The Impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Converse, Paul J ^a   Eisenach, Kathleen D ^b   Theus, Sue A ^b   Nuermberger, Eric L ^a   Tyagi, Sandeep ^a   Ly, Lan H ^c   Geiman, Deborah E ^a   Guo, Haidan ^a   Nolan, Scott T ^a   Akar, Nicole C ^a   Klinkenberg, Lee G ^a   Gupta, Radhika ^a   Lun, Shichun ^a   Karakousis, Petros C ^a   Lamichhane, Gyanu ^a   McMurray, David N ^c   Grosset, Jacques H ^a   Bishai, William R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONGO RED; LIPID; PHTHIOCEROL DIMYCOCEROSATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; DELETION MUTANT; GENETIC MANIPULATION; GUINEA PIG; LUNG TUBERCULOSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; THIN LAYER CHROMATOGRAPHY; AEROSOL; ANIMAL; CYTOLOGY; GENE DELETION; GENETICS; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PATHOGENICITY; REPRODUCTIVE FITNESS; STANDARD; TUBERCULOSIS; VIRULENCE; VIRUS CULTURE;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA; MUS; MYCOBACTERIUM TUBERCULOSIS;

AEROSOLS; ANIMALS; BACTERIOLOGICAL TECHNIQUES; GENETIC FITNESS; GUINEA PIGS; LIPIDS; MICE; MODELS, ANIMAL; MYCOBACTERIUM TUBERCULOSIS; RESEARCH DESIGN; SEQUENCE DELETION; SERIAL PASSAGE; TUBERCULOSIS; VIRULENCE;

EID: 77955708912     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010289     Document Type: Article

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