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Volumn 5, Issue 4, 2010, Pages 407-413

Belimumab for the treatment of systemic lupus erythematosus

Author keywords

B cell; B lymphocyte stimulator; belimumab; Benlysta ; lupus; systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; B CELL ACTIVATING FACTOR; BELIMUMAB; BENLYSTA; CD20 ANTIGEN; CD27 ANTIGEN; CD69 ANTIGEN; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; PLACEBO; PREDNISONE; RIBONUCLEOPROTEIN ANTIBODY; SM ANTIBODY; SYNDECAN 1; UNCLASSIFIED DRUG;

EID: 77955647231     PISSN: 17584272     EISSN: None     Source Type: Journal    
DOI: 10.2217/ijr.10.32     Document Type: Review
Times cited : (4)

References (23)
  • 1
    • 0032769336 scopus 로고    scopus 로고
    • The central and multiple roles of B cells in lupus pathogenesis
    • Chan OT, Madaio MP, Shlomchik MJ: The central and multiple roles of B cells in lupus pathogenesis. Immunol. Rev. 169, 107-121 (1999).
    • (1999) Immunol. Rev. , vol.169 , pp. 107-121
    • Chan, O.T.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 2
    • 0035175146 scopus 로고    scopus 로고
    • Synthesis and release of B-lymphocyte stimulator from myeloid cells
    • Nardelli B, Belvedere O, Roschke V et al.: Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97, 198-204 (2001).
    • (2001) Blood , vol.97 , pp. 198-204
    • Nardelli, B.1    Belvedere, O.2    Roschke, V.3
  • 3
    • 33751095383 scopus 로고    scopus 로고
    • B cell targeted therapy for SLE
    • Sabahi R, Anolik JH: B cell targeted therapy for SLE. Drugs 66(15), 1933-1948 (2006).
    • (2006) Drugs , vol.66 , Issue.15 , pp. 1933-1948
    • Sabahi, R.1    Anolik, J.H.2
  • 4
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan OT, Hannum LG, Haberman AM, Madaio MP, Shlomchik MJ: A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189, 1639-1648 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 5
    • 0020062593 scopus 로고
    • Defective regulation of B lymphocyte colony formation in patients with SLE
    • Kumagai S, Sredni B, House S, Steinberg A, Green I: Defective regulation of B lymphocyte colony formation in patients with SLE. J. Immunol. 228, 258-262 (1982).
    • (1982) J. Immunol. , vol.228 , pp. 258-262
    • Kumagai, S.1    Sredni, B.2    House, S.3    Steinberg, A.4    Green, I.5
  • 7
    • 0942268734 scopus 로고    scopus 로고
    • Peripheral B cell maturation: The intersection of selection and homeostasis
    • Cancro MP: Peripheral B cell maturation: the intersection of selection and homeostasis. Immunol. Rev. 197, 89-101 (2004).
    • (2004) Immunol. Rev. , vol.197 , pp. 89-101
    • Cancro, M.P.1
  • 8
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: Member of the TNF family and B lymphocyte stimulator
    • Moore PA, Belvedere O, Orr A et al.: BLyS: member of the TNF family and B lymphocyte stimulator. Science 285, 260-263 (1999).
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3
  • 9
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay F, Woodcock SA, Lawton P et al.: Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190, 1697-1710 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1697-1710
    • MacKay, F.1    Woodcock, S.A.2    Lawton, P.3
  • 10
    • 70350520105 scopus 로고    scopus 로고
    • B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: Disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
    • Collins CE, Gavin AL, Migone T-S, Hilbert DM, Nemazee D, Stohl W: B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels Arthritis Res. Ther. 8, R6 (2006).
    • (2006) Arthritis Res Ther. , vol.8
    • Collins, C.E.1    Gavin, A.L.2    Migone, T.-S.3    Hilbert, D.M.4    Nemazee, D.5    Stohl, W.6
  • 11
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in SLE
    • Petri M, Stohl W, Chatham W et al.: Association of plasma B lymphocyte stimulator levels and disease activity in SLE. Arthritis Rheum. 58, 2453-2459 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 2453-2459
    • Petri, M.1    Stohl, W.2    Chatham, W.3
  • 12
    • 0242495115 scopus 로고    scopus 로고
    • Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator
    • Baker KP, Edwards B, Main SH et al.: Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis Rheum. 48, 3253-3265 (2003).
    • (2003) Arthritis Rheum. , vol.48 , pp. 3253-3265
    • Baker, K.P.1    Edwards, B.2    Main, S.H.3
