Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes

Archives of Dermatological Research

Volumn 302, Issue 6, 2010, Pages 429-433

  Lee, Weon Ju ^a   Jung, Hong Dae ^a   Chi, Seong Geun ^a   Kim, Byung Soo ^a   Lee, Seok Jong ^a   Kim, Do Won ^a   Kim, Moon Kyu ^a   Kim, Jung Chul ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Acne; Cultured sebocyte; Dihydrotestosterone; Inflammatory cytokines

Indexed keywords

ANDROSTANOLONE; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; RNA; TUMOR NECROSIS FACTOR ALPHA;

ACNE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; GENE AMPLIFICATION; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEBACEOUS CELL; SEBUM SECRETION; SKIN CELL; UPREGULATION;

ACNE VULGARIS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DIHYDROTESTOSTERONE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; KERATINOCYTES; ORGAN CULTURE TECHNIQUES; SEBACEOUS GLANDS; SEBUM; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 77955559439     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-009-1019-6     Document Type: Article

References (21)

1. H Akamatsu CC Zouboulis CE Orfanos 1992 Control of human sebocyte proliferation in vitro by testosterone and 5-α-dihydrotestosterone is dependent on the localization of the sebaceous glands J Invest Dermatol 99 509 511 10.1111/1523-1747.ep12616181 1:CAS:528:DyaK3sXlt1Kguw%3D%3D 1402009
2. R Choudhry MB Hodgins TH Van der Kwast AO Brinkmann WJ Boersma 1992 Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands J Endocrinol 133 467 475 10.1677/joe.0.1330467 1:CAS:528: DyaK38XisVyrs7g%3D 1613448
3. Cunliffe WJ (1989) Acne. Martin Dunitz, London
4. T Fujie T Shikiji N Uchida Y Urano H Nagae S Arase 1996 Culture of cells derived from the human sebaceous glands under serum-free conditions without a biological feeder layer or specific matrices Arch Dermatol Res 288 703 708 10.1007/BF02505281 1:CAS:528:DyaK28XnsFemtLc%3D 8931874
5. RJ Gonzales SP Duckles DN Krause 2009 Dihydrotestosterone stimulates cerebrovascular inflammation through NFκB, modulating contractile function J Cereb Blood Flow Metab 28 244 253 10.1038/jcbfm.2008.115
6. R Guy MR Green T Kealey 1996 Modeling acne in vitro J Invest Dermatol 106 176 182 10.1111/1523-1747.ep12329907 1:STN:280:DyaK287lsVSktQ%3D%3D 8592071
7. A Köch T Schwarz R Kirnbauer A Urbanski P Perry JC Ansel, et al. 1990 Human keratinocytes are a source for tumor necrosis factor α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light J Exp Med 172 1609 1614 10.1084/jem.172.6.1609
8. WJ Lee HD Jung HJ Lee BS Kim SJ Lee DW Kim 2008 Influence of substance-P on cultured sebocytes Arch Dermatol Res 300 311 316 10.1007/s00403-008-0854-1 1:CAS:528:DC%2BD1cXotVyls78%3D 18427822
9. TA Luger T Schwarz 1990 Evidence for an epidermal cytokine network J Invest Dermatol 95 1005 1011 10.1111/1523-1747.ep12874944
10. MG Mercurio DS Gogstetter 2000 Androgen physiology and the cutaneous pilosebaceous unit J Gend Specif Med 3 59 64 1:STN:280:DC%2BD3Mzgt1Wrsg%3D%3D 11253232
11. Nelson AM, Thiboutot DM (2008) Biology of sebaceous glands. In: Wolff K et al (eds) Fitzpatrick's dermatology in general medicine, 7th edn. McGraw-Hill, New York, pp 687-690
12. M Partridge D Chantry M Turner M Feldmann 1991 Production of IL-1 and and IL-6 by human keratinocytes and squamous cell carcinoma cell lines J Invest Dermatol 96 771 776 10.1111/1523-1747.ep12471723 1:CAS:528:DyaK3MXksVOmtrc%3D 2022885
13. G Sansone RM Reiser 1971 Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin-a possible pathogenic factor in acne J Invest Dermatol 56 366 372 10.1111/1523-1747.ep12261252 1:CAS:528:DyaE3MXktVartb8%3D 4253995
14. KH Singer DT Tuck HA Sampson RP Hall 1989 Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses J Invest Dermatol 93 746 750 10.1111/1523-1747.ep12722441
15. JS Strauss AM Kligman PE Pochi 1962 The effect of androgens and estrogens on human sebaceous glands J Invest Dermatol 39 139 155 1:CAS:528: DyaF3sXktFensg%3D%3D 13917704
16. GF Webster 2005 The pathophysiology of acne Cutis 76 4 7 16164150
17. MH Winston AR Shalita 1991 Acne vulgaris. Pathogenesis and treatment Pediatr Clin North Am 38 889 903 1:STN:280:DyaK3MzjsVShsA%3D%3D 1831256
18. CC Zouboulis 2004 Acne and sebaceous gland function Clin Dermatol 22 360 366 10.1016/j.clindermatol.2004.03.004 15556719 (Pubitemid 39535276)
19. CC Zouboulis WC Chen MJ Thornton K Qin R Rosenfield 2007 Sexual hormones in human skin Horm Metab Res 39 85 95 10.1055/s-2007-961807 1:CAS:528: DC%2BD2sXltF2is74%3D 17326004 (Pubitemid 46540281)
20. CC Zouboulis L Xia H Akamatsu H Seltmann M Fritsch S Hornemann, et al. 1998 The human sebocyte culture model provides new insights into development and management of seborrhea and acne Dermatology 196 21 31 10.1159/000017861 1:STN:280:DyaK1c3hsl2ksQ%3D%3D 9557220 (Pubitemid 28116033)
21. CC Zouboulis L Xia M Detmar B Bogdanoff G Giannakopoulos H Gollnick, et al. 1991 Culture of human sebocytes and markers of sebocytic differentiation in vitro Skin Pharmacol 4 74 83 10.1159/000210927 1:STN:280:DyaK3MzksF2huw%3D%3D 1715175