Kim SH, Huh R, Chang JW, et al. Gamma Knife radiosurgery for functioning pituitary adenomas. Stereotact Funct Neurosurg 1999; 72 (Suppl 1):101-110.
70. Ganz JC. Gamma knife radiosurgery and its possible relationship to malignancy: a review. J Neurosurg 2002; 97 (5 Suppl):644-652.
71. Witt TC. Stereotactic radiosurgery for pituitary tumors. Neurosurg Focus 2003; 14:e10.
72. Laws ER, Vance ML, Thapar K. Pituitary surgery for the management of acromegaly. Horm Res 2000; 53 (Suppl 3):71-75.
73. Zhang N, Pan L, Wang EM, et al. Radiosurgery for growth hormone-producing pituitary adenomas. J Neurosurg 2000; 93 (Suppl 3):6-9.
74. Kim MS, Lee SI, Sim JH. Gamma Knife radiosurgery for functioning pituitary microadenoma. Stereotact Funct Neurosurg 1999; 72 (Suppl 1):119-124.
75. Landolt AM, Haller D, Lomax N, et al. Octreotide may act as a radioprotective agent in acromegaly. J Clin Endocrinol Metab 2000; 85:1287-1289.
76. Landolt AM, Lomax N. Gamma knife radiosurgery for prolactinomas. J Neurosurg 2000; 93 (Suppl 3):14-18.
77. Pan L, Zhang N, Wang EM, et al. Gamma knife radiosurgery as a primary treatment for prolactinomas. J Neurosurg 2000; 93 (Suppl 3):10-13. (Pubitemid 32799537)
78. Jagannathan J, Kanter AS, Olson C, et al. Applications of radiotherapy and radiosurgery in the management of pediatric Cushings disease: a review of the literature and our experience. J Neurooncol 2008; 90:117-124.
79. Jane JA Jr, Laws ER Jr. The surgical management of pituitary adenomas in a series of 3,093 patients. J Am Coll Surg 2001; 193:651-659.
80. Mingione V, Yen CP, Vance ML, et al. Gamma surgery in the treatment of nonsecretory pituitary macroadenoma. J Neurosurg 2006; 104:876-883.
81. Mauermann WJ, Sheehan JP, Chernavvsky DR, et al.Gamma Knife surgery for adrenocorticotropic hormone-producing pituitary adenomas after bilateral adrenalectomy. J Neurosurg 2007; 106:988-993.
82. Jane JA Jr, Vance ML, Woodburn CJ, et al. Stereotactic radiosurgery for hypersecreting pituitary tumors: part of a multimodality approach. Neurosurg Focus 2003; 14:e12.
83. Pollock BE, Carpenter PC. Stereotactic radiosurgery as an alternative to fractionated radiotherapy for patients with recurrent or residual nonfunctioning pituitary adenomas. Neurosurgery 2003; 53:1086-1091; discussion 1091-11084
84. Sheehan JM, Lopes MB, Sheehan JP, et al. Results of transsphenoidal surgery for Cushings disease in patients with no histologically confirmed tumor. Neurosurgery 2000; 47:33-36; discussion 37-39.
85. Stafford SL, Pollock BE, Leavitt JA, et al. A study on the radiation tolerance of the optic nerves and chiasm after stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 2003; 55:1177-1181.
86. Ove R, Kelman S, Amin PP, et al. Preservation of visual fields after peri-sellar gamma-knife radiosurgery. Int J Cancer 2000; 90:343-350.
87. Tishler RB, Loeffler JS, Lunsford LD, et al. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys 1993; 27:215-221.
88. Girkin CA, Comey CH, Lunsford LD, et al. Radiation optic neuropathy after stereotactic radiosurgery. Ophthalmology 1997; 104:1634-1643.
89. Leber KA, Bergloff J, Pendl G. Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg 1998; 88:43-50.
90. Rodriguez O, Mateos B, de la Pedraja R, et al. Postoperative follow-up of pituitary adenomas after trans-sphenoidal resection: MRI and clinical correlation. Neuroradiology 1996; 38:747-754.
91. Lundstrom M, Frisen L. Atrophy of optic nerve fibres in compression of the chiasm. Degree and distribution of ophthalmoscopic changes. Acta Ophthalmol (Copenh) 1976; 54:623-640.
92. Muron T, Rocher FP, Sentenac I, et al. Stereotactic radiosurgery. Preliminary experience of a team of Lyon. Ann Med Interne (Paris) 1993; 144:9-14.
93. Muramatsu J, Yoshida M, Shioura H, et al. Clinical results of LINAC-based stereotactic radiosurgery for pituitary adenoma. Nippon Igaku Hoshasen Gakkai Zasshi 2003; 63:225-230.
94. Rowe J, Grainger A, Walton L, et al. Risk of malignancy after gamma knife stereotactic radiosurgery. Neurosurgery 2007; 60:60-65; discussion 65-66.
95. Assie G, Bahurel H, Coste J, et al. Corticotroph tumor progression after adrenalectomy in Cushings Disease: a reappraisal of Nelsons Syndrome. J Clin Endocrinol Metab 2007; 92:172-179.