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Volumn 5, Issue 7, 2010, Pages

Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADOTROPIN; KISSPEPTIN; KISSPEPTIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

EID: 77955612080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011911     Document Type: Article
Times cited : (74)

References (44)
  • 2
    • 32644439450 scopus 로고    scopus 로고
    • Minireview: The neuroendocrine regulation of puberty: Is the time ripe for a systems biology approach?
    • Ojeda SR, Lomniczi A, Mastronardi C, Heger S, Roth C, et al. (2006) Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? Endocrinology 147: 1166-1174.
    • (2006) Endocrinology , vol.147 , pp. 1166-1174
    • Ojeda, S.R.1    Lomniczi, A.2    Mastronardi, C.3    Heger, S.4    Roth, C.5
  • 3
    • 62649100136 scopus 로고    scopus 로고
    • Kisspeptins and GnRH neuronal signalling
    • Colledge WH (2009) Kisspeptins and GnRH neuronal signalling. Trends Endocrinol Metab 20: 115-121.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 115-121
    • Colledge, W.H.1
  • 4
    • 13444255980 scopus 로고    scopus 로고
    • Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    • Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, et al. (2005) Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A 102: 1761-1766.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1761-1766
    • Messager, S.1    Chatzidaki, E.E.2    Ma, D.3    Hendrick, A.G.4    Zahn, D.5
  • 5
    • 34748900269 scopus 로고    scopus 로고
    • Kiss1-/-mice exhibit more variable hypogonadism than Gpr54-/- mice
    • Lapatto R, Pallais JC, Zhang D, Chan YM, Marian A, et al. (2007) Kiss1-/-mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology 148: 4927-4936.
    • (2007) Endocrinology , vol.148 , pp. 4927-4936
    • Lapatto, R.1    Pallais, J.C.2    Zhang, D.3    Chan, Y.M.4    Marian, A.5
  • 6
    • 4644289298 scopus 로고    scopus 로고
    • Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    • Navarro VM, Castellano JM, Fernandez-Fernandez R, Barreiro ML, Roa J, et al. (2004) Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145: 4565-4574.
    • (2004) Endocrinology , vol.145 , pp. 4565-4574
    • Navarro, V.M.1    Castellano, J.M.2    Fernandez-Fernandez, R.3    Barreiro, M.L.4    Roa, J.5
  • 7
    • 33751538038 scopus 로고    scopus 로고
    • Postnatal development ofkisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons
    • Clarkson J, Herbison AE (2006) Postnatal development ofkisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology 147: 5817-5825.
    • (2006) Endocrinology , vol.147 , pp. 5817-5825
    • Clarkson, J.1    Herbison, A.E.2
  • 8
    • 10644284011 scopus 로고    scopus 로고
    • Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand ofGPR54
    • Navarro VM, Fernandez-Fernandez R, Castellano JM, Roa J, Mayen A, et al. (2004) Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand ofGPR54. J Physiol 561: 379-386.
    • (2004) J Physiol , vol.561 , pp. 379-386
    • Navarro, V.M.1    Fernandez-Fernandez, R.2    Castellano, J.M.3    Roa, J.4    Mayen, A.5
  • 10
    • 22144455384 scopus 로고    scopus 로고
    • Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse
    • Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, et al. (2005) Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146: 2976-2984.
    • (2005) Endocrinology , vol.146 , pp. 2976-2984
    • Smith, J.T.1    Dungan, H.M.2    Stoll, E.A.3    Gottsch, M.L.4    Braun, R.E.5
  • 11
    • 50449101532 scopus 로고    scopus 로고
    • Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy
    • Ramaswamy S, Guerriero KA, Gibbs RB, Plant TM (2008) Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology 149: 4387-4395.
    • (2008) Endocrinology , vol.149 , pp. 4387-4395
    • Ramaswamy, S.1    Guerriero, K.A.2    Gibbs, R.B.3    Plant, T.M.4
  • 12
    • 33947363962 scopus 로고    scopus 로고
    • Sexual differentiation of Kiss1 gene expression in the brain of the rat
    • Kaufman AS, Gottsch ML, Roa J, Byquist AC, Crown A, et al. (2007) Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148: 1774-1783.
    • (2007) Endocrinology , vol.148 , pp. 1774-1783
    • Kaufman, A.S.1    Gottsch, M.L.2    Roa, J.3    Byquist, A.C.4    Crown, A.5
  • 13
    • 33646770966 scopus 로고    scopus 로고
    • Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat
    • Roa J, Vigo E, Castellano JM, Navarro VM, Fernandez-Fernandez R, et al. (2006) Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat. Endocrinology 147: 2864-2878.
