Immunopathology and cytokine responses in commercial broiler chickens with gangrenous dermatitis

Avian Pathology

Volumn 39, Issue 4, 2010, Pages 255-264

  Li, Guangxing ^a,b   Lillehoj, Hyun S ^a   Lee, Kyung Woo ^a   Lee, Sung Hyen ^a   Park, Myeong Seon ^a   Jang, Seung I ^a   Bauchan, Gary R ^c   Gay, Cyril G ^c   Ritter, G Donald ^d   Bautista, Daniel A ^e   Siragusa, Gregory R ^f  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

^d MOUNTAIRE FARMS INC   (United States)

^e UNIVERSITY OF DELAWARE   (United States)

^f Agtech Products Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; MONOCLONAL ANTIBODY; NITRIC OXIDE; OROSOMUCOID; PRIMER DNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRD DISEASE; BLOOD; CELL PROLIFERATION; CHICKEN; CLOSTRIDIUM; COMPARATIVE STUDY; DERMATITIS; GANGRENE; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNITED STATES;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; CHEMOKINES; CHICKENS; CLOSTRIDIUM; CYTOKINES; DELAWARE; DERMATITIS; DNA PRIMERS; GANGRENE; HOST-PATHOGEN INTERACTIONS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; NITRIC OXIDE; OROSOMUCOID; POULTRY DISEASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

AVES; CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM SEPTICUM; GALLUS GALLUS;

EID: 77955577676     PISSN: 03079457     EISSN: 14653338     Source Type: Journal    
DOI: 10.1080/03079457.2010.495382     Document Type: Article

References (48)

