Diagnostic techniques and procedures for establishing the microbial etiology of ventilatorassociated pneumonia for clinical trials: The Pros for quantitative cultures

Clinical Infectious Diseases

Volumn 51, Issue SUPPL. 1, 2010, Pages

  Chastre, Jean ^a   Trouillet, Jean Louis ^a   Combes, Alain ^a   Luyt, Charles Edouard ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; BACTERIAL PNEUMONIA; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BRONCHOGRAPHY; BRONCHUS SECRETION; CLINICAL ASSESSMENT; CLINICAL TRIAL; COLONY FORMING UNIT; COMPARATIVE STUDY; CONFERENCE PAPER; DIAGNOSTIC PROCEDURE; DRUG EFFICACY; FIBEROPTIC BRONCHOSCOPY; FOLLOW UP; HUMAN; LUNG EDEMA; LUNG INFILTRATE; PHARMACODYNAMICS; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; SENSITIVITY AND SPECIFICITY; SURVIVAL; SYMPTOMATOLOGY; TRACHEAL ASPIRATION PROCEDURE; VENTILATOR ASSOCIATED PNEUMONIA; BACTERIA; CLASSIFICATION; CROSS INFECTION; DRUG MONITORING; ISOLATION AND PURIFICATION; LUNG LAVAGE; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PROCEDURES;

BACTERIA; BACTERIOLOGICAL TECHNIQUES; BRONCHOALVEOLAR LAVAGE FLUID; CROSS INFECTION; DRUG MONITORING; HUMANS; PNEUMONIA, BACTERIAL; PNEUMONIA, VENTILATOR-ASSOCIATED; SENSITIVITY AND SPECIFICITY;

EID: 77955689254     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/653054     Document Type: Conference Paper

References (45)

1. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002; 165:867-903.
2. Bonten MJ, Bergmans DC, Stobberingh EE, et al. Implementation of bronchoscopic techniques in the diagnosis of ventilator-associated pneumonia to reduce antibiotic use. Am J Respir Crit Care Med 1997; 156:1820-1824.
3. Fagon JY, Chastre J, Wolff M, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial. Ann Intern Med 2000; 132:621-630.
4. Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 2003; 290:2588-2598.
5. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388-416.
6. Fagon J, Patrick H, Haas DW, et al. Treatment of gram-positive nos-ocomial pneumonia. Prospective randomized comparison of quinu-pristin/ dalfopristin versus vancomycin. Am J Respir Crit Care Med 2000; 161:753-762.
7. Chastre J, Wunderink R, Prokocimer P, Lee M, Kaniga K, Friedland I. Efficacy and safety of intravenous infusion of doripenem versus imi-penem in ventilator-associated pneumonia: a multicenter, randomized study. Crit Care Med 2008; 36:1089-1096.
8. A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 2006; 355:2619-2630.
9. Wunderink RG, Woldenberg LS, Zeiss J, Day CM, Ciemins J, Lacher DA. The radiologic diagnosis of autopsy-proven ventilator-associated pneumonia. Chest 1992; 101:458-463.
10. Johanson WG, Pierce AK, Sanford JP, Thomas GD. Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med 1972; 77:701-706.
11. Baselski V. Microbiologic diagnosis of ventilator-associated pneumonia. Infect Dis Clin North Am 1993; 7:331-357.
12. Hill JD, Ratliff JL, Parrott JC, et al. Pulmonary pathology in acute respiratory insufficiency: lung biopsy as a diagnostic tool. J Thorac Cardiovasc Surg 1976; 71:64-71.
13. Kirtland SH, Corley DE, Winterbauer RH, et al. The diagnosis of ventilator-associated pneumonia: a comparison of histologic, micro-biologic, and clinical criteria. Chest 1997; 112:445-457.
14. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lav-age fluid. Am Rev Respir Dis 1991; 143:1121-1129.
15. Schurink CA, Van Nieuwenhoven CA, Jacobs JA, et al. Clinical pulmonary infection score for ventilator-associated pneumonia: accuracy and inter-observer variability. Intensive Care Med 2004; 30:217-224.
16. Klompas M. Does this patient have ventilator-associated pneumonia? JAMA 2007; 297:1583-1593.
17. Luyt CE, Chastre J, Fagon JY. Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumonia. Intensive Care Med 2004; 30:844-852.
18. Combes A, Luyt CE, Fagon JY, Wolff M, Trouillet JL, Chastre J. Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia. Crit Care Med 2007; 35:146-154.
19. Fartoukh M, Maitre B, Honore S, Cerf C, Zahar JR, Brun-Buisson C. Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited. Am J Respir Crit Care Med 2003; 168:173-179.
20. Luna CM, Blanzaco D, Niederman MS, et al. Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med 2003; 31:676-682.
21. de Jaeger A, Litalien C, Lacroix J, Guertin MC, Infante-Rivard C. Protected specimen brush or bronchoalveolar lavage to diagnose bacterial nosocomial pneumonia in ventilated adults: a meta-analysis. Crit Care Med 1999; 27:2548-2560.
22. Baughman RP. Protected-specimen brush technique in the diagnosis of ventilator-associated pneumonia. Chest 2000; 117(4 Suppl 2): 203S-206S.
23. Torres A, El-Ebiary M. Bronchoscopic BAL in the diagnosis of ventilator-associated pneumonia. Chest 2000; 117(4 Suppl 2):198S-202S.
24. Torres A, Martos A, Puig de la Bellacasa J, et al. Specificity of endo-tracheal aspiration, protected specimen brush, and bronchoalveolar lavage in mechanically ventilated patients. Am Rev Respir Dis 1993; 147:952-957.
25. Johanson WG Jr, Seidenfeld JJ, Gomez P, de los Santos R, Coalson JJ. Bacteriologic diagnosis of nosocomial pneumonia following prolonged mechanical ventilation. Am Rev Respir Dis 1988; 137:259-264.
26. Chastre J, Fagon JY, Bornet-Lecso M, et al. Evaluation of bronchoscopic techniques for the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 1995; 152:231-240.
27. Croce MA, Fabian TC, Waddle-Smith L, et al. Utility of Gram's stain and efficacy of quantitative cultures for posttraumatic pneumonia: a prospective study. Ann Surg 1998; 227(5):743-751.
28. Chastre J, Fagon JY, Soler P, et al. Diagnosis of nosocomial bacterial pneumonia in intubated patients undergoing ventilation: comparison of the usefulness of bronchoalveolar lavage and the protected specimen brush. Am J Med 1988; 85:499-506; erratum: Am J Med 1989; 86:258.
29. Veber B, Souweine B, Gachot B, et al. Comparison of direct examination of three types of bronchoscopy specimens used to diagnose nosocomial pneumonia. Crit Care Med 2000; 28:962-968.
30. Timsit JF, Cheval C, Gachot B, et al. Usefulness of a strategy based on bronchoscopy with direct examination of bronchoalveolar lavage fluid in the initial antibiotic therapy of suspected ventilator-associated pneumonia. Intensive Care Med 2001; 27:640-647.
31. Swanson JM, Wood GC, Croce MA, Mueller EW, Boucher BA, Fabian TC. Utility of preliminary bronchoalveolar lavage results in suspected ventilator- associated pneumonia. J Trauma 2008; 65:1271-1277.
32. Forrest A, Nix DE, Ballow CH, Goss TF, Birmingham MC, Schentag JJ. Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 1993; 37:1073-1081.
33. Schentag JJ. Pharmacokinetic and pharmacodynamic surrogate markers: studies with fluoroquinolones in patients. Am J Health Syst Pharm 1999; 56(22 Suppl 3):S21-S24.
34. Marquette CH, Wallet F, Copin MC, et al. Relationship between mi-crobiologic and histologic features in bacterial pneumonia. Am J Respir Crit Care Med 1996; 154:1784-1787.
35. Torres A, Fabregas N, Ewig S, de la Bellacasa JP, Bauer TT, Ramirez J. Sampling methods for ventilator-associated pneumonia: validation using different histologic and microbiological references. Crit Care Med 2000; 28:2799-2804.
36. Rouby JJ. Histology and microbiology of ventilator-associated pneumonias. Semin Respir Infect 1996; 11:54-61.
37. Torres A, el-Ebiary M, Padro L, et al. Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med 1994; 149:324-331.
38. Souweine B, Veber B, Bedos JP, et al. Diagnostic accuracy of protected specimen brush and bronchoalveolar lavage in nosocomial pneumonia: impact of previous antimicrobial treatments. Crit Care Med 1998; 26: 236-244.
39. Montravers P, Fagon JY, Chastre J, et al. Follow-up protected specimen brushes to assess treatment in nosocomial pneumonia. Am Rev Respir Dis 1993; 147:38-44.
40. Prats E, Dorca J, Pujol M, et al. Effects of antibiotics on protected specimen brush sampling in ventilator-associated pneumonia. Eur Res-pir J 2002; 19:944-951.
41. Marquette CH, Herengt F, Mathieu D, Saulnier F, Courcol R, Ramon P. Diagnosis of pneumonia in mechanically ventilated patients: repeatability of the protected specimen brush. Am Rev Respir Dis 1993; 147:211-214.
42. Timsit JF, Misset B, Francoual S, Goldstein FW, Vaury P, Carlet J. Is protected specimen brush a reproducible method to diagnose ICU-acquired pneumonia? Chest 1993; 104:104-108.
43. Gerbeaux P, Ledoray V, Boussuges A, Molenat F, Jean P, Sainty JM. Diagnosis of nosocomial pneumonia in mechanically ventilated patients: repeatability of the bronchoalveolar lavage. Am J Respir Crit Care Med 1998; 157:76-80.
44. Baughman RP. Nonbronchoscopic evaluation of ventilator-associated pneumonia. Semin Respir Infect 2003; 18:95-102.
45. Jourdain B, Novara A, Joly-Guillou ML, et al. Role of quantitative cultures of endotracheal aspirates in the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 1995; 152:241-246.