N-Linked glycoengineering for human therapeutic proteins in bacteria

Biotechnology Letters

Volumn 32, Issue 9, 2010, Pages 1189-1198

  Pandhal, Jagroop ^a   Wright, Phillip C ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Campylobacter jejuni; E. coli; Metabolic engineering; N Linked glycosylation; Therapeutic proteins

Indexed keywords

CAMPYLOBACTER JEJUNI; E. COLI; METABOLIC ENGINEERING; N-LINKED GLYCOSYLATION; THERAPEUTIC PROTEIN;

BACTERIOLOGY; ESCHERICHIA COLI; ESTERIFICATION; GLYCOSYLATION; MACHINERY; METABOLISM; PROTEINS;

BACTERIA;

GLYCOPROTEIN; RECOMBINANT PROTEIN;

BIOTECHNOLOGY; CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI; GENETICS; GLYCOSYLATION; HUMAN; METABOLISM; METHODOLOGY; PROTEIN PROCESSING; REVIEW;

BIOTECHNOLOGY; CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; METABOLIC NETWORKS AND PATHWAYS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI; PROKARYOTA;

EID: 77955713515     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-010-0289-6     Document Type: Review

References (62)

1. Abu-Qarn M, Eichler J, Sharon N (2008) Not just for Eukarya anymore: protein glycosylation in bacteria and Archaea. Curr Opin Struct Biol 18: 544-550.
2. Apweiler R, Hermjakob H, Sharon N (1999) On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim Biophys Acta 1473: 4-8.
3. Baneyx F (1999) Recombinant protein expression in Escherichia coli. Curr Opin Biotechnol 10: 411-421.
4. Bickel T, Lehle L, Schwarz M et al (2005) Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol. J Biol Chem 280: 34500-34506.
5. Burda P, Aebi M (1999) The dolichol pathway of N-linked glycosylation. Biochim Biophys Acta 1426: 239-257.
6. Chantret I, Dancourt J, Barbat A et al (2005) Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae. J Biol Chem 280: 9236-9242.
7. Dempski RE Jr, Imperiali B (2002) Oligosaccharyl transferase: gatekeeper to the secretory pathway. Curr Opin Chem Biol 6: 844-850.
8. Egrie JC, Browne JK (2001) Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer 84(Suppl1): 3-10.
9. Elliott S, Lorenzini T, Asher S et al (2003) Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat Biotechnol 21: 414-421.
10. Fanger MW, Smyth DG (1972) Oligosaccharide units of rabbit IgG multiple CHO attachment sites. Biochem J 127: 757-765.
11. Feldman MF, Wacker M, Hernandez M et al (2005) Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli. Proc Natl Acad Sci USA 102: 3016-3021.
12. Fussenegger M, Schlatter S, Datwyler D et al (1998) Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells. Nat Biotechnol 16: 468-472.
13. Gao XD, Tachikawa H, Sato T et al (2005) Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation. J Biol Chem 280: 36254-36262.
14. Glover KJ, Weerapana E, Chen MM et al (2006) Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuniN-linked glycosylation pathway. Biochemistry 45: 5343-5350.
15. Gomord V, Faye L (2004) Posttranslational modification of therapeutic proteins in plants. Curr Opin Plant Biol 7: 171-181.
16. Guerry P, Ewing C, Schirm M et al (2006) Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence. Mol Microbiol 60: 299-311.
17. Hamilton SR, Gerngross TU (2007) Glycosylation engineering in yeast: the advent of fully humanized yeast. Curr Opin Biotechnol 18: 387-392.
18. Hamilton SR, Bobrowicz P, Bobrowicz B et al (2003) Production of complex human glycoproteins in yeast. Science 301: 1244-1246.
19. Hitchen PG, Dell A (2006) Bacterial glycoproteomics. Microbiology 152: 1575-1580.
20. Houdebine LM (2002) Antibody manufacture in transgenic animals and comparisons with other systems. Curr Opin Biotechnol 13: 625-629.
21. Inga B, Schmidt MA (2002) Never say never again: protein glycosylation in pathogenic bacteria. Mol Microbiol 45: 267-276.
22. Jacobs PP, Callewaert N (2009) N-glycosylation engineering of biopharmaceutical expression systems. Curr Mol Med 9: 774-800.
23. Johnson IS (1983) Human insulin from recombinant DNA technology. Science 219: 632-637.
24. Kelleher DJ, Gilmore R (2006) An evolving view of the eukaryotic oligosaccharyltransferase. Glycobiology 16: 47R-62R.
25. Kelly J, Jarrell H, Millar L et al (2006) Biosynthesis of the N-linked glycan in Campylobacter jejuni and addition onto protein through block transfer. J Bacteriol 188: 2427-2434.
26. Kowarik M, Numao S, Feldman MF et al (2006) N-linked glycosylation of folded proteins by the bacterial oligosaccharyltransferase. Science 314: 1148-1150.
27. Legardinier S, Klett D, Poirier J-C et al (2005) Mammalian-like nonsialyl complex-type N-glycosylation of equine gonadotropins in Mimic™ insect cells. Glycobiology 15: 776-790.
28. Lehle L, Tanner W (1978) Glycosyl transfer from dolichyl phosphate sugars to endogenous and exogenous glycoprotein acceptors in yeast. Eur J Biochem 83: 563-570.
29. Li H, Sethuraman N, Stadheim TA et al (2006) Optimization of humanized IgGs in glycoengineered Pichia pastoris. Nat Biotechnol 24: 210-215.
