Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per μl in Europe and North America: A pooled cohort observational study

The Lancet

Volumn 376, Issue 9738, 2010, Pages 340-345

  Lodwick, Rebecca K ^a,b   Sabin, Caroline A ^a,c,s   Porter, K ^a,s,ay   Ledergerber, B ^a   Van Sighem, Ard ^f   Cozzi Lepri, A ^s   Khaykin, P ^s   Mocroft, Amanda ^h   Jacobson, L P ^i,ai   De Wit, Stephane ^j,s   Obel, N ^s   Castagna, A ^s   Wasmuth, J C ^s   Gill, John ^m,s   Klein, Marina B ^m   Gange, S ^s   Riera, M ^ar   Mussini, C ^s   Gutierrez F ^w   Touloumi, Giota ^q,s,v   Carrieri, Patrizia ^r   Guest, Jodie L ^s   Brockmeyer, N H ^ai   Phillips, Andrew N ^a,u   Antoniadou, A ^v   Gargalianos Kakolyris, P ^v   Katsarou, O ^v   Kordossis, T ^v   Lazanas, M ^v   Panos, G ^v   Paparizos, V ^v   Paraskevis, D ^v   Petrikkos, G ^v   Sambatakou, H ^v   Skoutelis, A ^v   Pantazis, N ^v   Bakoyannis, G ^v   Gioukari, V ^v   de Wolf, F ^s   O Bezemer, D ^s   Gras, L A J ^s   Kesselring, A M ^s   van Sighem, A I ^s   Smit, C ^s   Zhang, S ^s   Zaheri, S ^s   Prins, J M ^s,s   Schreij, G ^s   Bravenboer, B ^s   van der Ende, M E ^s   Kauff mann, R H ^s   ten Kate, R W ^s   Kroon, F P ^s   Bronsveld, W ^s   Vriesendorp, R ^s   van Houte, D ^s   ten Napel, C H H ^s   Brinkman, K ^s   van Eeden, A ^s   Mulder, J W ^s   Juttmann, J R ^s   Veenstra, J ^s   Koopmans, P P ^s   Sprenger, H G ^s   Hoepelman, I M ^s   Danner, S A ^s   Richter, C ^s   Tanis, A A ^s   Van, A ^s   Delforge, M ^s   Necsoi, C ^s   Demeester, R ^s   Gennotte, A F ^s   Gerard, M ^s   Guillaume, M P ^s   Hermans, P ^s   Kabeya, K ^s   Konopnicki, D ^s   Martin, C ^s   Libois, A ^s   Payen, M C ^s   Semaille, P ^s   Van Laethem, Y ^s   Del Amo, J ^s,w   Meyer, L ^s   Bucher, H C ^a,s   Chene G ^s   Pillay, D ^a,s   Rosinska, M ^s   Lodi, S ^s   Coughlin, K ^s   Walker, S ^s   Babiker, A ^a,s   de Luca, A ^s   Fisher, M ^a,s   Muga, R ^s   Fatkenheuer G ^s   Rockstroh, J ^s   Vehreschild, J ^s   Hertenstein, C ^s   Berenguer, J ^w,ab   Garcia F ^w,ah   Labarga, P ^w   Moreno, S ^w,ag   Angeles Munoz M ^w   Caro Murillo, A M ^w   Sobrino, P ^w   Perez Cachafeiro S ^w   Jarrin I ^w   Alejos, B ^w   Garcia I ^w,aw   Gomez Sirvent J ^w   Soriano, V ^x   Pulido, F ^y   Iribarren, J ^z   Masia M ^aa   Vidal, F ^ac   Sanz, J ^ad   Blanco, J A ^ae   Sola, J ^af   Gerstoft, J ^s   Kronborg, G ^s   Roge B ^s   Larsen, C S ^s   Pedersen, G ^s   Laursen, A L ^s   Nielsen, L ^s   Jensen, J ^s   Babacan, E ^s   Bickel, M ^s   Bodtlander A ^s   Brodt, H R ^s   Carlebach, A ^s   Gute, P ^s   Haberl, A ^s,ai   Helm, E ^s   Klauke, S ^s   Knecht, G ^s   Lennemann, T ^s   Locher, L ^s   Lutz, T ^s   Mosch M ^s   Muller A ^s   Nisius, G ^s   Staszewski, S ^s   Stephan, C ^s   Sturmer M ^s   von Hentig, N ^s   Wolf, T ^s   Rimland, D ^s   Moanna, A ^s   Moorfi eld, M ^s   Dorsey, M ^s   Desilva, KE ^s   Schlueter