1. Allen, P.C. (1997). Nitric oxide production during Eimeria tenella infections in chickens. Poultry Science, 76, 810-813.
2. Babu, U.S., Gaines, D.W., Lillehoj, H., & Raybourne, R.B. (2006). Differential reactive oxygen and nitrogen production and clearance of Salmonella serovars by chicken and mouse macrophages. Developelopmental and Comparative Immunology, 30, 942-953.
3. Bains, B.S., & MacKenzie, M.A. (1975). An outbreak of gangrenous dermatitis caused by Clostridium septicum in a broiler flock. Australian Veterinary Journal, 51, 106-107.
4. Bryant, A.E. & Stevens, D.L. (1997). The pathogenesis of gas gangrene. In J.I. Rood, B.A. McClane, J.G. Songer & R.W. Titball (Eds.). The Clostridia: Molecular Biology and Pathogenesis 1st edn (pp. 185-19). San Diego: Academic Press.
5. Bryant, A.E., Bergstrom, R., Zimmerman, G.A., Slyer, J.L., Hill, H.R., Sato, H., & Stevens, D.L. (1993). Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/ CD18 adherence glycoprotein. FEMS Immunology and Medical Microbiology, 7, 321-336.
6. Bueschel, D.M., Jost, B.H., Billington, S.J., Trinh, H.T., & Songer, J.G. (2003). Prevalence of cpb2, encoding beta 2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype. Veterinary Microbiology, 94, 121-129.
7. Chen, C.H., Ager, L.L., Gartland, G.L., & Cooper, M.D. (1986). Identification of a T3/T-cell receptor complex in chickens. Journal of Experimental Medicine, 164, 375-386.
8. Cheung, K.S., Lillehoj, H.S., & Jenkins, M.C. (1991). Avian leucocyte common antigens: molecular weight determination and flow cytometric analysis using new monoclonal antibodies. Veterinary Immunology and Immunopathology, 28, 259-273.
9. Cooper, K.K., & Songer, J.G. (2009). Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A. Anaerobe, 15, 55-60.
10. Fowler, N.G., & Hussaini, S.N. (1975). Clostridium septicum infection and antibiotic treatment in broiler chickens. The Veterinary Record, 96,14-15.
11. Gomis, S., Amoako, A.K., Ngeleka, A.M., Belanger, L., Althouse, B., Kumor, L., et al. (2002). Histopathologic and bacteriologic evaluations of cellulitis detected in legs and caudal abdominal regions of turkeys. Avian Diseases, 46, 192-197.
12. 15N]-nitrate in biological fluids. Analytical Biochemistry, 128, 131-138.
13. Hang'ombe, M.B., Mukamoto, M., Kohda, T., Sugimoto, N., & Kozaki, S. (2004). Cytotoxicity of Clostridium septicum alpha-toxin: its oligomerization in detergent resistant membranes of mammalian cells. Microbial Pathogenesis, 37, 279-286.
14. He, H., MacKinnon, K.M., Genovese, K.J., Nerren, J.R., Swaggerty, C.L., Nisbet, D.J., & Kogut, M.H. (2009). Chicken scavenger receptors and their ligand-induced cellular immune responses. Molecular Immunology, 46, 2218-2225.
15. Holtby, I., Tebbutt, G.M., Grant, K.A., McLauchlin, J., Kett, J., & Pinkney, S. (2008). A Clostridium perfringens food poisoning outbreak associated with consumption of chicken curry supplied by a home caterer. Public Health, 122, 1311-1314.
16. Hong, Y.H., Lillehoj, H.S., Lee, S.H., Park, D.W., & Lillehoj, E.P. (2006a). Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF). Developmental and Comparative Immunology, 30, 919-929.
17. Hong, Y.H., Lillehoj, H.S., Lillehoj, E.P., & Lee, S.H. (2006b). Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Veterinary Immunology and Immunopathology, 114, 259-272.
18. Jost, B.H., Billington, S.J., Trinh, H.T., Bueschel, D.M., & Songer, J.G. (2005). Atypical cpb2 genes, encoding beta2-toxin in Clostridium perfringens isolates of non-porcine origin. Infection and Immunity, 73, 652-656.
19. Juul-Madsen, H.R., Viertlboeck, B., Smith, A.L. & Göbel, T.W.F. (2008). Avian innate immune responses. In F. Davison, B. Kaspers, & K.A. Schat (Eds.). Avian Immunology 1st edn (pp. 129-158). London: Academic Press.
20. Karsten, H., Klaus, D.K., Christoph, V.S., & Victoria, K.B. (2005). What sense lies in antisense inhibition of inducible nitric oxide synthase expression? Nitric Oxide, 12, 183-199.
21. Kaspers, B., Lillehoj, H.S., & Lillehoj, E.P. (1993). Chicken macrophages and thrombocytes share a common cell surface antigen defined by a monoclonal antibody. Veterinary Immunology and Immunopathology, 36, 333-346.
22. Keyburn, A.L., Boyce, J.D., Vaz, P., Bannam, T.L., Ford, M.E., Parker, D., et al. (2008). NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathogen, 4, e26. doi:10.1371/journal.ppat.0040026.
23. Li, G., Lillehoj, H.S., Lee, K.W., Jang, S.I, Marc, P., Cyril, G., et al. (2010). An outbreak of gangrenous dermatitis in commercial broiler chickens. Avian Pathology, 39, 247-253.
24. Lillehoj, H.S., & Li, G. (2004). Nitric oxide production by macrophages stimulated with coccidia sporozoites, lipopolysaccharide, or interferon-g, and its dynamic changes in SC and TK strains of chickens infected with Eimeria tenella. Avian Diseases, 48, 244-253.
