Conditioned fear in adult rats is facilitated by the prior acquisition of a classically conditioned motor response

Neurobiology of Learning and Memory

Volumn 94, Issue 2, 2010, Pages 167-175

  Lindquist, Derick H ^a   Mahoney, Luke P ^b   Steinmetz, Joseph E ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Eyeblink conditioning; Fear conditioning; Freezing; Pavlovian conditioning; Rat; Two process model

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; EYELID REFLEX; FEAR; LEARNING; MALE; MOTOR PERFORMANCE; NONHUMAN; RAT; STIMULUS RESPONSE;

EID: 77955566021     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nlm.2010.05.003     Document Type: Article

References (37)

1. Blanchard R.J., Blanchard D.C. Crouching as an index of fear. Journal of Comparative and Physiological Psychology 1969, 67(3):370-375.
2. Bolles R.C., Collier A.C. The effect of predictive cues on freezing in rats. Animal Learning & Behavior 1976, 4:6-8.
3. Britton G.B., Astheimer L.B. Fear develops to the conditioned stimulus and to the context during classical eyeblink conditioning in rats. Integrative Physiological & Behavioral Science 2004, 39(4):295-306.
4. Chachich M., Powell D.A. Both medial prefrontal and amygdala central nucleus lesions abolish heart rate classical conditioning, but only prefrontal lesions impair reversal of eyeblink differential conditioning. Neuroscience Letters 1998, 257:151-154.
5. Christian K.M., Thompson R.F. Neural substrates of eyeblink conditioning: Acquisition and retention. Learning and Memory 2003, 11:427-455.
6. Corcoran K.A., Quirk G.J. Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. The Journal of Neuroscience 2007, 27(4):840-844.
7. Fanselow M.S. Conditional and unconditional components of post-shock freezing. Pavlovian Journal of Biological Science 1980, 15:177-182.
8. Halverson H.E., Freeman J.H. Medial auditory thalamic nuclei are necessary for eyeblink conditioning. Behavioral Neuroscience 2006, 120(4):880-887.
9. Halverson H.E., Poremba A., Freeman J.H. Medial auditory thalamus inactivation prevents acquisition and retention of eyeblink conditioning. Learning & Memory 2008, 15(7):532-538.
10. Hopkins D.A., Holstege G. Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat. Experimental Brain Research 1978, 32:529-547.
11. Kim J.J., Fanselow M.S. Modality-specific retrograde amnesia of fear. Science 1992, 256:675-677.
12. Konorski, J. (1967). Integrative activity of the brain. Chicago: University of Chicago.
13. Lavond D.G., Lincoln J.S., McCormick D.A., Thompson R.F. Effect of bilateral lesions of the dentate and interpositus cerebellar nuclei on conditioning of heart-rate and nictitating membrane/eyelid responses in the rabbit. Brain Research 1984, 305:323-330.
14. LeDoux J.E. Emotion circuits in the brain. Annual Review of Neuroscience 2000, 23:155-184.
15. LeDoux J.E., Iwata J., Cicchetti P., Reis D.J. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. The Journal of Neuroscience 1988, 8(7):2517-2529.
16. Lee T., Kim J.J. Differential effects of cerebellar, amygdalar, and hippocampal lesions on classical eyeblink conditioning in rats. The Journal of Neuroscience 2004, 24(13):3242-3250.
17. Lennartz R.C., Weinberger N.M. Analysis of response systems in Pavlovian conditioning reveals rapidly versus slowly acquired conditioned responses: Support for two factors, implications for behavior and neurobiology. Psychobiology 1992, 20(2):93-119.
18. Lindquist D.H., Brown T.H. Amygdalar NMDA receptors control the expression of associative reflex facilitation and three other conditional responses. Behavioral Neuroscience 2004, 118(1):36-52.
19. Mackintosh N.J. Conditioning and associative learning 1983, Oxford University Press, New York.
20. Maren S., Fanselow M.S. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. The Journal of Neuroscience 1995, 15:7548-7564.
21. McDonald A.J. Cortical pathways to the mammalian amygdala. Progress in Neurobiology 1998, 55:257-332.
22. Mintz M., Wang-Ninio Y. Two-stage theory of conditioning: Involvement of the cerebellum and the amygdala. Brain Research 2001, 897:150-156.
23. Mowrer O.H. On the dual nature of learning - A reinterpretation of "conditioning" and "problem-solving" Harvard Educational Review 1947, 17:102-148.
24. Nader K., Majidishad P., Amorapanth P., LeDoux J.E. Damage to the lateral, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learning & Memory 2001, 8:156-163.
25. Paré D., Quirk G.J., LeDoux J.E. New vistas on amygdala networks in conditioned fear. Journal of Neurophysiology 2004, 92:1-9.
26. Pitkanen A., Pikkarainen M., Nurminen N., Ylinen A. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. Annals of the New York Academy of Sciences 2000, 911:369-391.
27. Prokasy, W. F. (1972). Developments with the two-phase model applied to human eyelid conditioning. In A. H. Black & W. F. Prokasy (Eds.), Classical conditioning II: Current research and theory (pp. 199-247). New York: Appleton-Century-Crofts.
28. Quirk G.J., Armony J.L., LeDoux J.E. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala. Neuron 1997, 19:613-624.
29. Quirk G.J., Repa C., LeDoux J.E. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat. Neuron 1995, 15(5):1029-1039.
30. Rescorla R.A., Solomon R.L. Two-process learning theory: Relationships between Pavlovian conditioning and instrumental learning. Psychological Review 1967, 74(3):151-182.
31. Romanski L.M., LeDoux J.E., Clugnet M.C., Bordi F. Somatosensory and auditory convergence in the lateral nucleus of the amygdala. Behavioral Neuroscience 1993, 107:444-450.
32. Rorick-Kehn L.M., Steinmetz J.E. Amygdalar unit activity during three learning tasks: Eyeblink classical conditioning, Pavlovian fear conditioning, and signaled avoidance conditioning. Behavioral Neuroscience 2005, 119(5):1254-1276.
33. Schneiderman N., Smith M.C., Smith A.C., Gormezano I. Heart rate classical conditioning in rabbits. Psychological Science 1966, 6:241-242.
34. Thompson R.F., Donegan N.H., Clark G.A., Lavond D.G., Lincoln J.S., Madden J., et al. Neuronal substrates of discrete, defensive conditioned reflexes, conditioned fear states, and their interactions in the rabbit. Classical conditioning 1987, 371-399. Erlbaum, Hillsdale, NJ. 3rd ed. I. Gormezano, W.F. Prokasy, R.F. Thompson (Eds.).
35. Wagner A.R., Brandon S.E. Evolution of a structured connectionist model of Pavlovian conditioning (AESOP). Contemporary learning theories: Pavlovian conditioning and the status of traditional learning theory 1989, 149-190. Erlbaum, Hillsdale, NJ. S.B. Klein, R.R. Mowrer (Eds.).
36. Weisz D.J., Harden D.G., Xiang Z. Effects of amygdala lesions on reflex facilitation and conditioned response acquisition during nictitating membrane response conditioning in rabbit. Behavioral Neuroscience 1992, 106(2):262-273.
37. Wilensky A.E., Schafe G.E., Kristensen M.P., LeDoux J.E. Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. The Journal of Neuroscience 2006, 26(48):12387-12396.