Heritability of renal function and inflammatory markers in adult male twins

American Journal of Nephrology

Volumn 32, Issue 4, 2010, Pages 317-323

  Raggi, Paolo ^a,b   Su, Shaoyong ^a,b   Karohl, Cristina ^a,b   Veledar, Emir ^a,b   Rojas Campos, Enrique ^a   Vaccarino, Viola ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Heritability; Inflammation; Renal function

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6 RECEPTOR; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ADULT; ARTICLE; BODY MASS; CELL ACTIVATION; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DIZYGOTIC TWINS; ENDOTHELIUM CELL; GENETIC ANALYSIS; GLOMERULUS FILTRATION RATE; HEREDITY; HUMAN; HYPERTENSION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SMOKING; TWINS;

BIOLOGICAL MARKERS; ENVIRONMENT; GLOMERULAR FILTRATION RATE; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; MALE; MIDDLE AGED; MODELS, THEORETICAL; P-SELECTIN; RECEPTORS, INTERLEUKIN-6; RECEPTORS, TUMOR NECROSIS FACTOR; TWINS;

EID: 77955646945     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000319449     Document Type: Article

References (24)

1. Shlipak MG, Fried LF, Crump C, Bleyer AJ, Manolio TA, Tracy RP, Furberg CD, Psaty BM: Elevations of inflammatory and proco-agulant biomarkers in elderly persons with renal insufficiency. Circulation 2003; 107: 87-92.
2. Stam F, van Guldener C, Schalkwijk CG, ter Wee PM, Donker AJ, Stehouwer CD: Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity. Nephrol Dial Transplant 2003; 18 : 892-898.
3. Nelson CL, Karschimkus CS, Dragicevic G, Packham DK, Wilson AM, O'Neal D, Becker GJ, Best JD, Jenkins AJ: Systemic and vascular inflammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function. Nephrol Dial Transplant 2005; 20: 2420-2426.
4. Keller CR, Odden MC, Fried LF, Newman AB, Angleman S, Green CA, Cummings SR, Harris TB, Shlipak MG: Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study. Kidney Int 2007; 71: 239-24 4 .
5. Keller C, Katz R, Cushman M, Fried LF, Shlipak M: Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the multi-ethnic study of atherosclerosis (MESA). BMC Nephrol 2008; 9: 9.
6. Lin J, Glynn RJ, Rifai N, Manson JE, Ridker PM, Nathan DM, Schaumberg DA: Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial. Diabetes Care 2008; 31: 2338-2343.
7. Tonelli M, Sacks F, Pfeffer M, Jhangri GS, Curhan G: Biomarkers of inflammation and progression of chronic kidney disease. Kidney Int 2005; 68: 237-245. (Pubitemid 43181381)
8. Fava C, Montagnana M, Burri P, Almgren P, Minuz P, Hulthen UL, Melander O: Determinants of kidney function in Swedish families: role of heritable factors. J Hypertens 2008; 26: 1773-1779.
9. Hunter DJ, Lange M, Snieder H, MacGregor AJ, Swaminathan R, Thakker RV, Spector TD: Genetic contribution to renal function and electrolyte balance: a twin study. Clin Sci (Lond) 2002; 103:259-265.
10. Su S, Snieder H, Miller AH, Ritchie J, Brem-ner JD, Goldberg J, Dai J, Jones L, Murrah N V, Zhao J, Vaccarino V: Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis 2008; 200:213-220.
11. Goldberg J, Curran B, Vitek ME, Henderson WG, Boyko EJ: The Vietnam era twin registry. Twin Res 2002; 5:476-481.
12. Vaccarino V, Brennan ML, Miller AH, Bremner JD, Ritchie JC, Lindau F, Veledar E, Su S, Murrah NV, Jones L, Jawed F, Dai J, Goldberg J, Hazen SL: Association of major depressive disorder with serum myeloperox-idase and other markers of inflammation: a twin study. Biol Psychiatry 2008; 64:476-483.
13. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.
14. Roberts WL: CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: laboratory tests available to assess inflammation-performance and standardization: a background paper. Circulation 2004; 110:e572-e576.
15. Neale MC, Boker SM, Xie G, Maes HH: Mx: Statistical Modeling, ed 6. Richmond, Virginia Commonwealth University Medical School, 2003.
16. MacGregor AJ, Snieder H, Schork NJ, Spec-tor TD: Twins. Novel uses to study complex traits and genetic diseases. Trends Genet 2000; 16 : 131-134 .
17. Bathum L , Fagnani C, Christiansen L , Chris-tensen K: Heritability of biochemical kidney markers and relation to survival in the elderly-results from a Danish population-based twin study. Clin Chim Acta 2004; 349: 143-150.
18. Fox CS, Yang Q, Cupples LA, Guo CY, Larson MG, Leip EP, Wilson PW, Levy D: Ge-nomewide linkage analysis to serum creati-nine, GFR, and creatinine clearance in a community-based population: the Framing-ham Heart Study. J Am Soc Nephrol 2004; 15: 2457-2461.
19. Langefeld CD, Beck SR, Bowden DW, Rich SS, Wagenknecht LE, Freedman BI: Herita-bility of GFR and albuminuria in Caucasians with type 2diabetes mellitus. Am J Kidney Dis 2004; 43: 796-80 0 .
20. Muntner P, Hamm LL, Kusek JW, Chen J, Whelton PK, He J: The prevalence of nontra-ditional risk factors for coronary heart disease in patients with chronic kidney disease. Ann Intern Med 2004; 14 0 : 9-17.
21. Stenvinkel P, Lindholm B, Heimburger M, Heimburger O: Elevated serum levels of soluble adhesion molecules predict death in pre-dialysis patients: association with malnutrition, inf lammation, and cardiovascular disease. Nephrol Dial Transplant 2000; 15: 1624-1630.
22. Suliman ME, Qureshi AR, Heimburger O, Lindholm B, Stenvinkel P: Soluble adhesion molecules in end-stage renal disease: a predictor of outcome. Nephrol Dial Transplant 2006; 21:1603-1610.
23. Hauser IA, Riess R, Hausknecht B, Thurin-ger H, Sterzel RB: Expression of cell adhesion molecules in primary renal disease and renal allograft rejection. Nephrol Dial Transplant 1997; 12:1122-1131.
24. Peyser PA, Bielak LF, Chu JS, Turner ST, Ellsworth DL, Boerwinkle E, Sheedy PF: Herita-bility of coronary artery calcium quantity measured by electron bean computed tomography in asymptomatic adults. Circulation 2002; 10 6 : 304-308.