Method of balanced adjustment in testing co-primary endpoints

Statistics in Medicine

Volumn 29, Issue 19, 2010, Pages 2055-2066

  Kordzakhia, George ^a   Siddiqui, Ohidul ^a   Huque, Mohammad F ^a,b  

^a CDER   (United States)

^b GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

Clinical trials; Co primary endpoints; Multiplicity

Indexed keywords

ARTICLE; FALSE POSITIVE RESULT; MEASUREMENT ERROR; STATISTICAL ANALYSIS; STATISTICAL MODEL;

BIAS (EPIDEMIOLOGY); CLINICAL TRIALS AS TOPIC; ENDPOINT DETERMINATION; EPIDEMIOLOGIC RESEARCH DESIGN; HUMANS;

EID: 77955734898     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.3950     Document Type: Article

References (4)

1. Patel HI. Comparison of treatments in a combination therapy trial. Journal of Biopharmaceutical Statistics 1991; 1(2):171-183.
2. Chuang-Stein C, Stryszak P, Dmitrienko A, Offen W. Challenge of multiple co-primary endpoints: a new approach. Statistics in Medicine 2007; 26:1181-1192.
3. Offen WW, Chuang-Stein C, Dmitrienko A, Littman G, Maca J, Meyerson L, Muirhead R, Stryszak P, Boddy A, Chen K, Copley-Merriman K, Dere W, Givens S, Hall D, Henry D, Jackson J, Krishen A, Liu T, Ryder SW, Sankoh AJ, Wang J, Yeh CH. Multiple co-primary endpoints: medical and statistical solutions. a report from the multiple endpoints expert team of the pharmaceutical research and manufacturers of America. Drug Information Journal 2007; 41:31-46.
4. SAS OnlineDoc. Version 8. Copyright 1999 by SAS Institute Inc., Cary, NC, U.S.A.