Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test

Psychopharmacology

Volumn 210, Issue 1, 2010, Pages 35-43

  Chaviaras, Stella ^a   Mak, Plato ^a   Ralph, David ^a   Krishnan, Lalitha ^a   Broadbear, Jillian H ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Antidepressant; Atosiban; Carbetocin; Desmopressin; Forced swim test; Imipramine; Oxytocin; Rat

Indexed keywords

AMPHETAMINE; ATOSIBAN; CARBETOCIN; DUROTOCIN; IMIPRAMINE; OXYTOCIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTIDEPRESSANT EFFECT; ARTICLE; CENTRAL NERVOUS SYSTEM; CLIMBING; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; FORCED SWIMMING TEST; IMMOBILIZATION; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; RECEPTOR UPREGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSION; IMIPRAMINE; IMMOBILIZATION; INJECTIONS, INTRAVENTRICULAR; MALE; MOTOR ACTIVITY; OXYTOCIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OXYTOCIN; SWIMMING;

EID: 77955578720     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1815-x     Document Type: Article

References (39)

1. Aghajanian GK (1985) Modulation of a transient outward current in serotonergic neurons by a1-adrenoceptors. Nature 315:501-503
2. Argiolas A, Gessa GL (1991) Central functions of oxytocin. Neurosci Biobehav Rev 15:217-231
3. Arletti R, Bertolini A (1987) Oxytocin acts as an antidepressant in two animal models of depression. Life Sci 41:1725-1530
4. Arletti R, Benelli A, Poggioli R, Luppi P, Menozzi B, Bertolini A (1995) Aged rats are still responsive to the antidepressant and memoryimproving effects of oxytocin. Neuropeptide 29:177-182
5. Bealer SL, Crowley WR (1998) Noradrenergic control of central oxytocin release during lactation in rats. Am J Physiol - Endocrinol Metab 274:453-458
6. Benoussaidh A, Maurin Y, Rampin O, (2005) Possible neuralmediation of the central effects of oxytocin on uterine motility. Am J Physiol - Reg Integ Comp Physiol 289:798-804
7. Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002a) Nonpeptidic ä-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology 26:744-755
8. Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002b) Convulsant activity of a non-peptidic d-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology 164:42-48
9. Chan WY, Wo NC, Stoev S, Cheng LL, Manning M (2000) Discovery and design of novel and selective vasopressin and oxytocin agonists and antagonists: the role of bioassays. Exp Physiol 85:7s-18s
10. Cunningham ET, Sawchenko PE (1988) Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 274:60-76
11. Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 121:66-72
12. Domes G, Heinrichs M, Gläscher J, Büchel C, Braus DF, Herpertz SC (2007) Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiat 62:1187-1190
13. Ebner K, Bosch OJ, Kromer SA, Singewald N, Neumann ID (2005) Release of oxytocin in the rat central amygdala modulates stresscoping behavior and the release of excitatory amino acids. Neuropsychopharmacology 30:223-230
14. Engstrom T, Barth T, Melin P, Vilhardt H (1998) Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation. Eur J Pharmacol 355:203-210
15. Gimpl G, Fahrenholz F (2001) The oxytocin receptor system: structure, function, and regulation. Physiological Rev 81:629-683
16. Gimpl G, Postina R, Fahrenholz F, Reinheimer T (2005) Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol 510:9-16
17. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiat 54:1389-1398
18. Jorgensen H, Riis M, Knigge U, Kjaer A, Warberg J (2003) Serotonin receptors involved in vasopressin and oxytocin secretion. J Neuroendocrinol 15:242-249
19. Klenerova V, Krejci I, Sida P, Hlinak Z, Hynie S (2009) Modulatory effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field. J Physiol Pharmacol 60:57-62
20. Landgraf R, Neumann ID (2004) Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol 25:150-176
21. Maas JW (1975) Biogenic amines and depression: biochemical and pharmacological separation of two types of depression. Arch Gen Psychiat 32:1357-1361
22. Manning M, Miteva K, Pancheva S, Stoev S, Wo NC, Chan WY (1995) Design and synthesis of highly selective in vitro and in vivo uterine receptor antagonists of oxytocin: comparisons with atosiban. Int J Pept Protein Res 46:244-252
23. Méchaly I, Laurent F, Portet K, Serrano JJ, Cros G (1999) Vasopressin V2 (SR121463A) and V1a (SR49059) receptor antagonists both inhibit desmopressin vasorelaxing activity. Eur J Pharmacol 383:287-290
24. Meisenberg G (1981) Short-term behavioral effects of posterior pituitary peptides in mice. Peptides 2:1-8
25. Meisenberg G (1982) Short-term behavioral effects of neurohypophyseal hormones: pharmacological characteristics. Neuropharmacology 21:309-316
26. Neumann ID (2008) Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J Neuroendocrinol 20:858-865
27. Nowakowska E, Kus K, Bobkiewicz-Kozlowska T, Hertmanowska H (2002) Role of neuropeptides in antidepressant and memory improving effects of venlafaxine. Pol J Pharmacol 54:605-613
28. Nutt DJ (2002) The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 17: S1-S12
29. Onaka T, Ikeda K, Yamashita T, Honda K (2003) Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus. Eur J NeuroSci 18:3018-3026
30. Pettibone DJ, Kishel MT, Woyden CJ, Clineschmidt BV, Bock MG, Freidinger RM, Veber DF, Williams PD (1992) Radioligand binding studies reveal marked species differences in the vasopressin V1 receptor of rat, rhesus and human tissues. Life Sci 50:1953-1958
31. Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379-391
32. Sala NL, Luther EC, Arballo JC, Cordero Funes JC (1974) Oxytocin reproducing reflex milk ejection in lactating women. J App Physiol 36:154-158
33. Sawchenko PE, Swanson LW, Steinbusch HWM, Verhofstad AAJ (1983) The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res 277:355-360
34. Scantamburlo G, Hansenne M, Fuchs S, Pitchot W, Maréchal P, Pequeux C, Ansseau M, Legros JJ (2007) Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology 32:407-410
35. Sofroniew MV (1980) Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human. J Histochem Cytochem 28:475-478
36. Uvnas-Moberg K, Bjorkstrand E, Hillegaart V, Ahlenius S (1999) Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology 142:95-101
37. Wong DT, Perry KW, Bymaster FP (2005) The discovery of fluoxetine hydrochloride (Prozac). Nature Rev Drug Discov 4:764-774
38. Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K (2009) Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci 29:2259-2271
39. Zetzsche T, Frasch A, Jirikowski G, Murck H, Steigner A (1996) Nocturnal oxytocin secretion is reduced in major depression. Biol Psychiat 39:584