    • (2006) Endocrinology , vol.147 , pp. 2864-2878
    • Roa, J.1    Vigo, E.2    Castellano, J.M.3    Navarro, V.M.4    Fernandez-Fernandez, R.5
  • 14
    • 34248383233 scopus 로고    scopus 로고
    • Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    • Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, et al. (2007) Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53: 367-378.
    • (2007) J Reprod Dev , vol.53 , pp. 367-378
    • Adachi, S.1    Yamada, S.2    Takatsu, Y.3    Matsui, H.4    Kinoshita, M.5
  • 15
    • 0023023132 scopus 로고
    • A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse
    • Mason AJ, Hayflick JS, Zoeller RT, Young WS, 3rd, Phillips HS, et al. (1986) A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234: 1366-1371.
    • (1986) Science , vol.234 , pp. 1366-1371
    • Mason, A.J.1    Hayflick, J.S.2    Zoeller, R.T.3    Young III, W.S.4    Phillips, H.S.5
  • 16
    • 0017655350 scopus 로고
    • Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
    • Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G (1977) Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269: 338-340.
    • (1977) Nature , vol.269 , pp. 338-340
    • Cattanach, B.M.1    Iddon, C.A.2    Charlton, H.M.3    Chiappa, S.A.4    Fink, G.5
  • 17
    • 67649665605 scopus 로고    scopus 로고
    • Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset
    • Clarkson J, Boon WC, Simpson ER, Herbison AE (2009) Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology.
    • (2009) Endocrinology
    • Clarkson, J.1    Boon, W.C.2    Simpson, E.R.3    Herbison, A.E.4
  • 18
    • 73949110561 scopus 로고    scopus 로고
    • Maturation of kisspeptinergic neurons coincides with puberty onset in male rats
    • Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, et al. (2009) Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides 31: 275-283.
    • (2009) Peptides , vol.31 , pp. 275-283
    • Bentsen, A.H.1    Ansel, L.2    Simonneaux, V.3    Tena-Sempere, M.4    Juul, A.5
  • 19
    • 0029339431 scopus 로고
    • Effects of gonadotropin administration on follicular growth and in vitro fertilization in female hypogonadal mice
    • Hashizume K, Tsujii H, Rokutanda M (1995) Effects of gonadotropin administration on follicular growth and in vitro fertilization in female hypogonadal mice. Exp Anim 44: 241-244.
    • (1995) Exp Anim , vol.44 , pp. 241-244
    • Hashizume, K.1    Tsujii, H.2    Rokutanda, M.3
  • 20
    • 77953916840 scopus 로고    scopus 로고
    • Coming of age in the Kisspeptin Era: Sex differences, development, and puberty
    • Kauffman AS (2010) Coming of age in the Kisspeptin Era: Sex differences, development, and puberty. Mol Cell Endocrinol 324: 51-63.
    • (2010) Mol Cell Endocrinol , vol.324 , pp. 51-63
    • Kauffman, A.S.1
  • 21
    • 34548089414 scopus 로고    scopus 로고
    • The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior
    • Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, et al. (2007) The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci 27: 8826-8835.
    • (2007) J Neurosci , vol.27 , pp. 8826-8835
    • Kauffman, A.S.1    Park, J.H.2    McPhie-Lalmansingh, A.A.3    Gottsch, M.L.4    Bodo, C.5
  • 22
    • 70350443234 scopus 로고    scopus 로고
    • Sex Differences in the Regulation of Kiss1/NKB Neurons in Juvenile Mice: Implications for the Timing of Puberty
    • Kauffman AS, Navarro VM, Kim J, Clifton D, Steiner RA (2009) Sex Differences in the Regulation of Kiss1/NKB Neurons in Juvenile Mice: Implications for the Timing of Puberty. Am J Physiol Endocrinol Metab 297: 1212-1221.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. 1212-1221
    • Kauffman, A.S.1    Navarro, V.M.2    Kim, J.3    Clifton, D.4    Steiner, R.A.5
  • 23
    • 65849335621 scopus 로고    scopus 로고
    • Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression in discrete hypothalamic areas of female rats
    • Takase K, Uenoyama Y, Inoue N, Matsui H, Yamada S, et al. (2009) Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression in discrete hypothalamic areas of female rats. J Neuroendocrinol 21: 527-537.
    • (2009) J Neuroendocrinol , vol.21 , pp. 527-537
    • Takase, K.1    Uenoyama, Y.2    Inoue, N.3    Matsui, H.4    Yamada, S.5
  • 24
    • 48949093672 scopus 로고    scopus 로고
    • Unique responses of midbrain CART neurons in macaques to ovarian steroids
    • Lima FB, Henderson JA, Reddy AP, Tokuyama Y, Hubert GW, et al. (2008) Unique responses of midbrain CART neurons in macaques to ovarian steroids. Brain Res 1227: 76-88.
