-
1
-
-
0022003367
-
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
-
Seto S, Carrera CJ, Kubota M, Wasson DB, Carson DA. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest. 1985; 75(2):37-83.
-
(1985)
J Clin Invest
, vol.75
, Issue.2
, pp. 37-83
-
-
Seto, S.1
Carrera, C.J.2
Kubota, M.3
Wasson, D.B.4
Carson, D.A.5
-
2
-
-
68049128257
-
Cladribine: Not just another purine analogue?
-
Spurgeon S, Yu M, Phillips JD, Epner EM. Cladribine: Not just another purine analogue? Expert Opin Investig Drugs. 2009;18(8): 1169-1181.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.8
, pp. 1169-1181
-
-
Spurgeon, S.1
Yu, M.2
Phillips, J.D.3
Epner, E.M.4
-
3
-
-
0029983154
-
The treatment of chronic progressive multiple sclerosis with cladribine
-
Beutler E, Sipe JC, Romine JS, Koziol JA, McMillan R, Zyroff J. The treatment of chronic progressive multiple sclerosis with cladribine. Proc Natl Acad Sci U S A. 1996;93(4):1716-1720.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.4
, pp. 1716-1720
-
-
Beutler, E.1
Sipe, J.C.2
Romine, J.S.3
Koziol, J.A.4
McMillan, R.5
Zyroff, J.6
-
4
-
-
0034646216
-
Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group
-
Rice GP, Filippi M, Comi G. Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology. 2000;54(5):1145-1155.
-
(2000)
Neurology
, vol.54
, Issue.5
, pp. 1145-1155
-
-
Rice, G.P.1
Filippi, M.2
Comi, G.3
-
5
-
-
0032908474
-
A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
-
Romine JS, Sipe JC, Koziol JA, Zyroff J, Beutler E. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc Assoc Am Physicians. 1999;111(1):35-44.
-
(1999)
Proc Assoc Am Physicians
, vol.111
, Issue.1
, pp. 35-44
-
-
Romine, J.S.1
Sipe, J.C.2
Koziol, J.A.3
Zyroff, J.4
Beutler, E.5
-
6
-
-
77955545083
-
-
NCT00213135
-
Serono E. CLARITY: A Phase III, randomized, double-blind, threearm, placebo-controlled, multi-center study to evaluate the safety and efficacy of oral cladribine in subjects with relapsing-remitting multiple sclerosis. NCT00213135.
-
CLARITY: A Phase III, Randomized, Double-blind, Threearm, Placebo-controlled, Multi-center Study to Evaluate the Safety and Efficacy of Oral Cladribine In Subjects With Relapsing-remitting Multiple Sclerosis
-
-
Serono, E.1
-
7
-
-
54949143968
-
Alemtuzumab vs interferon beta-1a in early multiple sclerosis
-
Coles AJ, Compston DA, Selmaj KW, et al. Alemtuzumab vs interferon beta-1a in early multiple sclerosis. N Engl J Med. 2008;359(17): 1786-1801.
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1786-1801
-
-
Coles, A.J.1
Compston, D.A.2
Selmaj, K.W.3
-
8
-
-
39049142995
-
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
-
Hauser SL, Waubant E, Arnold DL, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med. 2008;358(7):676-688.
-
(2008)
N Engl J Med
, vol.358
, Issue.7
, pp. 676-688
-
-
Hauser, S.L.1
Waubant, E.2
Arnold, D.L.3
-
9
-
-
70449418132
-
Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial
-
Hawker K, O'Connor P, Freedman MS, et al. Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol. 2009;66(4):460-471.
-
(2009)
Ann Neurol
, vol.66
, Issue.4
, pp. 460-471
-
-
Hawker, K.1
O'Connor, P.2
Freedman, M.S.3
-
10
-
-
77955522909
-
-
NCT00676715
-
Genentech HLR. Phase II, multicenter, randomized, parallel-group, partially blinded, placebo and Avonex controlled dose finding study to evaluate the efficacy as measured by brain MRI lesions, and safety of 2 dose regimens of ocrelizumab in patients with RRMS. NCT00676715.
-
Phase II, Multicenter, Randomized, Parallel-group, Partially Blinded, Placebo and Avonex Controlled Dose Finding Study to Evaluate the Efficacy As Measured By Brain MRI Lesions, and Safety of 2 Dose Regimens of Ocrelizumab In Patients With RRMS
-
-
Genentech, H.L.R.1
-
11
-
-
33645812129
-
Regulatory CD56 (bright) natural killer cells mediate immunomodulatory effects of IL-2R alpha-targeted therapy (daclizumab) in multiple sclerosis
-
Bielekova B, Catalfamo M, Reichert-Scrivner S, et al. Regulatory CD56 (bright) natural killer cells mediate immunomodulatory effects of IL-2R alpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A. 2006;103(15):5941-5946.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.15
, pp. 5941-5946
-
-
Bielekova, B.1
Catalfamo, M.2
Reichert-Scrivner, S.3
-
12
-
-
2942537826
-
Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta
-
Bielekova B, Richert N, Howard T, et al. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proc Natl Acad Sci U S A. 2004;101(23):8705-8708.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.23
, pp. 8705-8708
-
-
Bielekova, B.1
Richert, N.2
Howard, T.3
-
13
-
-
65249138318
-
Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
-
Bielekova B, Howard T, Packer AN, et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol. 2009;66(4):483-489.
