In vivo selection of aac(6′)-Ib-cr and mutations in the gyrA gene in a clinical qnrS1-positive Salmonella enterica serovar Typhimurium DT104B strain recovered after fluoroquinolone treatment

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 9, 2010, Pages 1945-1949

  de Toro, María ^a,b   Rojo Bezares, Beatriz ^a   Vinué, Laura ^b   Undabeitia, Esther ^c   Torres, Carmen ^a,b   Sáenz, Yolanda ^a  

^a CENTER FOR BIOMEDICAL RESEARCH OF LA RIOJA CIBIR   (Spain)

^b UNIVERSITY OF LA RIOJA   (Spain)

^c HOSPITAL SAN PEDRO   (Spain)

Author keywords

Class 1 integrons; Multilocus sequence typing; Plasmid mediated quinolone resistance mechanisms; Plasmids

Indexed keywords

AMIKACIN; CIPROFLOXACIN; KANAMYCIN; LEVOFLOXACIN; NALIDIXIC ACID; OFLOXACIN; QUINOLONE DERIVATIVE; STREPTOMYCIN; SULFONAMIDE; TETRACYCLINE; TOBRAMYCIN; TRIMETHOPRIM;

AGED HOSPITAL PATIENT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; GASTROENTERITIS; GENE CASSETTE; GENE SEQUENCE; GENE STRUCTURE; GYRA GENE; IN VIVO STUDY; INTEGRON; MULTILOCUS SEQUENCE TYPING; MUTATION; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SEROTYPE;

EID: 77955620305     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq262     Document Type: Article

References (11)

1. Giraud E, Baucheron S, Cloeckaert A. Resistance to fluoroquinolones in Salmonella: emerging mechanisms and resistance prevention strategies. Microbes Infect 2006; 8: 1937-44.
2. Martińez-Martínez L, Cano ME, Rodríuez-Martínez JM et al. Plasmid-mediated quinolone resistance. Expert Rev Anti Infect Ther 2008; 6: 685-711.
3. Cattoir V, Nordmann P. Plasmid-mediated quinolone resistance in Gramnegative bacterial species: an update. Curr Med Chem 2009; 16: 1028-46.
4. Gunell M, Webber MA, Kotilainen P et al. Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. Antimicrob Agents Chemother 2009; 53: 3832-6.
5. Strahilevitz J, Jacoby GA, Hooper DC et al. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev 2009; 22: 664-89.
6. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Eighteenth Informational Supplement M100-S18. CLSI, Wayne, PA, USA, 2008.
7. Kehrenberg C, Hopkins KL, Threlfall EJ et al. Complete nucleotide sequence of a small qnrS1-carrying plasmid from Salmonella enterica subsp. enterica Typhimurium DT193. J Antimicrob Chemother 2007; 60:903-5.
8. Poirel L, Cattoir V, Soares A et al. Novel Ambler class A β-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. Antimicrob Agents Chemother 2007; 51: 631-7.
9. García-Fernández A, Fortini D, Veldman K et al. Characterization of plasmids harbouring qnrS1, qnrB2 and qnrB19 genes in Salmonella. J Antimicrob Chemother 2009; 63: 274-81.
10. Poirel L, Pitout JD, Calvo L et al. In vivo selection of fluoroquinolone-resistant Escherichia coli isolates expressing plasmid-mediated quinolone resistance and expanded-spectrum β-lactamase. Antimicrob Agents Chemother 2006; 50: 1525-7.
11. Vinué L, Sáenz Y, Rojo-Bezares B et al. Genetic environment of sul genes and characterization of integrons in Escherichia coli isolates from blood origin in a Spanish Hospital. Int J Antimicrob Agents 2010; 35: 492-6.