30. Linton D, Allan E, Karlyshev AV et al (2002) Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Mol Microbiol 43: 497-508.
31. Linton D, Dorrell N, Hitchen PG et al (2005) Functional analysis of the Campylobacter jejuniN-linked protein glycosylation pathway. Mol Microbiol 55: 1695-1703.
32. Mescher MF, Strominger JL, Watson SW (1974) Protein and carbohydrate composition of the cell envelope of Halobacterium salinarium. J Bacteriol 120: 945-954.
33. Messner P (2004) Prokaryotic glycoproteins: unexplored but important. J Bacteriol 186: 2517-2519.
34. Mobili P, Serradell Mde L, Trejo S et al (2009) Heterogeneity of S-layer proteins from aggregating and non-aggregating Lactobacillus kefir strains. Antonie van Leeuwenhoek 95: 363-372.
35. Müller D, Bayer K, Mattanovich D (2006) Potentials and limitations of prokaryotic and eukaryotic expression systems for recombinant protein production-a comparative view. In: The 4th recombinant protein production meeting. Microbial Cell Factories, Barcelona, Spain.
36. Parkhill J, Wren BW, Mungall K et al (2000) The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403: 665-668.
37. Peng Z, Wu H, Ruiz T et al (2008) Role of gap3 in Fap1 glycosylation, stability, in vitro adhesion, and fimbrial and biofilm formation of Streptococcus parasanguinis. Oral Microbiol Immunol 23: 70-78.
38. Potgieter TI, Cukan M, Drummond JE et al (2009) Production of monoclonal antibodies by glycoengineered Pichia pastoris. J Biotechnol 139: 318-325.
39. Price NP, Momany FA (2005) Modeling bacterial UDP-HexNAc: polyprenol-P HexNAc-1-P transferases. Glycobiology 15: 29R-42R.
40. Rangarajan ES, Bhatia S, Watson DC et al (2007) Structural context for protein N-glycosylation in bacteria: the structure of PEB3, an adhesin from Campylobacter jejuni. Protein Sci 16: 990-995.
41. Sarkar A, Fritz T, Taylor W et al (1995) Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1→4GlcNAc beta-O-naphthalenemethanol. Proc Natl Acad Sci USA 92: 3323-3327.
42. Schaffer C, Messner P (2004) Surface-layer glycoproteins: an example for the diversity of bacterial glycosylation with promising impacts on nanobiotechnology. Glycobiology 14: 31R-42R.
43. Schwarz F, Huang W, Li C et al (2010) A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation. Nat Chem Biol 6(4): 264-266.
44. Sethuraman N, Stadheim TA (2006) Challenges in therapeutic glycoprotein production. Curr Opin Biotechnol 17: 341-346.
45. Shao J, Zhang J, Kowal P et al (2002) Donor substrate regeneration for efficient synthesis of globotetraose and isoglobotetraose. Appl Environ Microbiol 68: 5634-5640.
46. Sheeley DM, Merrill BM, Taylor LC (1997) Characterization of monoclonal antibody glycosylation: comparison of expression systems and identification of terminal alpha-linked galactose. Anal Biochem 247: 102-110.
47. Skretas G, Carroll S, DeFrees S et al (2009) Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli. Microb Cell Fact 8: 50.
48. Strasser R, Altmann F, Mach L et al (2004) Generation of Arabidopsis thaliana plants with complex N-glycans lacking beta1, 2-linked xylose and core alpha1, 3-linked fucose. FEBS Lett 561: 132-136.
49. Szymanski CM, Burr DH, Guerry P (2002) Campylobacter protein glycosylation affects host cell interactions. Infect Immun 70: 2242-2244.
50. Tatar LD, Marolda CL, Polischuk AN et al (2007) An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling. Microbiology 153: 2518-2529.
51. van Berkel PH, Welling MM, Geerts M et al (2002) Large scale production of recombinant human lactoferrin in the milk of transgenic cows. Nat Biotechnol 20: 484-487.
52. Varki A (1993) Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 3: 97-130.
53. Varki A, Cummings R, Esko J et al (1999) Essentials of glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
54. Wacker M, Linton D, Hitchen PG et al (2002) N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298: 1790-1793.
55. Wang L, Brock A, Herberich B et al (2001) Expanding the genetic code of Escherichia coli. Science 292: 498-500.
56. Warner TG (1999) Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting. Glycobiology 9: 841-850.
57. Weerapana E, Imperiali B (2006) Asparagine-linked protein glycosylation: from eukaryotic to prokaryotic systems. Glycobiology 16: 91R-101R.
58. Young NM, Brisson JR, Kelly J et al (2002) Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni. J Biol Chem 277: 42530-42539.
59. Yuen CT, Storring P, Tiplady R et al (2005) Relationships between the N-glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures. Adv Exp Med Biol 564: 141-142.
60. Yurist-Doutsch S, Chaban B, VanDyke DJ et al (2008) Sweet to the extreme: protein glycosylation in Archaea. Mol Microbiol 68: 1079-1084.
61. Zhang Z, Gildersleeve J, Yang YY et al (2004) A new strategy for the synthesis of glycoproteins. Science 303: 371-373.
62. Zhang Z, Gildersleeve J, Yang YY et al (2009) Retraction. Science 326: 1187.