-
(2009)
Arch Neurol
, vol.66
, Issue.4
, pp. 483-489
-
-
Bielekova, B.1
Howard, T.2
Packer, A.N.3
-
14
-
-
54049093695
-
CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial
-
Viglietta V, Bourcier K, Buckle GJ, et al. CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial. Neurology. 2008;71(12):917-924.
-
(2008)
Neurology
, vol.71
, Issue.12
, pp. 917-924
-
-
Viglietta, V.1
Bourcier, K.2
Buckle, G.J.3
-
15
-
-
54449099880
-
FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology. 2008;71(16):1261-1267.
-
(2008)
Neurology
, vol.71
, Issue.16
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
-
16
-
-
70849086174
-
FTY720 (fingolimod) in multiple sclerosis: Therapeutic effects in the immune and the central nervous system
-
Brinkmann V. FTY720 (fingolimod) in multiple sclerosis: Therapeutic effects in the immune and the central nervous system. Br J Pharmacol. 2009;158(5):1173-1182.
-
(2009)
Br J Pharmacol
, vol.158
, Issue.5
, pp. 1173-1182
-
-
Brinkmann, V.1
-
19
-
-
45249107267
-
Effect of laquinimod on MRImonitored disease activity in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study
-
Comi G, Pulizzi A, Rovaris M, et al. Effect of laquinimod on MRImonitored disease activity in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;371(9630):2085-2092.
-
(2008)
Lancet
, vol.371
, Issue.9630
, pp. 2085-2092
-
-
Comi, G.1
Pulizzi, A.2
Rovaris, M.3
-
20
-
-
77955523211
-
-
Teva Pharmaceutical Industries, NCT00988052
-
Teva Pharmaceutical Industries. A multinational, multicenter, openlabel, single-assignment extension of the MS-LAQ-301 study, to evaluate the long-term safety, tolerability and effect on disease course of daily oral laquinimod 0.6 mg in subjects with relapsing multiple sclerosis. NCT00988052.
-
A Multinational, Multicenter, Openlabel, Single-assignment Extension of the MS-LAQ-301 Study, to Evaluate The Long-term Safety, Tolerability and Effect On Disease Course of Daily Oral Laquinimod 0.6 Mg In Subjects With Relapsing Multiple Sclerosis
-
-
-
21
-
-
0029846154
-
Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate
-
de Jong R, Bezemer AC, Zomerdijk TP, van de Pouw-Kraan T, Ottenhoff TH, Nibbering PH. Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate. Eur J Immunol. 1996;26(9):2067-2074.
-
(1996)
Eur J Immunol
, vol.26
, Issue.9
, pp. 2067-2074
-
-
de Jong, R.1
Bezemer, A.C.2
Zomerdijk, T.P.3
van de Pouw-Kraan, T.4
Ottenhoff, T.H.5
Nibbering, P.H.6
-
22
-
-
23044438515
-
Detoxication enzyme inducers modify cytokine production in rat mixed glial cells
-
Wierinckx A, Breve J, Mercier D, Schultzberg M, Drukarch B, Van Dam AM. Detoxication enzyme inducers modify cytokine production in rat mixed glial cells. J Neuroimmunol. 2005;166(1-2):132-143.
-
(2005)
J Neuroimmunol
, vol.166
, Issue.1-2
, pp. 132-143
-
-
Wierinckx, A.1
Breve, J.2
Mercier, D.3
Schultzberg, M.4
Drukarch, B.5
van Dam, A.M.6
-
23
-
-
33745051595
-
Oral fumaric acid esters for the treatment of active multiple sclerosis: An open-label, baseline-controlled pilot study
-
Schimrigk S, Brune N, Hellwig K, et al. Oral fumaric acid esters for the treatment of active multiple sclerosis: An open-label, baseline-controlled pilot study. Eur J Neurol. 2006;13(6):604-610.
-
(2006)
Eur J Neurol
, vol.13
, Issue.6
, pp. 604-610
-
-
Schimrigk, S.1
Brune, N.2
Hellwig, K.3
-
24
-
-
7644223637
-
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion
-
Korn T, Magnus T, Toyka K, Jung S. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion. J Leukoc Biol. 2004;76(5):950-960.
-
(2004)
J Leukoc Biol
, vol.76
, Issue.5
, pp. 950-960
-
-
Korn, T.1
Magnus, T.2
Toyka, K.3
Jung, S.4
-
26
-
-
77955543979
-
-
Sanofi-Aventis, NCT00475865
-
Sanofi-Aventis. A randomized, multinational, double-blind, placebocontrolled, parallel-group design pilot study to estimate the tolerability, safety, pharmacokinetics, and pharmacodynamic effects of teriflunomide for 24 weeks when added to treatment with glatiramer acetate in subjects with multiple sclerosis. NCT00475865.
