Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice

Inflammopharmacology

Volumn 18, Issue 4, 2010, Pages 197-207

  Pratheeshkumar, P ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Antioxidant; Chemoprotection; Cyclophosphamide; Toxicity; Vernonia cinerea

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA ESTERASE; CYCLOPHOSPHAMIDE; ESTERASE; GAMMA INTERFERON; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; LEDOXAN; METHANOL; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERNONIA CINEREA EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE INJURY; LEUKOCYTE COUNT; LIPID PEROXIDATION; LYMPHOID ORGAN; MOUSE; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; SMALL INTESTINE; SOLID TUMOR; TOXICITY TESTING; VERNONIA; VERNONIA CINEREA;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW CELLS; CYCLOPHOSPHAMIDE; CYTOKINES; DRUG EVALUATION, PRECLINICAL; IMMUNOSUPPRESSION; MICE; MICE, INBRED BALB C; NEOPLASMS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; VERNONIA;

EID: 77955601292     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-010-0042-8     Document Type: Article

References (54)

1. Abeysekera AM, De Silva KTD, De Silva SRP, Sirimanne VDP, Labadie RP, Van den Berg AJJ et al (1999) Inhibition of chemiluminescence generated by zymosan-activated polymorphonuclear leucocytes by phenolic constituents of Vernonia cinerea. Fitoterapia 70:317-319
2. GV Alexeeff R Broadwin J Liaw SV Dawson 2002 Characterization of the LOAEL-to-NOAEL uncertainty factor for mild adverse effects from acute inhalation exposures Regul Toxicol Pharmacol 36 96 105 10.1006/rtph.2002.1562 1:CAS:528:DC%2BD38Xntlygsbc%3D 12383722 (Pubitemid 36160148)
3. TM Alves TJ Nagem LV de Carvalho AV Krettl CL Zani, et al. 1997 Antiplasmodial triterpene from Vernonia brasiliani Planta Med 63 554 555 10.1055/s-2006-957764 1:STN:280:DyaK1c%2Fps1SqsA%3D%3D 9434611 (Pubitemid 28035456)
4. A Bajpai JK Ohja HR Sant 1995 Medicobotany of the Varanasi district Int J Pharmacogn 33 172 176 10.3109/13880209509055220
5. Bancroft JD, Cook HC (1984) Manual of histologic techniques. Churchill Living Stone, London, p 171
6. F Benoit A Valentine Y Pelessier F Diafuoka C Marion, et al. 1996 In vitro antimalarial activity of vegetal extracts used in West African traditional medicine Am J Trop Med Hyg 54 67 71 1:STN:280:DyaK283gslOksw%3D%3D 8651373
7. B Bentler A Cerami 1986 Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation Immunol Res 5 281 293 10.1007/BF02935501
8. Berger NA (1993) Alkylating agents. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology. J.B. Lippincott Company, Philadelphia, pp 403-409
9. Bergmeyer HU, Bernt E (1980) Colorimetric method for aspartate aniline aminotransferases. In: Varley H, Gowenlock AH, Bell M (eds) Practical clinical biochemistry, 5th edn. William Heinemann Medical Books Ltd, London
10. NK Bhattarai 1991 Folk herbal medicines of Makawanpur district, Nepal Int J Pharmacogn 29 284 295 10.3109/13880209109082899
11. B Bin-Haffeez I Ahmad R Haque S Raisuddin 2001 Protective effect of Cassia occidentalis L. on CTX induced suppression of humeral immunity in mice J Ethnopharmacol 75 13 18 10.1016/S0378-8741(00)00382-2 (Pubitemid 32224867)
12. L Borish LJ Rosenwasser 1996 Update on cytokines J Allergy Clin Immunol 97 719 734 10.1016/S0091-6749(96)80146-1 1:CAS:528:DyaK28Xitl2gsL8%3D 8613627 (Pubitemid 26089244)
13. R Bukowski 1999 The need for cytoprotection Eur J Cancer 32A S2 S4
