Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids

American Journal of Rhinology and Allergy

Volumn 24, Issue 4, 2010, Pages 286-290

  Sivam, Anita ^a   Jeswani, Seema ^a   Reder, Lindsay ^a   Wang, Jianghong ^a   DeTineo, Marcella ^a   Taxy, Jerome ^a   Baroody, Fuad M ^a   Naclerio, Robert M ^a   Pinto, Jayant M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Eosinophil; Human; Inflammation; Intranasal steroid; Quality of life; Randomized clinical trial; Seasonal allergic rhinitis

Indexed keywords

MOMETASONE FUROATE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOLOGY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDOSCOPIC BIOPSY; EOSINOPHIL; FEMALE; HAY FEVER; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MALE; OLFACTORY CLEFT INFLAMMATION; OLFACTORY EPITHELIUM; PEAK NASAL INSPIRATORY FLOW; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SMELLING; SMELLING DISORDER; TREATMENT DURATION; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ADULT; AGNOSIA; ALLERGENS; AMBROSIA; EOSINOPHILS; FEMALE; HUMANS; INFLAMMATION; INHALATION; MALE; MIDDLE AGED; NASAL CAVITY; OLFACTORY MUCOSA; POACEAE; POLLEN; PREGNADIENEDIOLS; QUALITY OF LIFE; RECOVERY OF FUNCTION; RHINITIS, ALLERGIC, SEASONAL;

EID: 77955591766     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2010.24.3478     Document Type: Article

References (28)

1. Passali GC, Ralli M, Galli J, et al. How relevant is the impairment of smell for the quality of life in allergic rhinitis? Curr Opin Allergy Clin Immunol 8:238-242, 2008.
2. Cowart BJ, Flynn-Rodden K, McGeady SJ, and Lowry LD. Hyposmia in allergic rhinitis. J Allergy Clin Immunol 91:747-751, 1993.
3. Seiden AM, Litwin A, and Smith DV. Olfactory deficits in allergic rhinitis. Chem Senses 14: 746-747, 1989.
4. Meltzer EO, Jalowayski AA, Orgel HA, and Harris AG. Subjective and objective assessments in patients with seasonal allergic rhinitis: Effects of therapy with mometasone furoate nasal spray. J Allergy Clin Immunol 102:39-49, 1998.
5. Moll B, Klimek L, Eggers G, and Mann W. Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis. Allergy 53:297-301, 1998.
6. Eccles R, Jawad MS, and Morris S. Olfactory and trigeminal thresholds and nasal resistance to airflow. Acta Otolaryngol 108:268-273, 1989.
7. Doty RL, and Frye R. Influence of nasal obstruction on smell function. Otolaryngol Clin North Am 22:397-411, 1989.
8. Kern RC. Chronic sinusitis and anosmia: Pathologic changes in the olfactory mucosa. Laryngoscope 110:1071-1077, 2000.
9. Goodspeed RB, Gent JF, Catalanotto FA, et al. Corticosteroids in olfactory dysfunction. In Clinical Measurement of Taste and Smell. Meiselman HL (Ed). New York: McMillan, 514-518, 1986.
10. Robinson AM, Kern RC, Foster JD, et al. Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa: Physiologic and pathophysiologic implications. Laryngoscope 108:1238-1242, 1998.
11. Jafek BW, Moran DT, Eller PM, et al. Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg 113:547-549, 1987.
12. Lin RY, Nahal A, Lee M, and Menikoff H. Cytologic distinctions between clinical groups using curette-probe compared to cytology brush. Ann Allergy Asthma Immunol 86:226-231, 2001.
13. Saengpanich S, deTineo M, Naclario RM, and Baroody FM. Fluticasone nasal spray and the combination of loratadine and montelukast in seasonal allergic rhinitis. Arch Otolaryngol Head Neck Surg 129:557-562, 2003.
14. Goldberg AN, Shea JA, Deems DA, and Doty RL. A ChemoSensory questionnaire for patients treated for cancer of the head and neck. Laryngoscope 115:2077-2086, 2005.
15. Doty RL, Shaman P, Kimmelman CP, and Dann MS. University of Pennsylvania Smell Identification Test: A rapid quantitative olfactory function test for the clinic. Laryngoscope 94:176-178, 1984. (Pubitemid 14186660)
16. Howarth PH, Persson CG, Meltzer EO, et al. Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol 115(suppl 1):S414-S441, 2005.
17. Leopold DA, Hummel T, Schwob JE, et al. Anterior distribution of human olfactory epithelium. Laryngoscope 110:417-421, 2000.
18. Davies RJ, and Nelson HS. Once-daily mometasone furoate nasal spray: Efficacy and safety of a new intranasal glucocorticoid for allergic rhinitis. Clin Ther 19:27-38, 1997.
19. Miwa T, Furukawa M, Tsukatani T, et al. Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg 127:497-503, 2001.
20. Douglass JA, Dhami D, Gurr CE, et al. Influence of interleukin-8 challenge in the nasal mucosa in atopic and nonatopic subjects. Am J Respir Crit Care Med 150:1108-1113, 1994.
21. Baroody FM, Gungor A, deTineo M, et al. Comparison of the response to histamine challenge of the nose and the maxillary sinus: Effect of loratadine. J Appl Physiol 87:1038-1047, 1999.
22. Baroody FM, Shenaq D, deTineo M, et al. Fluticasone furoate nasal spray reduces the nasal-ocular reflex: A mechanism for the efficacy of topical steroids in controlling allergic eye symptoms. J Allergy Clin Immunol 123:1342-1348, 2009. Epub May 2009.
23. deTineo ML, Clark K, Baroody FM, and Naclerio RM. Lack of evidence for muscarinic type 2 receptor modulation of the human nasonasal reflex. J Allergy Clin Immunol 107:194-195, 2001.
24. Mott AE, Cain WS, Lafreniere D, et al. Topical corticosteroid treatment of anosmia associated with nasal and sinus disease. Arch Otolaryngol Head Neck Surg 123:367-372, 1997.
25. Doty RL. Office procedures for quantitative assessment of olfactory function. Am J Rhinol 21:460-473, 2007.
26. Scheibe M, van Thriel C, and Hummel T. Responses to trigeminal irritants at different locations of the human nasal mucosa. Laryngoscope 118:152-155, 2008.
27. Klimek L, and Eggers G. Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation. J Allergy Clin Immunol 100:158-164, 1997.
28. Rombaux P, Mouraux A, Bertrand B, et al. Can we smell without an olfactory bulb? Am J Rhinol 21:548-550, 2007.