Quantitative differences in intervertebral disc-matrix composition with age-related degeneration

Medical and Biological Engineering and Computing

Volumn 48, Issue 5, 2010, Pages 469-474

  Murakami, Hideki ^a,b,c   Yoon, Tim S ^b,c   Attallah Wasif, Emad S ^b,c   Kraiwattanapong, Chaiwat ^b,c   Kikkawa, Ichiro ^b,c   Hutton, William C ^b,c,d  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Emory Spine Center   (United States)

Author keywords

Age; Aggrecan; DNA; Intervertebral disc; Real time PCR; SGAG; Type I collagen; Type II collagen; Water content

Indexed keywords

INTERVERTEBRAL DISCS; REAL-TIME PCR; SGAG; TYPE I COLLAGEN; TYPE II COLLAGENS;

COLLAGEN; DNA; GENES;

WATER CONTENT;

COLLAGEN; DNA; MESSENGER RNA; PROTEOGLYCAN;

AGING; ANIMAL; ARTICLE; BODY WATER; GENETICS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRA; METABOLISM; RABBIT;

AGING; ANIMALS; BODY WATER; COLLAGEN; DNA; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRAE; PROTEOGLYCANS; RABBITS; RNA, MESSENGER;

EID: 77955565863     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11517-010-0586-1     Document Type: Article

References (19)

1. Antoniou J, Steffen T, Nelson F et al (1996) The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 98:996-1003 (Pubitemid 26293318)
2. Antoniou J, Pike GB, Steffen T et al (1998) Quantitative magnetic resonance imaging in the assessment of degenerative disc disease. Magn Reson Med 40:900-907
3. Antoniou J, Demers CN, Beaudoin G et al (2004) Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn Reson Imaging 22:963-972
4. Boos N, Weissbach S, Rohrbach H et al (2002) Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in Basic Science. Spine 27:2631-2644
5. Buckwalter JA (1995) Aging and degeneration of the human intervertebral disc. Spine 20:1307-1314
6. Chandrasekhar S, Esterman MA, Hoffman HA (1987) Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem 161:103-108
7. Cs-Szabo G, Ragasa-San Juan D, Turumella V et al (2002) Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 27:2212-2219
8. Ghosh P, Bushell GR, Taylor TF et al. (1977) Collagens, elastin and noncollagenous protein of the intervertebral disk. Clin Orthop (129):124-132
9. Gruber HE, Hanley EN Jr (1998) Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine 23:751-757
10. Hadjipavlou AG, Simmons JW, Yang JP et al (1998) Torsional injury resulting in disc degeneration. I. An in vivo rabbit model. J Spinal Disord 11:312-317
11. Kim YJ, Sah RL, Doong JY et al (1988) Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-176
12. Lipson SJ, Muir H (1981) 1980 Volvo award in basic science. Proteoglycans in experimental intervertebral disc degeneration. Spine 6:194-210
13. Natarajan RN, Ke JH, Andersson GB (1994) A model to study the disc degeneration process. Spine 19:259-265
14. Nerlich AG, Boos N, Wiest I et al (1998) Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages. Virchows Arch 432:67-76
15. Neufeld JH, Machado T, Margolin L (1991) Variables affecting disc size in the lumbar spine of rabbits: anesthesia, paralysis, and disc injury. J Orthop Res 9:104-112
16. Pedrini-Mille A et al (1990) Stimulation of dorsal root ganglia and degradation of rabbit annulus fibrosus. Spine 15:1252-1256
17. Roberts S, Menage J, Duance V et al (1991) 1991 Volvo Award in basic sciences. Collagen types around the cells of the intervertebral disc and cartilage end plate: an immunolocalization study. Spine 16:1030-1038
18. Singh K, Masuda K, Eugene JM, Thonar A, An HS (2008) Agerelated changes in extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine 34 (1):10-16
19. Sowa G, Vadala G, Studer R et al (2008) Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology and gene expression. Spine 33 (17):1821-1828