14. P Chakraborty SKU Hossain N Murmu JK Das S Pal S Bhattacharya 2009 Modulation of cyclophosphamide-induced cellular toxicity by diphenylmethyl selenocyanate in vivo, an enzymatic study J Cancer Mol 4 183 189
15. Colvin OM (2001) Antitumor alkylating agents. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology. Lippincott Williams and Wilkins, Philadelphia, pp 363-376
16. P Desai 2007 Cytokines in obstetrics and gynaecology J Obstet Gynecol India 57 205 209 1:CAS:528:DC%2BD2sXhtFCksr7F
17. CA Dinarello JG Cannon SM Wolff 1986 Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of intedeuldn-1 J Exp Med 163 1433 1450 10.1084/jem.163.6.1433 1:CAS:528:DyaL28Xkt1arsr8%3D 3486936
18. Dollery C (1999) Therapeutic drugs. Churchill Livingstone, Edinburgh, pp C349-C354
19. RO Ehrhacat BR Ludviksson B Gray M Neurath W Strober 1997 Induction and prevention of chronic inflammation in IL-2 deficient mice J Immunol 158 566 571
20. LH Fraiser S Kanekel JP Kehrer 1991 Cyclophosphamide toxicity; characterizing and avoiding the problem Drug 42 781 795 10.2165/00003495- 199142050-00005 1:STN:280:DyaK387jslSluw%3D%3D
21. JC Gasson 1991 Molecular physiology of granulocyte-macrophage colony-stimulating factor Blood 77 1131 1145 1:CAS:528:DyaK3MXmt12ksrY%3D 2001448
22. CR Graigner 1996 Medicinal plants of Seychelles J R Soc Health 116 107 109 10.1177/146642409611600210
23. Growchow LB (1996) Covalent DNA-binding drugs. In: Perry MC (ed) The chemotherapy source book. Williams and Wilkins, Baltimore, pp 297-299
24. Hall IH, Lee KH, Starnes CO, Sumida Y, Wu Ry, Waddell TG, Cochran JW, Gerhart KG (1979) Anti-inflammatory activity of sesquiterpene lactones and related compounds. J Pharm Sci 68:537-542
25. R Haque B Bin Hafeez I Ahmed S Parvez S Pandey S Raisuddin 2001 Protective effects of Emblica officinalis Gaertn. in CTX-treated mice Hum Exp Toxicol 20 643 650 10.1191/096032701718890568 1:STN:280:DC%2BD383gsVWgtw%3D%3D 11936579 (Pubitemid 34308569)
26. R Haque B Bin-Hafeez S Parvez, et al. 2003 Aqueous extract of Walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity Hum Exp Toxicol 22 473 480 10.1191/0960327103ht388oa 1:STN:280:DC%2BD3srgt1GhtQ%3D%3D 14580007 (Pubitemid 37279290)
27. Hersh EM, Freireich EJ (1968) Host defense mechanisms and their modification by cancer chemotherapy. In: Busch H (ed) Methods in cancer research, vol 4. Academic Press, New York, pp 355-451
28. YT Hsu 1967 Study on the Chinese drugs used as a cancer remedy J South East Asian Res 3 63
29. AM Hutter AW Bauman IN Frank 1969 Cyclophosphamide and severe haemarragic cystitis N Y State J Med 69 305 309 5251301
30. SP Jain HS Puri 1984 Ethanomedicinal plants of Jaunsar-Bawar hills (Uttar Pradesh) India J Ethanopharmacol 12 213 222 10.1016/0378-8741(84)90049-7 1:STN:280:DyaL2M7gvFKnsw%3D%3D (Pubitemid 15186001)
31. Jakupovic J, Banerjee S, Castro V, Bohlmann F, Schuster A, Msonthi JD et al (1986) Poskeanolide, a seco-germacranolide and other sesquiterpene lactones from Vernonia species. Phytochemistry 25(6):1359
32. D John 1984 One hundred useful raw drugs of the Kani tribes of Trivandrum Int J Crude Drug Res 1 17 39
33. King JC (1965) The phosphorous. In: Van D (ed) Practical clinical enzymology. Nostrand, London, pp 191-208
34. G Krishna J Nath T Ong 1986 Inhibition of cyclophosphamide and mitomycin c-induced sister chromatid exchanges in mice by vitamin C Cancer Res 46 2670 2674 1:CAS:528:DyaL28Xkt1ensLk%3D 3084070