Wirtz, S ^s   Mindley, R ^s   Dozier, R ^s   Robinson, Y ^s   Brown, P ^s   Moroni, M ^s   Angarano, G ^s   Antinori, A ^s   Carosi, G ^s   Cauda, R ^s   d'Arminio Monforte A ^s   Di Perri, G ^s   Galli, M ^s   Ghinelli, F ^s   Iardino, R ^s   Ippolito, G ^s   Lazzarin, A ^s   Mazzotta, F ^s   Perno, CF ^s   Viale, PL ^s   Von Schlosser, F ^s   Ammassari, A ^s   Balotta, C ^s   Bonfanti, P ^s   Capobianchi, MR ^s   Ceccherini Silberstein, F ^s   Gervasoni, C ^s   Girardi, E ^s   Lo Caputo, S ^s   Maggiolo, F ^s   Murri, R ^s   Puoti, M ^s   Torti, C ^s   Salpietro, S ^s   Marangione, M ^s   Galli, L ^s   Gianotti, N ^s   Cossarini, F ^s   Spagnuolo, V ^s   Arendt, G ^ai   Esser, S ^ai   Jager H ^ai   Schwarze, S ^ai   Stoll, M ^ai   Wolf, H ^ai   Jansen, K ^ai   Michalik, C ^ai   SkaletzRorowski, A ^ai   Konigs C ^ai   Gingelmaier, A ^ai   Margolick, J B ^ai   Phair, J P ^aj   Wolinsky, S M ^aj   Detels, R ^ak   Rinaldo, C R ^al   Boirot, C ^s   Bouhnik, A D ^s   Carrieri, M P ^s   Cassuto, J P ^s   Chesney, M ^s   Cohen, J ^s   Dellamonica, P ^s   Dujardin, P ^s   Gallais, H ^s   Gastaut, J A ^s   Kurkdji, P ^s   Lepeu, G ^s   Mechali, D ^s   Moatti, J P ^s   Moreau, J ^s   Negre M ^s   Obadia, Y ^s   Poizot Martin, I ^s   Pradier, C ^s   Preau M ^s   Rey, D ^s   Roux, P ^s   Rouzioux, C ^s   Sobel, A ^s   Spire, B ^s   Tremolieres F ^s   Villes, V ^s   Vincent, E ^s   Vlahov, D ^s   Borghi, V ^s   Casabona, J ^am   Miro J M ^an   Gatell, J M ^ao   Lopez Dieguez Puerta M ^ao   Tural, C ^ap   Clotet, B ^ap   Podzamczer, D ^aq   Ferrer, E ^aq   Murillas, J ^ar   Segura, F ^as   Navarro, G ^as   Force, L ^at   Vilaro J ^au   Masabeu, A ^av   Guadarrama, M ^ax   Betancourt, A J ^s   Romero, A ^s   Agusti C ^s   Battegay, M ^a   Bernasconi, E ^a   Boni J ^a   Burgisser P ^a   Calmy, A ^a   Cavassini, M ^a   Dubs, R ^a   Egger, M ^a   Elzi, L ^a   Fischer, M ^a   Flepp, M ^a   Fontana, A ^a   Francioli, P ^a   Furrer, H ^a   Fux, C A ^a   Gorgievski, M ^a   Gunthard H F ^a   Hirsch, H H ^a   Hirschel, B ^a   Hosli I ^a   Kahlert, C ^a   Kaiser, L ^a   Karrer, U ^a   Kind, C ^a   Klimkait, T ^a   Martinetti, G ^a   Martinez, B ^a   Muller N ^a   Nadal, D ^a   Paccaud, F ^a   Pantaleo, G ^a   Rauch, A ^a   Regenass, S ^a   Rickenbach, M ^a   Rudin, C ^a   Schmid, P ^a   Schultze, D ^a   Schoni F ^a   Schupbach J ^a   Speck, R ^a   Taff e P ^a   Telenti, A ^a   Trkola, A ^a   Vernazza, P ^a   Weber, R ^a   Yerly UK CHIC Steering committee: J Ainsworth, S ^a   Anderson, J ^a   Delpech, V ^a   Dunn, D ^a,ay   Easterbrook, P ^a   Gazzard, B ^a   Gilson, R ^a   Gompels, M ^a   Hill, T ^a   Johnson, M ^a   Leen, C ^a   Nelson, M ^a   Orkin, C ^a   Palfreeman, A ^a   Post, F ^a   Schwenk, A ^a   Walsh, J ^a   Bansi, L ^a   Huntington, S ^a   Glabay, A ^ay   Anastos, K ^s   Minkoff, H ^s   Young, M ^s   Greenblatt, R ^s   Levine, A ^s   Cohen, M ^s   more..