    • (2008) Brain Res , vol.1227 , pp. 76-88
    • Lima, F.B.1    Henderson, J.A.2    Reddy, A.P.3    Tokuyama, Y.4    Hubert, G.W.5
  • 25
    • 0028232262 scopus 로고
    • Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty
    • Ma YJ, Hill DF, Junier MP, Costa ME, Felder SE, et al. (1994) Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty. Mol Cell Neurosci 5: 246-262.
    • (1994) Mol Cell Neurosci , vol.5 , pp. 246-262
    • Ma, Y.J.1    Hill, D.F.2    Junier, M.P.3    Costa, M.E.4    Felder, S.E.5
  • 26
    • 52049083005 scopus 로고    scopus 로고
    • Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    • Clarkson J, d'Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE (2008) Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 28: 8691-8697.
    • (2008) J Neurosci , vol.28 , pp. 8691-8697
    • Clarkson, J.1
  • 27
    • 77950926407 scopus 로고    scopus 로고
    • Effects ofaromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones
    • Bakker J, Pierman S, Gonzalez-Martinez D (2010) Effects ofaromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Horm Behav 57: 390-395.
    • (2010) Horm Behav , vol.57 , pp. 390-395
    • Bakker, J.1    Pierman, S.2    Gonzalez-Martinez, D.3
  • 28
    • 42449122715 scopus 로고    scopus 로고
    • Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: Prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges
    • Gonzalez-Martinez D, De Mees C, Douhard Q, Szpirer C, Bakker J (2008) Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges. Endocrinology 149: 2333-2340.
    • (2008) Endocrinology , vol.149 , pp. 2333-2340
    • Gonzalez-Martinez, D.1    de Mees, C.2    Douhard, Q.3    Szpirer, C.4    Bakker, J.5
  • 29
    • 25144488534 scopus 로고    scopus 로고
    • Gonadotropin control of inhibin secretion and the relationship to follicle type and number in the hpg mouse
    • Wang Y, Newton H, Spaliviero JA, Allan CM, Marshan B, et al. (2005) Gonadotropin control of inhibin secretion and the relationship to follicle type and number in the hpg mouse. Biol Reprod 73: 610-618.
    • (2005) Biol Reprod , vol.73 , pp. 610-618
    • Wang, Y.1    Newton, H.2    Spaliviero, J.A.3    Allan, C.M.4    Marshan, B.5
  • 30
    • 0030928779 scopus 로고    scopus 로고
    • Endocrine defects in mice carrying a null mutation for the progesterone receptorgene
    • Chappell PE, Lydon JP, Conneely OM, O'Malley BW, Levine JE (1997) Endocrine defects in mice carrying a null mutation for the progesterone receptorgene. Endocrinology 138: 4147-4152.
    • (1997) Endocrinology , vol.138 , pp. 4147-4152
    • Chappell, P.E.1    Lydon, J.P.2    Conneely, O.M.3    O'Malley, B.W.4    Levine, J.E.5
  • 31
    • 70849108550 scopus 로고    scopus 로고
    • Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats
    • Homma T, Sakakibara M, Yamada S, Kinoshita M, Iwata K, et al. (2009) Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats. Biol Reprod 81: 1216-1225.
    • (2009) Biol Reprod , vol.81 , pp. 1216-1225
    • Homma, T.1    Sakakibara, M.2    Yamada, S.3    Kinoshita, M.4    Iwata, K.5
  • 32
    • 0016491406 scopus 로고
    • A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis
    • Conte FA, Grumbach MM, Kaplan SL (1975) A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis. J Clin Endocrinol Metab 40: 670-674.
    • (1975) J Clin Endocrinol Metab , vol.40 , pp. 670-674
    • Conte, F.A.1    Grumbach, M.M.2    Kaplan, S.L.3
  • 33
    • 1342306108 scopus 로고    scopus 로고
    • Neurobiological mechanisms of puberty in higher primates
    • Plant TM, Barker-Gibb ML (2004) Neurobiological mechanisms of puberty in higher primates. Hum Reprod Update 10: 67-77.