25. Lillehoj, H.S., Kim, S., Lillehoj, E.P., & Bacon, L.D. (1988b). Quantitative differences in Ia antigen expression in the spleens of 15I5-B congenic and inbred chickens as defined by a new monoclonal antibody. Poultry Science, 67, 1525-1535.
26. Lillehoj, H.S., Lillehoj, E.P., Weinstock, D., & Schat, K.A. (1988a). Functional and biochemical characterizations of avian T lymphocyte antigens identified by monoclonal antibodies. European Journal of Immunology, 18, 2059-2065.
27. MacMicking, J., Xie, Q.W., & Nathan, C. (1997). Nitric oxide and macrophage function. Annual Review of Immunology, 15, 323-530.
28. Martin, T.G., & Smyth, J.A. (2009). Prevalence of netB among some clinical isolates of Clostridium perfringens from animals in the United States. Veterinary Microbiology, 136, 202-205.
29. Mataragas, M., Skandamis, P.N., & Drosinos, E.H. (2008). Risk profiles of pork and poultry meat and risk ratings of various pathogen/ product combinations. International Journal of Food Microbiology, 126,1-12.
30. McDevitt, R.M., Brooker, J.D., Acamovic, T., & Sparks, N.H.C. (2006). Necrotic enteritis: a continuing challenge for the poultry industry. World's Poultry Science Journal, 62, 221-247.
31. Muller, P.Y., Janovjak, H., Miserez, A.R., & Dobbie, Z. (2002). Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques, 32, 1372-1379.
32. Neumann, A.P., & Rehberger, T.G. (2009). MLST analysis reveals a highly conserved core genome among poultry isolates of Clostridium septicum. Anaerobe, 15, 99-106.
33. Park, S.S., Lillehoj, H.S., Allen, P.C., Park, D.W., FitzCoy, S., Bautista, D.A., & Lillehoj, E.P. (2008). Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis. Avian Diseases, 52, 14-22.
34. Park, S.S., Lillehoj, H.S., Hong, Y.H., & Lee, S.H. (2007). Functional characterization of tumor necrosis factor superfamily 15 (TNFSF15) induced by lipopolysaccharides and Eimeria infection. Developmental and Comparative Immunology, 31, 934-944.
35. Pertile, T.L., Karaca, J.M., Sharma, J.M., & Walser, M.M. (1996). An antiviral effect of nitric oxide: inhibition of reovirus replication. Avian Diseases, 40, 342-348.
36. Pink, J.R.L., Kieran, M.W., Rijnbeek, A.M., & Longenecker, B.M. (1985). A monoclonal antibody against chicken MHC class I (B F) antigen. Immunogenetics, 21, 293-297.
37. Ritter, G.D. (2006). Proposed pathogenesis of gangrenous dermatitis in chickens and attempts at experimental reproduction. In Proceedings of the 41st National Meeting on Poultry Health and Processing (pp. 59-66). Ocean City, MD, USA.
38. Rothwell, C.J., Vervelde, L., & Davison, T.F. (1996). Identification of chicken Bu-1 alloantigens using the monoclonal antibody AV20. Veterinary Immunology and Immunopathology, 55, 225-234.
39. Rubbo, H., Radi, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., et al. (1994). Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Journal of Biological Chemistry, 269, 26066-26075.
40. Songer, J.G. (1996). Clostridial enteric disease of domestic animals. Clinical Microbiology Reviews, 9, 216-234.
41. Stuehr, D.J., & Nathan, C.F. (1989). Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cell. Journal of Experimental Medicine, 169, 1543-1555.
42. Tellez, G., Pumford, N.R., Morgan, M.J., Wolfenden, A.D., & Hargis, B.M. (2009). Evidence for Clostridium septicum as a primary cause of cellulitis in commercial turkeys. Journal of Veterinary Diagnostic Investigation, 21, 374-377.
43. Titball, R.W., Fearn, A.M., & Williamson, E.D. (1993). Biochemical and immunological properties of the C-terminal domain of the alpha-toxin of Clostridium perfringens. FEMS Microbiology Letters, 110,4550.
44. Tweten, R.K. (2001). Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenensis. Veterinary Microbiology, 82, 1-9.
45. Wages, D.P. & Opengart, K. (2003). Gangrenous dermatitis. In Y.M. Saif, H.J. Barnes, J.R. Glisson, A.M. Fadly, L.R. McDougald & D.E. Swayne (Eds.). Diseases of Poultry 11th edn (pp. 791-795). Ames: Iowa State Press.
46. Williams, R.B. (2005). Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian Pathology, 34, 159-180.
47. Willoughby, D.H., Bickford, A.A., Cooper, G.L., & Charlton, B.R. (1996). Periodic recurrence of gangrenous dermatitis associated with Clostridium septicum in a broiler chicken operation. Journal of Veterinary Diagnostic Investigation, 8, 259-261.
48. Withanage, G.S.K., Sasai, K., Fukata, T., Miyamoto, T., Lillehoj, H.S., & Baba, E. (2003). Increased lymphocyte subpopulations and macrophages in the ovaries and oviducts of laying hens infected with Salmonella enterica serovar Enteritidis. Avian Pathology, 32, 583-590.