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Analysis and Writing Committee   (United States)

^c UK CHIC   (United Kingdom)

^d CASCADE   (Australia)

^e Swiss HIV   (Switzerland)

^f Cohort Study ^*  (Switzerland)

^g ICONA   (Canada)

^h HIV cohort Frankfurt   (Germany)

ⁱ EuroSIDA Coordinating Centre   (Denmark)

^j MACS   (United States)

^k Danish HIV Cohort Study   (Denmark)

^l IDD HSR   (United States)

^m Southern Alberta Cohort   (Canada)

ⁿ Montreal Chest Immunodefi Ciency Cohort   (Canada)

^o WIHS   (United States)

^p PISCIS   (United States)

^q CoRIS and CoRIS MD ^*  (United States)

^r AMAC   (United States)

^s MANIF 2000 ^*

^t HAVACS   (United States)

^u KOMPNET   (Australia)

^v UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^w HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^x HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^y HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^z HOSPITAL DONOSTIA   (Spain)

^aa HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^ab HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^ac HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^ad HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^ae HOSPITAL SAN PEDRO   (Spain)

^af Universidad Pública de Navarra   (Spain)

^ag HOSPITAL RAMÓN Y CAJAL   (Spain)

^ah HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^ai JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^aj and Cook County Bureau of Health Services ^*  (United States)

^ak UNIVERSITY OF CALIFORNIA   (United States)

^al UNIVERSITY OF PITTSBURGH   (United States)

^am UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^an UNIVERSITY OF BARCELONA   (Spain)

^ao INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^ap HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^aq HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^ar HOSPITAL SON DURETA   (Spain)

^as Servicio de Cirugía General Y Aparato Digestivo   (Spain)

^at HOSPITAL DE MATARÓ   (Spain)

^au Hospital de Vic   (Spain)

^av Hospital de Palamós   (Spain)

^aw Hospital General d'Hospitalet   (Spain)

^ax Hospital Alt Penedès   (Spain)

^ay London Hospital   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CIGARETTE SMOKING; COHORT ANALYSIS; COMORBIDITY; DEATH; EUROPE; FEMALE; FOLLOW UP; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; MORTALITY; NORTH AMERICA; OBSERVATIONAL STUDY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; VIRUS HEPATITIS; VIRUS LOAD;

EID: 77955716641     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)60932-4     Document Type: Article

References (23)

1. AN Phillips, J Elford, C Sabin, M Bofill, G Janossy, CA Lee Immunodeficiency and the risk of death in HIV infection JAMA 268 1992 2662 2666
2. R Weber, CA Sabin, N Friis-Møller Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study Arch Intern Med 166 2006 1632 1641
3. C Smit, R Geskus, S Walker Effective therapy has altered the spectrum of cause-specific mortality following HIV seroconversion AIDS 20 2006 741 749
4. AN Phillips, J Neaton, JD Lundgren The role of HIV in serious diseases other than AIDS AIDS 22 2008 2409 2418
5. N Clumeck, A Pozniak, F Raffi European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of HIV-infected adults HIV Med 9 2008 65 71
6. SM Hammer, JJ Eron, P Reiss Antiretroviral treatment of adult HIV infection - 2008 recommendations of the International AIDS Society USA panel JAMA 300 2008 555 570
7. JAC Sterne, M May, D Costagliola Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies Lancet 373 2009 1352 1363
8. MM Kitahata, SJ Gange, AG Abraham Effect of early versus deferred antiretroviral therapy for HIV on survival N Engl J Med 360 2009 1815 1826
9. S Emery, JA Neuhaus, AN Phillips Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study J Infect Dis 197 2008 1133 1144
10. J Kjaer, B Ledergerber HIV cohort collaborations: proposal for harmonization of data exchange Antivir Ther 9 2004 631 633
11. E Lloyd-Smith, E Brodkin, E Wood Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia AIDS 20 2006 445 450
12. FC Lampe, CJ Smith, S Madge Success of clinical care for human immunodeficiency virus infection according to demographic group among sexually infected patients in a routine clinic population, 1999 to 2004 Arch Intern Med 167 2007 692 700
13. ABE Hansen, J Gerstoft, G Kronborg, C Pedersen, HT Sorensen, N Obel Mortality in siblings of patients coinfected with HIV and hepatitis C virus J Infect Dis 195 2007 230 235
14. A Phillips, P Pezzotti CASCADE Collaboration Short-term risk of AIDS according to current CD4 cell count and viral load in antiretroviral drug-naive individuals and those treated in the monotherapy era AIDS 18 2004 51 58
15. AN Phillips, B Gazzard, R Gilson Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count AIDS 21 2007 1717 1721
16. JD Neaton, B Grund Earlier initiation of antiretroviral therapy in treatment-naive patients: implications of results of treatment interruption trials Curr Opin HIV AIDS 3 2008 112 117
17. B Marin, R Thiebaut, H Bucher Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy AIDS 23 2009 1743 1753
18. 3on long-term combination antiretroviral therapy reach same mortality rates as the general population J Acquir Immune Defic Syndr 46 2007 72 77
19. A van Sighem, S Danner, AC Ghani, L Gras, RM Anderson, F de Wolf Mortality in patients with successful initial response to highly active antiretroviral therapy is still higher than in non-HIV-Infected individuals J Acquir Immune Defic Syndr 40 2005 212 218
20. C Jaggy, J von Overbeck, B Ledergerber Mortality in the Swiss HIV Cohort Study (SHCS) and the Swiss general population Lancet 362 2003 877 878
21. K Bhaskaran, O Hamouda, M Sannes Changes in the risk of death after HIV seroconversion compared with mortality in the general population JAMA 300 2008 51 59
22. CA Sabin, A Schwenk, MA Johnson Late diagnosis in the HAART era: proposed common definitions and associations with mortality AIDS 24 2010 723 727