Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Clark, Tamara D ^a   Njama Meya, Denise ^b   Nzarubara, Bridget ^b   Maiteki Sebuguzi, Catherine ^b   Greenhouse, Bryan ^a   Staedke, Sarah G ^c   Kamya, Moses R ^b   Dorsey, Grant ^a   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; CLINDAMYCIN; FANSIDAR; HEMOGLOBIN; QUININE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ DERIVATIVE; BENFLUMETOL; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ANEMIA; ARTICLE; BED NET; CHILD; CHILD CARE; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; EVENING DOSAGE; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALE; OUTCOME ASSESSMENT; PLASMODIUM FALCIPARUM; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SCHOOL CHILD; SINGLE BLIND PROCEDURE; TREATMENT DURATION; UGANDA; URBAN POPULATION; DRUG COMBINATION; INFANT; PRESCHOOL CHILD; TREATMENT OUTCOME;

PLASMODIUM FALCIPARUM;

AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FEMALE; FLUORENES; HUMANS; INCIDENCE; INFANT; MALARIA; MALE; PYRIMETHAMINE; SULFADOXINE; TREATMENT OUTCOME; UGANDA;

EID: 77955610483     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011759     Document Type: Article

References (26)

1. Greenwood BM, Bojang K, Whitty CJ, Targett TA (2005) Malaria. Lancet 365: 1487-98.
2. Kleinschmidt I, Sharp B, Benavente LE, Schwabe C, Torrez M, et al. (2006) Reduction in infection with Plasmodium falciparum one year after the introduction of malaria control interventions on Bioko Island, Equatorial Guinea. Am J Trop Med Hyg 74: 972-8.
3. Bhattarai A, Ali AS, Kachur SP, Ma°rtensson A, Abbas AK, et al. (2007) Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med 4: e309.
4. Ceesay SJ, Casals-Pascual C, Erskine J, Anya SE, Duah NO, et al. (2008) Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis. Lancet 372: 1545-54.
5. O'Meara WP, Bejon P, Mwangi TW, Okiro EA, Peshu N, et al. (2008) Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet 372: 1555-62.
6. Barnes KI, Chanda P, Ab Barnabas G (2009) Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia. Malar J 8 Suppl 1: S8.
7. Mutabingwa TK, Anthony D, Heller A, Hallett R, Ahmed J, et al. (2005) Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+ artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet 365: 1474-80.
8. Martensson A, Stromberg J, Sisowath C, Msellem MI, Gil JP, et al. (2005) Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. Clin Infect Dis 41: 1079-86.
9. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, et al. (2005) Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med 2: e190.
10. van den Broek I, Kitz C, Al Attas S, Libama F, Balasegaram M, et al. (2006) Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo. Malar J 5: 113.
11. Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, et al. (2006) Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials 1: e7.
12. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, et al. (2007) Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA 297: 2210-9.
13. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, et al. (2004) Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet 364: 1950-7.
14. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, et al. (2007) Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis 45: 1453-61.
15. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, et al. (2007) Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised noninferiority trial. Lancet 369: 491-8.
16. Zwang J, Olliaro P, Barennes H, Bonnet M, Brasseur P, et al. (2009) Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub- Saharan Africa: a multi-centre analysis. Malar J 8: 203.
17. Djimde AA, Doumbo OK, Traore O, Guindo AB, Kayentao K, et al. (2003) Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am J Trop Med Hyg 69: 558-63.
18. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, et al. (2006) Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis 193: 978-86.
19. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, et al. (2008) Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis 198: 393-400.
20. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, et al. (2009) Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis 199: 758-65.
21. Davis JC, Clark TD, Kemble SK, Talemwa N, Njama-Meya D, et al. (2006) Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment. Malar J 5: 18.
22. World Health Organization (2003) Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. Geneva: World Health Organization.
23. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, et al. (2008) Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J 7: 106.
24. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, et al. (2004) Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis 189: 2220-6.
25. Trape JF, Rogier C (1996) Combating malaria morbidity and mortality by reducing transmission. Parasitol Today 12: 236-40.
26. World Health Organization (2000) Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 94 Suppl 1: S1-90.