An automated algorithm for sequence confirmation of chemically modified oligonucleotides by tandem mass spectrometry

Analytical Biochemistry

Volumn 405, Issue 2, 2010, Pages 213-223

  Kretschmer, Matthias ^a   Lavine, Gary ^a   McArdle, James ^b   Kuchimanchi, Satya ^a   Murugaiah, Veeravagu ^a   Manoharan, Muthiah ^a  

^a ALNYLAM PHARMACEUTICALS   (United States)

^b McArdle and Associates   (United States)

Author keywords

Data analysis software; Ion pair reversed phase HPLC; MS MS; Oligonucleotide; Sequence confirmation; SiRNA

Indexed keywords

DATA HANDLING; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFORMATION ANALYSIS; MASS SPECTROMETRY; OLIGONUCLEOTIDES; SYNTHESIS (CHEMICAL); TESTING;

DATA ANALYSIS SOFTWARES; MS/MS; REVERSED PHASE HPLC; SEQUENCE CONFIRMATION; SIRNA;

DRUG PRODUCTS;

ANTISENSE OLIGONUCLEOTIDE; DOUBLE STRANDED RNA; MESSENGER RNA; NUCLEOSIDE; OLIGONUCLEOTIDE; SMALL INTERFERING RNA;

ALGORITHM; ARTICLE; AUTOMATION; ELECTROSPRAY MASS SPECTROMETRY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA ANALYSIS; RNA INTERFERENCE; RNA SYNTHESIS; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 77955561446     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.06.023     Document Type: Article

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