Development and validation of a sensitive HPLC method for the quantification of HI-6 in guinea pig plasma and evaluated in domestic swine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 17-18, 2010, Pages 1407-1413

  Bohnert, Sara ^a   Vair, Cory ^a   Mikler, John ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

Author keywords

Guinea Pig; HI 6; HPLC; Ion Pair; Plasma; Swine; Validation

Indexed keywords

PHARMACOKINETICS; PLASMAS;

GUINEA PIGS; HI-6; HPLC; ION PAIRS; SWINE; VALIDATION;

MAMMALS;

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER DICHLORIDE; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER DIMETHANESULFONATE; UNCLASSIFIED DRUG; CHOLINESTERASE REACTIVATOR; OXIME; PRALIDOXIME; PYRIDINIUM DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; MALE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; SWINE; VALIDITY; ANIMAL; BLOOD; DRUG STABILITY; METHODOLOGY; STATISTICAL MODEL;

CAVIA; SUIDAE; SUS SCROFA DOMESTICA;

ANIMALS; CHOLINESTERASE REACTIVATORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; GUINEA PIGS; LINEAR MODELS; MALE; OXIMES; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SWINE;

EID: 77955507137     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.03.018     Document Type: Article

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