A systematic review of the efficacy and safety of Teucrium species; from anti-oxidant to anti-diabetic effects

International Journal of Pharmacology

Volumn 6, Issue 4, 2010, Pages 315-325

  Hasani Ranjbar, Shirin ^a   Nayebi, Neda ^a   Larijani, Bagher ^a   Abdollahi, Mohammad ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes; Oxidative stress; Systematic review; Teucrium

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; CHOLESTEROL; FLAVONOID; GLICLAZIDE; GLUCOSE; HERBACEOUS AGENT; LIPID; LIVER ENZYME; MORPHINE; PHYTOSTEROL; PLANT EXTRACT; TEUCRIUM CARTAGINENSES EXTRACT; TEUCRIUM DIVARIACTUM EXTRACT; TEUCRIUM FLAVUM EXTRACT; TEUCRIUM POLIUM EXTRACT; TEUCRIUM PUMILLIUM EXTRACT; TEUCRIUM STOCKSIANUM EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CHOLESTASIS; CHOLESTEROL BLOOD LEVEL; CHRONIC TOXICITY; DIABETES MELLITUS; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG WITHDRAWAL; FEVER; GERMANDER; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPOGLYCEMIA; INTRAHEPATIC CHOLESTASIS; JAUNDICE; LIPID BLOOD LEVEL; LIVER INJURY; LIVER TOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PAW EDEMA; SIDE EFFECT; STOMACH ULCER; SYSTEMATIC REVIEW; TEUCRIUM BUXIFOLIUM; TEUCRIUM CAPITATUM; TEUCRIUM CHAMAEDRYS; TEUCRIUM CUBENSE; TEUCRIUM DIVARIACTUM; TEUCRIUM MULTICAULE; TEUCRIUM PERSICUM; TEUCRIUM VISCIDUM; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 77955624903     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2010.315.325     Document Type: Article

References (85)

1. Abdolghaffari A.H., A. Baghaei, F. Moayer, H. Esmaily and M. Baeeri et al., 2010. On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators. Hum. Exp. Toxicol., (In Press).
2. Abdollahi, M., B. Larijani, R. Rahimi and P. Salari, 2005. Role of oxidative stress in osteoporosis. Therapy, 2: 787-796.
3. Abdollahi, M., A. Salehnia, S.H.R. Mortazavi, M. Ebrahimi and A. Shafiee etal., 2003a. Antioxidant, antidiabetic, antihyperlipidemic, reproduction stimulatory properties and safety of Satureja Khuzestanica essential oil as in rat in vivo: A toxicopharmacological study. Med. Sci. Monitor, 9: 331-335.
4. Abdollahi, M., H. Karimpour andH.R. Monsef-Esfehani, 2003b. Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacol. Res., 48: 31-35.
5. Afifi, F.U., B. Al-Khalidi and E. Khalil, 2005. Studies on the in vivo hypoglycemic activities of two medicinal plants used in the treatment of diabetes in Jordanian traditional medicine following intranasal administration. J. Ethnopharmacol., 100: 314-318.
6. Aghazadeh, S. and R. Yazdanparast, 2009. Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clin. Nutr., (In Press). 10.1016/j.clnu.2009.08.014
7. Al-Ashban, R.M., D.A. Barrett and A.H. Shah, 2005. Effects of chronic treatment with ethanolic extract of Teucrium polium in mice. J. Herbs Spices Med. Plants, 11: 27-36.
8. Amini, R. and R. Yazdanparast, 2009. Suppression of hepatic TNF-α and TGF-β gene expressions in rats with induced nonalcoholic steatohepatitis. Pharmacologyonline, 3: 340-350.
9. Amini, R., N. Nosrati, R. Yazdanparast and M. Molaei, 2009. Teucrium polium in prevention of steatohepatitis in rats. Liver Int., 29: 1216-1221.
10. Ansari, M., A.M. Alizadeh, M. Paknejad, M. Khaniki and S.M. Naeimi, 2009. Effects of Teucrium polium honey on burn wound healing process. J. Babol Univ. Med. Sci., 3: 7-12.
11. Ardestani, A., R. Yazdanparast and S.H. Jamshidi, 2008. Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats. J. Med. Food, 11: 525-532.