35. KBH Kumar R Kuttan 2005 Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice Phytomedicine 12 494 500 10.1016/j.phymed.2004.03.009 1:STN:280: DC%2BD2MzlsVOmuw%3D%3D 16008127 (Pubitemid 40755125)
36. Kumar V, Abbas AK, Fausto N (2004) Pathologic basis of diseases. Saunders publishers, Philadelphia, pp 828-830
37. Kuo Y-H, Kuo Y-J, Yu A-S, Wu M-D, Ong C-W, Yang Kuo L-M, Huang J-T, Chen C-F, Li S-Y (2003) Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull 51(4):425-426
38. RM Latha T Geetha P Varalakshmi 1998 Effect of Vernonia cinerea less flower extract in adjuvant induced arthritis Gen Pharmacol 31 601 606 10.1016/S0306-3623(98)00049-4 1:CAS:528:DyaK1cXlsFOks7s%3D 9792223 (Pubitemid 28458932)
39. S Mathew G Kuttan 1997 Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of CTX induced toxicity J Exp Clin Cancer Res 16 407 411 1:STN:280:DyaK1c7ms1WisA%3D%3D 9505214
40. TN Mishra RS Singh R Srivastava HS Pandey C Prasad S Singh 1993 A new triterpenoid from Vernonia cinerea Planta Med 59 5 458 10.1055/s-2006-959732 (Pubitemid 23319553)
41. MA Moron JW Depierre B Mannervick 1979 Levels of glutathione reductase and glutathione-S-transferase activities in rat liver Biochim Biophys Acta 582 67 68 1:CAS:528:DyaE1MXhtVSkurw%3D 760819
42. Murray RL (1984) Nonprotein compounds. In: Kaplan LA, Pesce AJ (eds) Clinical chemistry: theory, analysis and co-relation. Mosby C.V., Toranto, pp 1230-1268
43. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
44. HA Oketch-Rabah CS Brogger K Frydenvang SF Dossagi, et al. 1998 Antiprotozoal properties of 16, 17 dihydro-brachycalyoxide from Vernonia brachycalyx Planta Med 64 559 562 10.1055/s-2006-957514 1:CAS:528: DyaK1cXltlOqtbY%3D 9741304
45. K Praveen R Kuttan G Kuttan 1996 Radioprotective effect of Rasayanas Indian J Exp Biol 34 848 850
46. PS Rekha G Kuttan R Kuttan 2001 Effects of Brahma Rasayana on antioxidant systems and cytokine levels in mice during CTX administration J Exp Clin Cancer Res 20 219 223 1:STN:280:DC%2BD38%2FislCmtQ%3D%3D 11484978
47. M Samir NM el Kholy 1999 Thiobarbituric acid reactive substance in patients with laryngeal cancer Clin Otolaryngol 24 232 234 10.1046/j.1365-2273. 1999.00249.x 1:STN:280:DyaK1Mzht1yntA%3D%3D 10384852 (Pubitemid 29271848)
48. A Seven S Civelek E Inci N Korkut G Burcak 1999 Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma Clin Biochem 32 369 373 10.1016/S0009-9120(99)00022-3 1:STN:280:DyaK1MvgvVehuw%3D%3D 10480452 (Pubitemid 29416728)
49. VK Singh ZA Ali 1989 Folk medicines of Aligarh (Uttar Pradesh) India Fitoterapia LX 483 490
50. B Sredni M Albeck G Kazimirsky F Shalet 1992 Immunomodulator AS 101 administered orally as a chemoprotective and radioprotective agent Int J Immunopharmacol 14 613 619 10.1016/0192-0561(92)90122-2 1:CAS:528: DyaK38Xkt1amtrs%3D 1521929
51. J Theze PM Alzari J Bertoglio 1996 Interleukin 2 and its receptors: recent advances and new immunological functions Immunol Today 18 487 492
52. Toro G, Ackermann PG (1975) Practical clinical chemistry. Little Brown & Co., Boston, p 154
53. N Venkatesan G Chandrakasan 1995 Modulation of cyclophosphamide induced early lung injury by Curcumin, an anti-inflammatory antioxidant Mol Cell Biochem 142 79 87 10.1007/BF00928916 1:CAS:528:DyaK2MXksVKgsrc%3D 7753045
54. A Yokomizo K Kohno M Wada M Ono CS Morrow KH Cowan M Kuwano 1995 Markedly decreased expression of glutathione S-Transferase gene in gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis J Biol Chem 270 19451 19457 10.1074/jbc.270.33.19451 1:CAS:528:DyaK2MXnsFygsL4%3D 7642628