Wingless-type MMTV integration site family (WNT) signalling in pancreatic beta cells-more complex than expected

Diabetologia

Volumn 53, Issue 9, 2010, Pages 2073-2075

  Schinner, S ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Diabetes mellitus; Islet; TCF7L2; WNT signalling

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; WNT PROTEIN; WNT4 PROTEIN; T CELL FACTOR PROTEIN;

CANONICAL ANALYSIS; CELL NUCLEUS TRANSPLANTATION; CYTOLOGY; GENE EXPRESSION REGULATION; HUMAN; LETTER; METABOLIC REGULATION; NONHUMAN; PANCREAS ISLET BETA CELL; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; INSULIN-SECRETING CELLS; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 77955554379     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1814-9     Document Type: Letter

References (11)

1. V Lyssenko R Lupi P Marchetti, et al. 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes J Clin Invest 117 2155 2163 10.1172/JCI30706 1:CAS:528:DC%2BD2sXoslOnsrk%3D 17671651 (Pubitemid 47219560)
2. S Schinner HS Willenberg M Schott WA Scherbaum 2009 Pathophysiological aspects of Wnt-signaling in endocrine disease Eur J Endocrinol 160 731 737 10.1530/EJE-08-0831 1:CAS:528:DC%2BC3cXit1Cn 19246555
3. S Schinner F Ulgen C Papewalis, et al. 2008 Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules Diabetologia 51 147 154 10.1007/s00125-007-0848-0 1:STN:280:DC%2BD2sjgvFCktA%3D%3D 17994217 (Pubitemid 50002200)
4. IC Rulifson SK Karnik PW Heiser, et al. 2007 Wnt signaling regulates pancreatic beta cell proliferation Proc Natl Acad Sci USA 104 6247 6252 10.1073/pnas.0701509104 1:CAS:528:DC%2BD2sXks1arurk%3D 17404238 (Pubitemid 47186080)
5. J Krützfeldt M Stoffel 2010 Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice Diabetologia 53 123 127 10.1007/s00125-009-1578-2 19898815
6. T Fujino H Asaba MJ Kang, et al. 2003 Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion Proc Natl Acad Sci USA 100 229 234 10.1073/pnas.0133792100 1:CAS:528:DC%2BD3sXktlOnsQ%3D%3D 12509515 (Pubitemid 36078057)
7. L Shu NS Sauter FT Schulthess AV Matveyenko J Oberholzer K Maedler 2008 Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets Diabetes 57 645 653 10.2337/db07-0847 1:CAS:528: DC%2BD1cXjt1Chtbo%3D 18071026
8. LC Murtaugh 2008 The what, where, when and how of Wnt/beta-catenin signaling in pancreas development Organogenesis 4 81 86 10.4161/org.4.2.5853 18953422
9. R van Amerongen R Nusse 2009 Towards an integrated view of Wnt signaling in development Development 136 3205 3214 10.1242/dev.033910 19736321
10. B Gustafson B Eliasson U Smith 2010 Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis Diabetologia 53 536 540 10.1007/s00125-009-1615-1 1:CAS:528:DC%2BC3cXhsVygtrw%3D 19943155
11. P Bernard A Fleming A Lacombe VR Harley E Vilain 2008 Wnt4 inhibits beta-catenin/TCF signalling by redirecting beta-catenin to the cell membrane Biol Cell 100 167 177 10.1042/BC20070072 1:CAS:528:DC%2BD1cXitVKqtrw%3D 17976036 (Pubitemid 351372675)