12. Atta-ur-Rahman, 2003. Studies in Natural Products Chemidtiy Bioactive Natural Products (Part I). 1st Edn., Elsevier, New York, ISBN-10: 0444514155. pp: 812.
13. Autore, G., F. Capasso and R. De Fusco, 1984. Antipyretic and antibacterial actions of Teucrium polium (L.). Pharmacol. Res. Commun., 16: 21-29.
14. Azaizeh, H., P. Ljubuncic, I. Portnaya, O. Said, U. Cogan and A. Bomzon, 2005. Fertilization-induced changes in growth parameters and antioxidant activity of medicinal plants used in traditional Arab medicine. Evid. Based Complement. Alternat. Med., 2: 549-556.
15. Baluchnejadmojarad, T., M. Roghani and F. Roghani-Dehkordi, 2005. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J. Ethnopharmacol., 97: 207-210.
16. Barrachina, M.D., R. Bello, M.A. Martinez-Cuesta, J. Esplugues and E. Primo-Yufera, 1995. Antiinflammatory activity and effects on isolated smooth muscle of extracts from different Teucrium species. Phytother. Res., 9: 368-371.
17. Beitran, B., R. Bello, S. Calatayud, L. Moreno, E. Primo-Yufera and J. Esplugues, 1998. Evaluation of the analgesic action of different fractions from the methanol extract of Teucrium buxifolium L. Phytother. Res., 12: 598-599.
18. Bello, R., M.D. Barrachina, M.A. Martlnez-Cuesta, J. Esplugues andE.P. Yufera, 1995. Evaluation of the acute toxicity, analgesic and CNS activities of different species of Teucrium genus. Phytother. Res., 9: 277-280.
19. Bello, R., S. Calatayud, L. Moreno, B. Beltra'n, E. Primo-Yu'fera and J. Esplugues, 1997. Effects on arterial blood pressure of the methanol extracts from different Teucrium species. Phytother. Res., 11: 330-331.
20. Bello, R., B. Beltra'n, L. Moreno, S. Calatayud, E. Primo-Yufera and J. Esplugues, 1998. Evaluation of the analgesic and CNS actions of different fractions from the methanol extract of Teucrium flavum L. Phytother. Res., 12: 65-67.
21. Ben Yahia, M., P. Mavier, J.M. Metreau, E.S. Zafrani and M. Fabre et al., 1993. A wild germander-induced chronic active hepatitis and cirrhosis: 3 cases. Gastroenterol. Clin. Biol., 17: 959-962.
22. Capasso, F., R. Cerri, P. Morrica and F. Senatore, 1983. Chemical composition and anti-inflammatory activity of an alcoholic extract of Teucrium polium L. Boll. Soc. Ital. Biol., 9: 1639-1643.
23. Castot, A. and D. Larrey, 1992. Acute hepatitis following administration of Germander-containing products: 26 Cases. Gastroenterol. Clm. Biol., 16: 916-922.
24. Catalayud, S., R. Bello, B. Beltra'n, E. Primo-Yu'fera and J. Esplugues, 1998a. Cardiovascular effects of the methanol and dichloromethanol extracts from Teucrium flavum L. Phytother. Res., 12: 68-69.
25. Catalayud, S., R. Bello, B. Beltra'n and E. Primo-Yufera, 1998b. Cardiovascular effects of the methanol and dichloromethanol extracts from Teucrium cartaginenses. Phytother. Res., 12: 44-45.
26. Chitturi, S. and G.C. Farrell, 2008. Hepatotoxic slimming aids and other herbal hepatotoxins. J. Gastroenterol. Hepatol., 23: 366-373.
27. De Miera Olivera, I.S., C.F. Marcos and F.S.R. Gonzalo, 2009. Ingestion of Teucrium chamaedrys infusions: Evidence of acute hepatitis after its reintroduction. Gastroenterol. Hepatol., 32: 70-71.
28. De Vincenzi, M., F. Maialetti and M. Silano, 2003. Constituents of aromatic plants: Teucrin A. Fitoterapia, 74: 746-749.
29. Dilsiz, N., A. Sahaboglu, M.Z. Yildiz and A. Reichenbach, 2006. Protective effects of various antioxidants during ischemia-reperfusion in the rat retina. Graefe's Arch. Clin. Exp. Ophthalmol., 244: 627-633.
