Is local radiotherapy still valuable for patients with multiple intrahepatic hepatocellular carcinomas?

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 5, 2010, Pages 1433-1440

  Koom, Woong Sub ^a   Seong, Jinsil ^a   Han, Kwang Hyub ^a   Lee, Do Yun ^a   Lee, Jong Tae ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Hepatocelluar carcinoma; Multiple intrahepatic tumors; Radiotherapy; Survival; Transcatheter arterial chemoembolization

Indexed keywords

CLINICAL TRIAL; CONVENTIONAL FRACTIONATIONS; FOUR-GROUP; GROUP 4; HEPATOCELLUAR CARCINOMA; HEPATOCELLULAR; MULTIPLE INTRAHEPATIC TUMORS; SURVIVAL; SURVIVAL RATE; TRANSCATHETER;

RADIOTHERAPY;

TUMORS;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER SIZE; CANCER SURVIVAL; CHEMOEMBOLIZATION; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; LIVER CELL CARCINOMA; MALE; MULTIPLE CANCER; PRIMARY TUMOR; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION FIELD; TREATMENT OUTCOME; TUMOR LOCALIZATION; ANALYSIS OF VARIANCE; EVALUATION; INTRAARTERIAL DRUG ADMINISTRATION; LIVER TUMOR; METASTASIS; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; RADIATION DOSE; REMISSION; SURVIVAL RATE; TUMOR VOLUME;

ADULT; AGED; ANALYSIS OF VARIANCE; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; COMBINED MODALITY THERAPY; FEMALE; HUMANS; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; RADIOTHERAPY DOSAGE; REMISSION INDUCTION; SURVIVAL RATE; TUMOR BURDEN;

EID: 77955505952     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.1676     Document Type: Article

References (28)

1. O. Nakashima, and M. Kojiro Recurrence of hepatocellular carcinoma: Multicentric occurrence or intrahepatic metastasis? A viewpoint in terms of pathology J Hepatobiliary Pancreat Surg 8 2001 404 409
2. M. Yamamoto, M. Matsuda, and Y. Iimuro Intrahepatic distant metastasis and metachronous multicentric occurrence in solitary hepatocellular carcinoma of less than five centimeters in diameter Surg Today 23 1993 969 978
3. J. Bruix Treatment of hepatocellular carcinoma Hepatology 25 1997 259 262
4. C.M. Lo, H. Ngan, and W.K. Tso Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 2002 1164 1171
5. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology 37 2003 429 442
6. J.M. Llovet, A. Burroughs, and J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917
7. J. Bruix, M. Sala, and J.M. Llovet Chemoembolization for hepatocellular carcinoma Gastroenterology 127 2004 S179 S188
8. J. Bruix, and M. Sherman Management of hepatocellular carcinoma Hepatology 42 2005 1208 1236
9. J. Fan, Z.Y. Tang, and Y.Q. Yu Improved survival with resection after transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma Dig Surg 15 1998 674 678
10. R.T. Poon, H. Ngan, and C.M. Lo Transarterial chemoembolization for inoperable hepatocellular carcinoma and postresection intrahepatic recurrence J Surg Oncol 73 2000 109 114
11. F. Trevisani, S. De Notariis, and C. Rossi Randomized control trials on chemoembolization for hepatocellular carcinoma: Is there room for new studies? J Clin Gastroenterol 32 2001 383 389
12. T.J. Vogl, M. Trapp, and H. Schroeder Transarterial chemoembolization for hepatocellular carcinoma: Volumetric and morphologic CT criteria for assessment of prognosis and therapeutic success - results from a liver transplantation center Radiology 214 2000 349 357
13. T. Livraghi, F. Meloni, and A. Morabito Multimodal image-guided tailored therapy of early and intermediate hepatocellular carcinoma: Long-term survival in the experience of a single radiologic referral center Liver Transpl 10 2004 S98 S106
14. W.J. Guo, and E.X. Yu Evaluation of combined therapy with chemoembolization and irradiation for large hepatocellular carcinoma Br J Radiol 73 2000 1091 1097
15. J. Seong, H.C. Park, and K.H. Han Local radiotherapy for unresectable hepatocellular carcinoma patients who failed with transcatheter arterial chemoembolization Int J Radiat Oncol Biol Phys 47 2000 1331 1335
16. J.C. Cheng, V.P. Chuang, and S.H. Cheng Unresectable hepatocellular carcinoma treated with radiotherapy and/or chemoembolization Int J Cancer 96 2001 243 252
17. Z.C. Zeng, Z.Y. Tang, and J. Fan A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma Cancer J 10 2004 307 316
18. S.J. Shim, J. Seong, and K.H. Han Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma Liver Int 25 2005 1189 1196
19. M.A. Hawkins, and L.A. Dawson Radiation therapy for hepatocellular carcinoma: From palliation to cure Cancer 106 2006 1653 1663
20. Liver Cancer Study Group of Japan The general rules for the clinical and pathological study of primary liver cancer [in Japanese] 4th ed. 2000 Kanehara Tokyo
21. T. Higuchi, M. Kikuchi, and M. Okazaki Hepatocellular carcinoma after transcatheter hepatic arterial embolization. A histopathologic study of 84 resected cases Cancer 73 1994 2259 2267
22. S. Ho, W.Y. Lau, and W.T. Leung Arteriovenous shunts in patients with hepatic tumors J Nucl Med 38 1997 1201 1205
23. K. Takayasu, Y. Shima, and Y. Muramatsu Hepatocellular carcinoma: Treatment with intraarterial iodized oil with and without chemotherapeutic agents Radiology 163 1987 345 351
24. J.C. Cheng, V.P. Chuang, and S.H. Cheng Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma Int J Radiat Oncol Biol Phys 47 2000 435 442
25. W.J. Guo, E.X. Yu, and L.M. Liu Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma World J Gastroenterol 9 2003 1697 1701
26. D.H. Wu, L. Liu, and L.H. Chen Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma World J Gastroenterol 10 2004 2184 2189
27. J. Seong, H.C. Park, and K.H. Han Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: A retrospective study of 158 patients Int J Radiat Oncol Biol Phys 55 2003 329 336
28. J. Seong, H.C. Park, and K.H. Han Clinical results of 3-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma in the cirrhotic patients Hepatol Res 27 2003 30 35