Pregnancy complicated by diabetes: What is the best level of HbA1c for conception?

Acta Diabetologica

Volumn 47, Issue 3, 2010, Pages 187-192

  Lapolla, Annunziata ^a   Dalfrà, Maria Grazia ^a   Fedele, Domenico ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Congenital malformations; Diabetes; HbA1c; Pregnancy

Indexed keywords

HEMOGLOBIN A1C; INSULIN; INSULIN DERIVATIVE;

BLOOD GLUCOSE MONITORING; CONCEPTION; CONGENITAL MALFORMATION; DISEASE SEVERITY; DRUG MEGADOSE; FETUS MALFORMATION; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MATERNAL DIABETES MELLITUS; METABOLIC REGULATION; NEWBORN DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL VALUE; PATIENT MONITORING; PERINATAL MORTALITY; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; SPONTANEOUS ABORTION; STANDARDIZATION;

DIABETES MELLITUS; FEMALE; FERTILIZATION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; MODELS, BIOLOGICAL; PREGNANCY; PREGNANCY IN DIABETICS; PREGNANCY OUTCOME;

EID: 77955654409     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-010-0199-z     Document Type: Review

References (37)

1. Diabetes care and research in Europe: the Saint Vincent Declaration (1990) Diabet Med 7:360
2. EA Reece CJ Homko 2000 Why do diabetic women deliver malformed infants? Clin Obstet Gynecol 43 1 32 45 10.1097/00003081-200003000-00004 1:STN:280:DC%2BD3c7lvFejuw%3D%3D 10694986 (Pubitemid 30414146)
3. A Lapolla MG Dalfrà G DiCianni M Bonomo E Parretti G Mello 2008 A multicenter Italian study on pregnancy outcome in women with diabetes Nutr Metab Cardiovasc Dis 18 4 291 297 10.1016/j.numecd.2006.12.001 17433638 (Pubitemid 351707608)
4. JL Mills L Baker AS Goldman 1979 Malformations in infants of diabetic mothers occur before the seventh gestational week Implications for treatment Diabetes 28 4 292 293 10.2337/diabetes.28.4.292 1:STN:280:DyaE1M7ntVCnsg%3D%3D 437367
5. IG Ray OTE Brien WS Chan 2001 Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis Q J Med 94 435 444 1:STN:280:DC%2BD3Mvos1Oqsg%3D%3D
6. Reece EA, Eriksson UJ (2004) Congenital malformations: epidemiology, pathogenesis and experimental methods of induction and prevention. Diabetes in women: adolescence, pregnancy and menopause, 3rd edn. Lippincott Williams and Wilkins Philadelphia, Philadelphia, pp 169-204
7. EV Holing CS Beyer ZA Brown FA Connell 1998 Why don't women with diabetes plan their pregnancies? Diabetes Care 21 6 889 895 10.2337/diacare.21.6.889 1:STN:280:DyaK1c3ns1OrtQ%3D%3D 9614603 (Pubitemid 28488777)
8. NK Janz WH Herman MP Becker 1995 Diabetes and pregnancy: factors associated with seeking preconception care Diabetes Care 18 157 165 10.2337/diacare.18.2.157 1:STN:280:DyaK2M3ks1Grtw%3D%3D 7729291
9. JL Kitzmiller JM Block FM Brown, et al. 2008 Managing pre-existing diabetes for pregnancy: summary of evidence and consensus recommendations for care Diabetes Care 31 5 1060 1079 10.2337/dc08-9020 1:CAS:528: DC%2BD1cXmsFGrtbg%3D 18445730
10. Diabetes in pregnancy, management of diabetes and its complications from preconception to the postnatal period. National Collaborating Centre for Women's and Children's Health. March 2008
11. Global Guidelines for Diabetes in Pregnancy (2009) International Diabetes Federation
12. NW Cheung JJ Conn MC d'Emden, et al. 2009 Position statement of the Australian diabetes society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus Med J Aust 191 6 339 344 19769558
13. K Ylinen P Aula UH Stenman T Kesäniemi-Kuokkanen K Teramo 1984 Risk of minor and major fetal malformations in diabetics with high haemoglobin A1c values in early pregnancy Br Med J 289 6441 345 346 10.1136/bmj.289.6441.345 1:STN:280:DyaL2c3otFGluw%3D%3D
14. D Towner SL Kjos B Leung, et al. 1995 Congenital malformations in pregnancies complicated by NIDDM Diabetes Care 18 11 1446 1451 10.2337/diacare.18.11.1446 1:STN:280:DyaK28zlt1CjsQ%3D%3D 8722068
15. A Lapolla MG Dalfrà D Fedele 2008 Pregnancy complicated by type 2 diabetes: an emerging problem Diabetes Res Clin Pract 80 1 2 7 10.1016/j.diabres.2007.11.009 1:CAS:528:DC%2BD1cXktVKhu7g%3D 18201793
16. Pregnancy outcomes in the Diabetes Control, Complication Trial 1996 The diabetes control and complication trial research group Am J Obstet Gynecol 174 1343 1353 10.1016/S0002-9378(96)70683-X (Pubitemid 26131159)
17. L Suhonen V Hiilesmaa K Teramo 2000 Glycaemic control during early pregnancy and fetal malformations in women with type I diabetes mellitus Diabetologia 43 1 79 82 10.1007/s001250050010 1:STN:280:DC%2BD3c7js1erug%3D%3D 10663219