30. Dourakis, S.P., I.S. Papanikolaou, E.N. Tzemanakis and S.J. Hadziyannis, 2002. Acute hepatitis associated with herb (Teucrium capitatum L.) administration. Eur. J. Gastroenterol. Hepatol., 14: 693-695.
31. Ellis, B.W., 1999. Taylor's Guide to Perennials. Houghton Mifflin Gardening, New York, pp: 445.
32. Esmaeili, M.A. andR. Yazdanparast, 2004. Hypoglycaemic effect of Teucrium polium. Studies with rat pancreatic islets. J. Ethnopharmacol., 1: 27-30.
33. Galati, E.M., R. Sanogo, O. Tzakou, A. Rossitto and M.P. Germano, 1997. Antiulcerogenic activity of Teucrium divaricatum Heldr. ssp. divaricatum. Phytother. Res., 11: 572-575.
34. Galati, E.M., M.R. Mondello, A. D'Aquino, N. Miceli, R. Sanogo, O. Tzakou and M.T. Monforte, 2000. Effects of Teucrium divaricatum Heldr. ssp. divaricatum decoction on experimental ulcer in rats. J. Ethnopharmacol., 72: 337-342.
35. Gharaibeh, M.N., H.H. Elayan and A.S. Salhab, 1988. Hypoglycemic effects of Teucrium polium. J. Ethnopharmacol., 24: 93-99.
36. Hasani, P., N. Yasa, S. Vosough-Ghanbari, A. Mohammadirad, G.H. Dehghan and M. Abdollahi, 2007. In vivo antioxidant potential of Teucrium polium, as compared to á-tocopherol. Acta Pharm., 57: 123-129.
37. Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2008. A systematic review of Iranian medicinal plants useful in diabetes mellitus. Arch. Med. Sci., 4, 3: 285-292.
38. Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2009. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm. Allergy Drug Targets, 8: 2-10.
39. Heidari, M.R., M. Karaminezhad-Ranjbar, E. Dadvand and S. Jalali, 1999. Evaluation of the analgesic effect of Teucrium polium extract in mice. J. Kerman Univ. Med. Sci., 2: 67-76.
40. Iriadam, M., 2004. Effects of vitamin C, artemisia herba alba and Teucrium polium on the blood glucose levels of rabbits. Indian Vet. J., 81: 880-882.
41. Islam, M.W., M.N.M. Zakaria, R. Radhakrishnan, M. Kamil, K.C. Chan and A. Al-Attas, 2002. Effect of Teucrium stocksianum on gastric ulc, eration and secretion in rats. Pharm. Biol., 40: 216-220.
42. Kadifkova-Panovska, T., S. Kulevanova and M. Stefova, 2005. In vitro antioxidant activity of some Teucrium species (Lamiaceae). Acta Pharm., 2: 207-214.
43. Karimi, F., S. Abbasi and A.R. Batem, 2002. The effect of Teucrium polium on blood glucose in diabetes mellitus type 2; A comparison with glibenclamide. Iran South Med. J., 2: 96-103.
44. Kim, J.D., S.M. Kang, M.Y. Park, T.Y. Jung, H.Y. Choi and S.K. Ku, 2007. Ameliorative anti-diabetic activity of dangnyosoko, a Chinese herbal medicine, in diabetic rats. Biosci. Biotechnol. Biochem., 71: 1527-1534.
45. Klepser, T.B. and M.E. Klepser, 1999. Unsafe and potentially safe herbal therapies. Am. J. Health. Syst. Pharm., 56: 125-138.
46. Konuklugil, B., G. Deniz, O. Yilcliz, S. Senoz and S. Saygi, 1997. Hypoglycemic effect of Teucrium polium in rats. J. Ethnopharmacol., 55: 93-98.
47. Kouzi, S.A., R.J. McMurtry and S.D. Nelson, 1994. Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse. Chem. Res. Toxicol., 7: 850-856.
48. Larrey, D., T. Vial, A. Pauwels, A. Castot, M. Biour, M. David and H. Michel, 1992. Hepatitis after germander (Teucrium chamaedrys) administration: Another instance of herbal medicine hepatotoxicity. Ann. Int. Med., 117: 129-132.