    • (2004) Hum Reprod Update , vol.10 , pp. 67-77
    • Plant, T.M.1    Barker-Gibb, M.L.2
  • 34
    • 0019809702 scopus 로고
    • The maturation ofestradiol-negative feedback in female rats: Evidence that the resetting of the hypothalamic ''gonadostat'' does not precede the first preovulatory surge of gonadotropins
    • Andrews WW, Advis JP, Ojeda SR (1981) The maturation ofestradiol-negative feedback in female rats: evidence that the resetting of the hypothalamic ''gonadostat'' does not precede the first preovulatory surge of gonadotropins. Endocrinology 109: 2022-2031.
    • (1981) Endocrinology , vol.109 , pp. 2022-2031
    • Andrews, W.W.1    Advis, J.P.2    Ojeda, S.R.3
  • 35
    • 0000044223 scopus 로고
    • Comparison of the regulation of luteinizing hormone (LH) secretion in immature and adult rats
    • Ramirez DV, Mc CS (1963) Comparison of the regulation of luteinizing hormone (LH) secretion in immature and adult rats. Endocrinology 72: 452-464.
    • (1963) Endocrinology , vol.72 , pp. 452-464
    • Ramirez, D.V.1    Mc, C.S.2
  • 36
    • 57849133466 scopus 로고    scopus 로고
    • Sexual differentiation and the Kiss1 system: Hormonal and developmental considerations
    • Kauffman AS (2009) Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides 30: 83-93.
    • (2009) Peptides , vol.30 , pp. 83-93
    • Kauffman, A.S.1
  • 37
    • 34447115135 scopus 로고    scopus 로고
    • Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
    • Rometo AM, Krajewski SJ, Voytko ML, Rance NE (2007) Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 92: 2744-2750.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2744-2750
    • Rometo, A.M.1    Krajewski, S.J.2    Voytko, M.L.3    Rance, N.E.4
  • 38
    • 57849167037 scopus 로고    scopus 로고
    • Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
    • Rance NE (2009) Menopause and the human hypothalamus: evidence for the role ofkisspeptin/neurokinin B neurons in the regulation ofestrogen negative feedback. Peptides 30: 111-122.
    • (2009) Peptides , vol.30 , pp. 111-122
    • Rance, N.E.1
  • 39
    • 56649096022 scopus 로고    scopus 로고
    • Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women
    • Rometo AM, Rance NE (2008) Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women. J Neuroendocrinol 20: 1376-1381.
    • (2008) J Neuroendocrinol , vol.20 , pp. 1376-1381
    • Rometo, A.M.1    Rance, N.E.2
  • 40
    • 29344462154 scopus 로고    scopus 로고
    • Alterations of arcuate nucleus neuropeptidergic development in contactin-deficient mice: Comparison with anorexia and food-deprived mice
    • Fetissov SO, Bergstrom U, Johansen JE, Hokfelt T, Schalling M, et al. (2005) Alterations of arcuate nucleus neuropeptidergic development in contactin-deficient mice: comparison with anorexia and food-deprived mice. Eur J Neurosci 22: 3217-3228.
    • (2005) Eur J Neurosci , vol.22 , pp. 3217-3228
    • Fetissov, S.O.1    Bergstrom, U.2    Johansen, J.E.3    Hokfelt, T.4    Schalling, M.5
  • 41
    • 4344561363 scopus 로고    scopus 로고
    • A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    • Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, et al. (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145: 4073-4077.
    • (2004) Endocrinology , vol.145 , pp. 4073-4077
    • Gottsch, M.L.1    Cunningham, M.J.2    Smith, J.T.3    Popa, S.M.4    Acohido, B.V.5
  • 42
    • 30544450474 scopus 로고    scopus 로고
    • Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty
    • Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, et al. (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25: 11349-11356.
    • (2005) J Neurosci , vol.25 , pp. 11349-11356
    • Han, S.K.1    Gottsch, M.L.2    Lee, K.J.3    Popa, S.M.4    Smith, J.T.5
  • 43
    • 21344471138 scopus 로고    scopus 로고
    • Real-time RT-PCR normalisation; strategies and considerations
    • Huggett J, Dheda K, Bustin S, Zumla A (2005) Real-time RT-PCR normalisation; strategies and considerations. Genes Immun 6: 279-284.
    • (2005) Genes Immun , vol.6 , pp. 279-284
    • Huggett, J.1    Dheda, K.2    Bustin, S.3    Zumla, A.4
  • 44
    • 4344564046 scopus 로고    scopus 로고
    • Comparison ofreverse transcriptases in gene expression analysis
    • Stahlberg A, Kubista M, Pfaffl M (2004) Comparison ofreverse transcriptases in gene expression analysis. Clin Chem 50: 1678-1680.
    • (2004) Clin Chem , vol.50 , pp. 1678-1680
    • Stahlberg, A.1    Kubista, M.2    Pfaffl, M.3


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