18. GL Nielsen M Møller HAT Sørensen 2006 HbA1c in early diabetic pregnancy and pregnancy outcomes: a Danish population-based cohort study of 573 pregnancies in women with type 1 diabetes Diabetes Care 29 12 2612 2616 10.2337/dc06-0914 17130193 (Pubitemid 44912187)
19. DM Jensen L Korsholm P Ovesen, et al. 2009 Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes Diabetes Care 32 6 1046 1048 10.2337/dc08-2061 19265024
20. A Guerin R Nisenbaum JG Ray 2007 Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with pre-pregnancy diabetes Diabetes Care 30 7 1920 1925 10.2337/dc07-0278 1:CAS:528:DC%2BD2sXotlWht7c%3D 17446531 (Pubitemid 47036383)
21. ME Inkster TP Fahey PT Donnan GP Leese GJ Mires DJ Murphy 2006 Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus: systematic review of observational studies BMC Pregnancy Childbirth 30 6 30 10.1186/1471-2393-6-30 (Pubitemid 44734295)
22. The Diabetes Control and Complications Trial Research Group 1993 The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus N Engl J Med 329 977 986 10.1056/NEJM199309303291401 (Pubitemid 23307905)
23. BM Rosenn M Miodovnik G Holcberg JC Khoury TA Siddiqi 1995 Hypoglycemia: the price of intensive insulin therapy for pregnant women with insulin-dependent diabetes mellitus Obstet Gynecol 85 3 417 422 10.1016/0029-7844(94)00415-A 1:STN:280:DyaK2M7ms1Cqsg%3D%3D 7862383
24. Lapolla A, Dalfrà MG, Lencioni C, Di Cianni G (2008) Hypoglycemia in diabetic pregnancy. In: Hod M, Jovanovic L, DiRenzo GC, deLeiva A, Langer O (eds) Textbook of diabetes and pregnancy, vol 32. Informa Healthcare, UK, p 246
25. IM Evers EW ter Braak HW de Valk B der Schoot N Janssen GHA Visser 2002 Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy Diabetes Care 25 3 554 559 10.2337/diacare.25.3.554 11874946 (Pubitemid 41103352)
26. LR Nielsen U Pedersen-Bjergaard B Thorsteinsson M Johansen P Damm ER Mathiesen 2008 Hypoglycemia in pregnant women with type 1 diabetes: predictors and role of metabolic control Diabetes Care 31 1 9 14 10.2337/dc07-1066 17909091
27. A Kerssen HW de Valk GH Visser 2006 Do HbA1c levels and the self-monitoring of blood glucose levels adequately reflect glycaemic control during pregnancy in women with type 1 diabetes mellitus? Diabetologia 49 1 25 28 10.1007/s00125-005-0057-7 1:CAS:528:DC%2BD28XovFymsw%3D%3D 16341689 (Pubitemid 43151609)
28. A Kerssen HW de Valk GH Visser 2006 Forty-eight-hour first-trimester glucose profiles in women with type 1 diabetes mellitus: a report of three cases of congenital malformation Prenat Diagn 26 2 123 127 10.1002/pd.1340 16463292 (Pubitemid 43287094)
29. A Mosca R Paleari MG Dalfrà, et al. 2006 Reference intervals for haemoglobin A1c in pregnant women: data from an Italian Multicentric study Clin Chem 52 1138 1143 10.1373/clinchem.2005.064899 1:CAS:528:DC%2BD28XltlSrur8%3D 16601066 (Pubitemid 43794427)
30. LR Nielsen P Ekbom P Damm, et al. 2004 HbA1c levels are significantly lower in early and late pregnancy Diabetes Care 27 5 1200 1201 10.2337/diacare.27.5.1200 1:CAS:528:DC%2BD2cXks1Snsr0%3D 15111545 (Pubitemid 38579790)
31. JO Jeppsson U Kolbold J Barr, et al. 2002 Approved IFCC reference method for the measurement of HbA1c in human blood Clin Chem Lab Med 40 78 89 10.1515/CCLM.2002.016 1:CAS:528:DC%2BD38Xis1OgtLg%3D 11916276 (Pubitemid 34196455)
32. G Larciprete H Valensise B Vasapollo, et al. 2003 Maternal body composition at term gestation and birth weight: is there a link? Acta Diabetol 40 S222 S224 10.1007/s00592-003-0071-5 14618478 (Pubitemid 37322760)
33. H Valensise G Larciprete D Arduini D De Lorenzo 2003 The fetal body compartments and their detection during pregnancy Acta Diabetol 40 S79 S82 10.1007/s00592-003-0033-y 14618440 (Pubitemid 37322724)
34. A Lapolla MG Dalfrà MD M Masin, et al. 2003 Analysis of outcome of pregnancy in type 1 diabetics treated with insulin pump or conventional therapy Acta Diabetol 40 143 149 10.1007/s00592-003-0103-1 1:CAS:528: DC%2BD3sXos1Oku7g%3D 14605971 (Pubitemid 37288124)
35. M Gimenez T Conget J Nicolau A Pericot I Levy 2007 Outcome of pregnancy in women with type 1 diabetes intensively treated with continuous subcutaneous insulin infusion or conventional therapy. A case control study Acta Diabetol 44 34 37 10.1007/s00592-007-0239-5 1:STN:280:DC%2BD2s7lvVWksQ%3D%3D 17357884 (Pubitemid 46426961)
36. A Lapolla MG Dafrà R Spezia, et al. 2008 Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience Acta Diabetol 45 1 61 66 10.1007/s00592-008-0024-0 1:CAS:528:DC%2BD1cXhs1yltbc%3D 18227964
37. E Torlone G Di Cianni D Mannino A Lapolla 2009 Insulin analogs and pregnancy: an update Acta Diabetol 46 3 163 172 10.1007/s00592-009-0130-7 1:CAS:528:DC%2BD1MXptVGmsrc%3D 19572099