49. Ljubuncic, P., S. Dakwar, I. Portnaya, U. Cogan, H. Azaizeh and A. Bomzon, 2006. Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evid. Based Complement Alternat. Med., 3: 329-338.
50. Mazokopakis, E.E., J.A. Papadakis and D.P. Kofteridis, 2007. Unusual causes of intrahepatic cholestatic liver disease. World J. Gastroenterol., 13: 1879-1882.
51. Mehrabani, D., A. Rezaee, N. Azarpira, M.R. Fattahi and M. Amini et al., 2009. The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats. Saudi Med. J., 30: 494-499.
52. Mimidis, K.P., V.P. Papadopoulos, G. Baltatzidis, A. Giatromanolaki, E. Sivridis and G. Kartalis, 2009. Severe acute cholestasis caused by Teucrium poliu. J. Gastrointestin. Liver Dis., 18: 387-388.
53. Niazmand, S., M. Hajzadeh and Z. Keshavarzi-Poortafti, 2007. The effects of aqueous extract from Teucrium polium L. on rat gastric motility in basal and vagal-stimulated conditions. Iran. J. Basic Med. Sci., 1: 60-65.
54. Orhan, I. and M. Asian, 2009. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J. Ethnopharmacol., 122: 327-332.
55. Panovska, T.K., S. Kulevanova, I. Gjorgoski, M. Bogdanova and G. Petrushevska, 2007. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats. Acta Pharm., 57: 241-248.
56. Parsaei, H. and R. Shafiei Nik, 2006. Anti-spasmodic and anti-nociceptive effects of Teucrium polium aqueous extract. Iran. Biomed. J., 3: 149-145.
57. Pauwels, A., D. Thierman-Duffaud, J.M. Azanowsky, D. Loiseau, M. Biour and V.G. Levy, 1992. Wild Germander hepatitis; Hepatotoxicity of herbal remedies; Two cases. Gastroenterol. Clin. Biol., 16: 92-95.
58. Perez Alvarez, J.C., F. Sa'ez-Royuela, E.G. Pena, A.L. Morante, A. V. Ose's and J.L.M. Lorente, 2001. Acute hepatitis due to ingestion of Teucrium chamaedrys infusions. Gastroenterolog. Hepatolog., 24: 240-243.
59. Poon, W.T., T.L. Chau, C.K. Lai, K.Y. Tse, Y.C. Chan, K.S. Leung and Y.W. Chan, 2008. Hepatitis induced by Teucrium viscidum. Clin. Toxicol. (Phila), 46: 819-822.
60. Puntero, B.F., I.I. Peinado and A. Ma Villar del Fresno, 1997. Anti-inflammatory and antiulcer activity of Teucrium buxifolium. Am. J. Ethnopharmacol., 55: 93-98.
61. Radhakrishnan, R., M.N.M. Zakaria, M.W. Islam, M. Kamil, A. Ismail, K. Chan and A. Al-Attas, 2001. Analgesic and anti-inflammatory activities of Teucrium stocksianum. Pharm. Biol., 6: 455-459.
62. Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi, 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother., 59: 365-373.
63. Rahimi, R., S. Ghiasi, H. Azimi, S. Fakhari and M. Abdollahi, 2010. A review of the herbal phosphodiesterase inhibitors: Future perspective of new drugs. Cytokine, 49: 123-129.
64. Rasekh, H.R., M.J.K. Mansourkhani and M. Kamalinejad, 2001. Hypolipidemic effects of Teucrium polium in rats. Fitoterapia, 72: 937-939.
65. Rasekh, H.R., H. Yazdanpanah, L. Hosseinzadeh, N. Bazmohammadi and M. Kamalinejad, 2005. Acute and subchronic toxicity of Teucrium polium total extract in rats. Iran J. Pharm. Res., 4: 245-249.
66. Rasheed, R.A., B.H. Ali and A.K. Bashir, 1995. Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice. General Pharmacol., 26: 297-301.
67. Rezaie, A., R.D. Parker andM. Abdollahi, 2007. Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause? Dig. Dis. Sci., 52: 2015-2021.
