Multidimensional statistical analysis of PTR-MS breath samples: A test study on irradiation detection

International Journal of Mass Spectrometry

Volumn 295, Issue 1-2, 2010, Pages 13-20

  Fedrigo, Mattia ^a   Hoeschen, Christoph ^a   Oeh, Uwe ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Breath gas VOC; Detection of exposure; Multidimensional analysis; PTR MS

Indexed keywords

EID: 77955565093     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2010.06.011     Document Type: Article

References (26)

1. Risby T.H., Solga S.F. Current status of clinical breath analysis. Applied Physics B: Lasers and Optics 2006, 85:421-426.
2. Miekisch W., Schubert J.K., Noeldge-Schomburg G.F.E. Diagnostic potential of breath analysis-focus on volatile organic compounds. Clinica Chimica Acta 2004, 347:25-39.
3. Amann A., Poupart G., Telser S., Ledochowski M., Schmid A., Mechtcheriakov S. Applications of breath gas analysis in medicine. International Journal of Mass Spectrometry 2004, 239:227-233.
4. Hansel A., Jordan A., Holzinger R., Prazeller P., Vogel W., Lindinger W. Proton transfer reaction mass spectrometry: on-line trace gas analysis at ppb level. International Journal of Mass Spectrometry and Ion Processes 1995, 149/150:609-619.
5. Lindinger W., Hansel A., Jordan A. Proton-transfer reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at pptv levels. Chemical Society Reviews 1998, 27:347-354.
6. A. Hansel, T.D. Märk (Eds.), International Journal of Mass Spectrometry, Special Issue on Proton Transfer Reaction Mass Spectrometry Volume 239, Issues 2-3 (2004).
7. Jordan A., Hansel A., Holzinger R., Lindinger W. Acetonitrile and benzene in the breath of smokers and non-smokers investigated by proton transfer reaction mass spectrometry (PTR-MS). International Journal of Mass Spectrometry and Ion Processes 1995, 148:L1-L3.
8. Taucher J. Investigation of Volatile Organic Compounds in Human Breath Using Proton Transfer Reaction Mass Spectrometry 1996, Institute of Ion Physics and Applied Physics Innsbruck, Innsbruck, (in German).
9. Taucher J., Hansel A., Jordan A., Fall R., Futrell J.H., Lindinger W. Detection of isoprene in expired air from human subjects using proton-transfer-reaction mass spectrometry. Rapid Communications in Mass Spectrometry 1997, 11:1230-1234.
10. Karl T., Prazeller P., Mayr D., Jordan A., Rieder J., Fall R., Lindinger W. Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. Journal of Applied Physiology 2001, 91:762.
11. Lindinger W., Taucher J., Jordan A., Hansel A., Vogel W. Endogenous production of methanol after the consumption of fruit. Alcoholism: Clinical and Experimental Research 1997, 21:939.
12. Moser B., Bodrogi F., Eibl G., Lechner M., Rieder J., Lirk P. Mass spectrometric profile of exhaled breath-field study by PTR-MS. Respiratory Physiology and Neurobiology 2005, 145:295.
13. Lirk P., Bodrogi F., Rieder J. Medical applications of proton transfer reaction-mass spectrometry: ambient air monitoring and breath analysis. International Journal of Mass Spectrometry 2004, 239:221.
14. Wehinger A., Schmid A., Mechtcheriakov S., Ledochowski M., Grabmer C., Gastl G.A., Amann A. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas. International Journal of Mass Spectrometry 2007, 265:49.
15. Greiter Matthias: Atemluftanalyse mittels Protonen Transfer Reaktions Massenspektrometrie (PTR-MS) 2003, TU München.
16. Sadrozinski H.F.-W. Radiation effects in life sciences. Nuclear Instruments and Methods in Physics Research 2003, A514:224-229.
17. Little J.B. Non-targeted effects of ionizing radiation: implications for radiation protection. Proceedings of 11th International Congress of the International Radiation Protection Association, IRPA 11 2004.
18. Prise K.M., Schettino G., Folkard M., Held K.D. New insights on cell death from radiation exposure. Lancet Oncology 2005, 6(July (7)):520-528.
19. Anderson J.C., Babb A.L., Hlastala M.P. Modeling soluble gas exchange in the airways and alveoli. Annals of Biomedical Engineering 2003, 31:1402-1422.
20. Skeldon K.D., Patterson C., Wyse C.A., Gibson G.M., Padgett M.J., Longbottom C., McMillan L.C. The potential offered by real-time, high-sensitivity monitoring of ethane in breath and some pilot studies using optical spectroscopy. Journal of Optics A: Pure and Applied Optics 2005, 7:376-384.
21. Keck L., Oeh U., Hoeschen C. Effects of carbon dioxide in breath gas on proton transfer reaction-mass spectrometry (PTR-MS) measurements. International Journal of Mass Spectrometry 2008, 270:156-165.
22. Taucher J., Lagg A., Hansel A., Vogel W., Lindinger W. Methanol in human breath. Alcoholism: Clinical and Experimental Research 1995, 19:1147-1150.
23. P. Atkins, J. de Paula, Physical Chemistry, 8th edition, Oxford University Press (2006).
24. S. Ross, Introduction to Probability and Statistics for Engineers and Scientists, 3rd edition, Elsevier (2004).
25. Amann A., Telser S., Hofer L., Schmod A., Hinterhuner H. Breath gas as biochemical probe in sleeping individuals. 2nd International Conference on Proton transfer Reaction Mass Spectrometry and its Applications 2005, Innsbruck University Press, Obergurgl. A. Hansel, T.D. Märk (Eds.).
26. Turner C., Spanel P., Smith D. A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS). Physiological Measurement 2006, 27:13-22.