-
A Randomized, Multinational, Double-blind, Placebocontrolled, Parallel-group Design Pilot Study to Estimate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamic Effects of Teriflunomide For 24 Weeks When Added to Treatment With Glatiramer Acetate In Subjects With Multiple Sclerosis
-
-
-
27
-
-
77955532182
-
-
Sanofi-Aventis, NCT00489489
-
Sanofi-Aventis. A randomized, multinational, double-blind, placebocontrolled, parallel-group design pilot study to estimate the tolerability, safety, pharmacokinetics, and pharmacodynamic effects of teriflunomide for 24 weeks when added to treatment with interferon-beta in subjects with multiple sclerosis. NCT00489489.
-
A Randomized, Multinational, Double-blind, Placebocontrolled, Parallel-group Design Pilot Study to Estimate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamic Effects of Teriflunomide For 24 Weeks When Added to Treatment With Interferon-beta In Subjects With Multiple Sclerosis
-
-
-
28
-
-
77955538842
-
-
Sanofi-Aventis, NCT00622700
-
Sanofi-Aventis. An international, multi-center, randomized, doubleblind, placebo-controlled, parallel group study to evaluate the efficacy and safety of two year treatment with teriflunomide 7 mg once daily and 14 mg once daily versus placebo in patients with a first clinical episode suggestive of multiple sclerosis. NCT00622700.
-
An International, Multi-center, Randomized, Doubleblind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Two Year Treatment With Teriflunomide 7 Mg Once Daily and 14 Mg Once Daily Versus Placebo In Patients With a First Clinical Episode Suggestive of Multiple Sclerosis
-
-
-
33
-
-
3042701267
-
The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination
-
Karnezis T, Mandemakers W, McQualter JL, et al. The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci. 2004;7(7):736-744.
-
(2004)
Nat Neurosci
, vol.7
, Issue.7
, pp. 736-744
-
-
Karnezis, T.1
Mandemakers, W.2
McQualter, J.L.3
-
34
-
-
27644507789
-
Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats
-
Liebscher T, Schnell L, Schnell D, et al. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol. 2005;58(5):706-719.
-
(2005)
Ann Neurol
, vol.58
, Issue.5
, pp. 706-719
-
-
Liebscher, T.1
Schnell, L.2
Schnell, D.3
-
35
-
-
9144268373
-
Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis
-
Fontoura P, Ho PP, DeVoss J, et al. Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol. 2004;173(11):6981-6992.
-
(2004)
J Immunol
, vol.173
, Issue.11
, pp. 6981-6992
-
-
Fontoura, P.1
Ho, P.P.2
Devoss, J.3
-
36
-
-
22844453047
-
LINGO-1 negatively regulates myelination by oligodendrocytes
-
Mi S, Miller RH, Lee X, et al. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci. 2005;8(6):745-751.
-
(2005)
Nat Neurosci
, vol.8
, Issue.6
, pp. 745-751
-
-
Mi, S.1
Miller, R.H.2
Lee, X.3
-
37
-
-
33846128124
-
NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
-
Lee X, Yang Z, Shao Z, et al. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci. 2007;27(1):220-225.
-
(2007)
J Neurosci
, vol.27
, Issue.1
, pp. 220-225
-
-
Lee, X.1
Yang, Z.2
Shao, Z.3
-
38
-
-
33846148013
-
TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions
-
Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Neuropathol Appl Neurobiol. 2007;33(1): 99-107.
-
(2007)
Neuropathol Appl Neurobiol
, vol.33
, Issue.1
, pp. 99-107
-
-
Satoh, J.1
Tabunoki, H.2
Yamamura, T.3
Arima, K.4
Konno, H.5
-
39
-
-
65249142739
-
Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
-
Mi S, Miller RH, Tang W, et al. Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann Neurol. 2009;65(3):304-315.
-
(2009)
Ann Neurol
, vol.65
, Issue.3
, pp. 304-315
-
-
Mi, S.1
Miller, R.H.2
Tang, W.3
-
40
-
-
70349881103
-
Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner
-
Rafei M, Campeau PM, Aguilar-Mahecha A, et al. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J Immunol. 2009;182(10):5994-6002.
-
(2009)
J Immunol
, vol.182
, Issue.10
, pp. 5994-6002
-
-
Rafei, M.1
Campeau, P.M.2
Aguilar-Mahecha, A.3
-
41
-
-
84979726329
-
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
-
Pluchino S, Quattrini A, Brambilla E, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003;422(6933):688-694.
-
(2003)
Nature
, vol.422
, Issue.6933
, pp. 688-694
-
-
Pluchino, S.1
Quattrini, A.2
Brambilla, E.3
|