68. Roman-Ramos, R., J.L. Flores-Saenz, G. Partida-Hernandez, A. Lara-Lemus and F. Alarcon-Aguilar, 1991. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch. Invest. Med., 22: 87-93.
69. Sadighi, J., F., Maftoon and M. Moshrefi, 2004. Complementary and alternative medicine (CAM): Knowledge, attitude and practice in Tehran, Iran. Payesh, 4: 289-279.
70. Sarkhail, P., S. Rahmanipour, S. Fadyevatan, A. Mohammadirad and G. Dehghan et al., 2007. Antidiabetic effect of Phlomis anisodonta. Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Pharmacol. Res., 56: 261-266.
71. Savvidou, S., J. Goulis, I. Giavazis, K. Patsiaoura, P. Hytiroglou and C. Arvanitakis, 2007. Herb-induced hepatitis by Teucrium polium L.: report of two cases and review of the literature. Eur. J. Gastroenterol. Hepatol., 19: 507-511.
72. Shahraki, M.R., E. Mm-Moghadam and M.J. Palan, 2006a. The survey of Teucrium polium toxicity effect on liver and serum lipoproteins in normoglycemic male rats. Tabib-E-Shargh, 3: 227-232.
73. Shahraki, M.R., H. MirShekan and M.J. Palan, 2006b. The comparison of nociceptive effect of Teucrium polium and morphine in female rats. Ofogh-E-Danesh, 1: 10-13.
74. Shahraki, M.R., M.R. Arab, E. Mirimokaddam and M.J. Palan, 2007. The effect of Teucrium polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats. Iran Biomed. J., 11: 65-68.
75. Shakhanbeh, J. and O. Atrouse, 2001. Teucrium polium inhibits nerve conduction and carrageenan-induced inflammation in the rat skin. Turk. J. Med. Sci., 31: 15-21.
76. Soylu, A.R., B. Sivn and Y. Bayraktar, 1998. Hepatoxicity of Teucrium polium. Turk. J. Gastroenterol., 9: 196-197.
77. Starakis, I., D. Siagris, L. Leonidou, E. Mazokopakis, A. Tsamandas and C. Karatza, 2006. Hepatitis caused by the herbal remedy Teucrium polium L. Eur. J. Gastroenterol. Hepatol., 18: 681-683.
78. Sundaresan, P.R., S.A. Slavoff, E. Grundel, K.D. White, E. Mazzola, D. Koblenz and J.I. Rader, 2006. Isolation and characterization of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC-mS and NMR. Phytochem. Analysid, 17: 243-250.
79. Tanira, M.O.M., I.A. Wasfi, M.A. Homsi and A.K. Bashir, 1996. Neuromuscular and microvascular changes associated with chronic administration of an extract of Teucrium stocksianum in mice. J. Pharm. Pharmacol, 48: 1098-1102.
80. Tanira, M.O.M., B.H. All, A.K. Bashir, F.F. El-Sabban and M. Al Homsi, 1997. Neuromuscular and microvascular changes associated with chronic administration of an extract of Teucrium stocksianum in mice. J. Pharm. Pharmacol., 49: 301-304.
81. Tariq, M., A.M. Ageel, M.A. Al-Yahya, J.S. Mossa and M.S. Al-Said, 1989. Anti-inflammatory activity of Teucrium polium. Int. J. Tissue React., 11: 185-188.
82. Vessal, M., F. Zal and M. Vasei, 2003. Effects of Teucrium polium on oral glucose tolerance test, regeneration of pancreatic islets and activity of hepatic glucokinase in diabetic rats. Arch. Iran Med., 6: 35-39.
83. Wasfi, I.A., A.K. Bashir, M.H. Amin, A. A. Abdalla, N.R. Banna and M.O.M. Tanira, 1995. Gastric cytoprotective activity of Teucrium stocksianum extract in rats. Int. J. Pharmacog., 33: 164-171.
84. Yazdanparast, R., M.A. Esmaeilil and J. Ashrafi-Helan, 2005. Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: A histopathological examination. Iran. Biomedical. J., 9: 81-85.
85. Zal, F., M. Vasei, M. Rasti and M. Vessal, 2001. Hepatotoxicity associated with hypoglycemic effects of Teucrium polium in diabetic rats. Arch. Iran Med., 4: 188-192.