  • 13
    • 0346026830 scopus 로고    scopus 로고
    • Safety, pharmacokinetic and pharmacodynamic results of a Phase i single and double dose-escalation study of Lymphostat-B in SLE patients
    • Furie R, Stohl W, Ginzler EM et al.: Safety, pharmacokinetic and pharmacodynamic results of a Phase I single and double dose-escalation study of Lymphostat-B in SLE patients. Arthritis Rheum. 48(9), S377 (2003).
    • (2003) Arthritis Rheum. , vol.48 , Issue.9
    • Furie, R.1    Stohl, W.2    Ginzler, E.M.3
  • 14
    • 33845914447 scopus 로고    scopus 로고
    • Belimumab, a fully human monoclonal antibody to BlyS, shows bioactivity and reduces systemic lupus erythematosus disease activity
    • Wallace DJ, Lisse J, Stohl W et al.: Belimumab, a fully human monoclonal antibody to BlyS, shows bioactivity and reduces systemic lupus erythematosus disease activity. Ann. Rheum. Dis. 65, 62 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 62
    • Wallace, D.J.1    Lisse, J.2    Stohl, W.3
  • 15
    • 33845913894 scopus 로고    scopus 로고
    • Multiple SLE disease activitiy measures in a multi-center Phase II SLE trial demonstrate belimumab improves or stabilizes SLE activity
    • Furie R, Lisse J, Merill JT et al.: Multiple SLE disease activitiy measures in a multi-center Phase II SLE trial demonstrate belimumab improves or stabilizes SLE activity. Ann. Rheum. Dis. 65, 63 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 63
    • Furie, R.1    Lisse, J.2    Merill, J.T.3
  • 16
    • 44449114932 scopus 로고    scopus 로고
    • Novel combined response endpoint shows that belimumab improves or stabilizes SLE disease activity in a Phase II trial
    • Furie R, Wallace D, Lisse J et al.: Novel combined response endpoint shows that belimumab improves or stabilizes SLE disease activity in a Phase II trial. Lupus 16, 43 (2007).
    • (2007) Lupus , vol.16 , pp. 43
    • Furie, R.1    Wallace, D.2    Lisse, J.3
  • 18
    • 77955644616 scopus 로고    scopus 로고
    • LBSL02 study group. Changes in circulating B-cell subtype counts autoantibody levels and immunoglobulin that associate with therapeutic responsiveness in SLE to BLyS protein antagonism by belimumab
    • Abstract
    • Chatham W, Stohl W, Merrill JT et al.: LBSL02 study group. Changes in circulating B-cell subtype counts, autoantibody levels and immunoglobulin that associate with therapeutic responsiveness in SLE to BLyS protein antagonism by belimumab. EULAR (2007) (Abstract).
    • (2007) EULAR
    • Chatham, W.1    Stohl, W.2    Merrill, J.T.3
  • 19
    • 77955640361 scopus 로고    scopus 로고
    • LBSL02 Study Group. Progressive normalization of autoantibody, immunoglobulin, and complement levels over 2.5 years of Belimumab therapy in SLE patients
    • Abstract 426
    • Stohl W, Chatham W, Mckay J et al.; LBSL02 Study Group. Progressive normalization of autoantibody, immunoglobulin, and complement levels over 2.5 years of Belimumab therapy in SLE patients. Ann. Rheum. Dis. 56, S210 (2007) (Abstract 426).
    • (2007) Ann. Rheum. Dis. , vol.56
    • Stohl, W.1    Chatham, W.2    McKay, J.3
  • 20
    • 48649099799 scopus 로고    scopus 로고
    • LBSL02/99 Study Group. Safety profile of belimumab in patients with SLE treated during a placebo controlled trial and in a long term continuation study
    • Abstract 427
    • Merrill JT, Wallace DJ, Stohl W et al.; LBSL02/99 Study Group. Safety profile of belimumab in patients with SLE treated during a placebo controlled trial and in a long term continuation study. Arthritis Rheum. 56, S210 (2007) (Abstract 427).
    • (2007) Arthritis Rheum. , vol.56
    • Merrill, J.T.1    Wallace, D.J.2    Stohl, W.3
  • 21
    • 77955624126 scopus 로고    scopus 로고
    • Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: Efficacy and safety results from the Phase III BLISS-52 study
    • 17-21 October
    • Navarra S, Guzman R, Gallacher A et al.: Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: efficacy and safety results from the Phase III BLISS-52 study. Presented at: 73rdAnnual Scientific Meeting of the American College of Rheumatology. PA, USA, 17-21 October 2009.
    • (2009) Presented At: 73rdAnnual Scientific Meeting of the American College of Rheumatology. PA, USA
    • Navarra, S.1    Guzman, R.2    Gallacher, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.