δ-catenin promotes malignant phenotype of non-small cell lung cancer by non-competitive binding to E-cadherin with p120ctn in cytoplasm

Journal of Pathology

Volumn 222, Issue 1, 2010, Pages 76-88

  Zhang, Jun Yi ^a   Wang, Yan ^a   Zhang, Di ^a   Yang, Zhi Qiang ^a   Dong, Xin Jun ^a   Jiang, Gui Yang ^a   Zhang, Peng Xin ^a   Dai, Shun Dong ^a   Dong, Qian Ze ^a   Han, Yang ^a   Zhang, Sheng ^a   Cui, Quan Zhe ^a   Wang, En Hua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

catenin; Co immunoprecipitation; E cadherin; Immunohistochemistry; NSCLC; P120ctn; Prognosis; Small GTPases

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MATRIGEL; MESSENGER RNA; PLAKOGLOBIN; UVOMORULIN;

ARTICLE; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PLASMID; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CATENINS; CELL CYCLE; CELL PROLIFERATION; COLLAGEN; CYTOPLASM; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LAMININ; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM STAGING; PHENOTYPE; PROGNOSIS; PROTEOGLYCANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 77955493793     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2742     Document Type: Article

References (28)

1. Liu Y, Xu HT, Dai SD, et al . Reduction of p120(ctn) isoforms 1 and 3 is significantly associated with metastatic progression of human lung cancer. APMIS 2007; 115: 848-856. (Pubitemid 47030109)
2. Liu Y, Wang Y, Zhang Y, et al . Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer 2009; 63: 375-382.
3. Xu HT, Wang L, Lin D, et al . Abnormal β-catenin and reduced axin expression are associated with poor differentiation and progression in non-small cell lung cancer. Am J Clin Pathol 2006; 125: 534-541.
4. Kosik KS, Donahue CP, Israely I, et al . δ-Catenin at the synaptic-adherens junction. Trends Cell Biol 2005; 15: 172-178.
5. Lu Q, Paredes M, Medina M, et al . δ-Catenin, an adhesive junction associated protein which promotes cell scattering. J Cell Biol 1999; 144: 519-532.
6. Rodova M, Kelly KF, VanSaun M, et al . Regulation of the rapsyn promoter by kaiso and δ-catenin. Mol Cell Biol 2004; 24: 7188-7196.
7. Burger MJ, Tebay MA, Keith PA, et al . Expression analysis of δ- catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer. Int J Cancer 2002; 100: 228-237.
8. Lu Q, Dobbs LJ, Gregory CW, et al . Increased expression of δ-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Hum Pathol 2005; 36: 1037-1048. (Pubitemid 41443254)
9. Paffenholz R, Franke WW. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation 1997; 61: 293-304. (Pubitemid 27440398)
10. Tanahashi H, Tabira T. Isolation of human δ-catenin and its binding specificity with presenilin 1. Neuroreport 1999; 10: 563-568. (Pubitemid 29333283)
11. Zhou J, Liyanage U, Medina M, et al . Presenilin interaction in the brain with a novel member of the armadillo family. Neuroreport 1997; 8: 2085-2090. (Pubitemid 27314338)
12. Ochiishi T, Futai K, Okamoto K, et al . Regulation of AMPA receptor trafficking by δ-catenin. Mol Cell Neurosci 2008; 39: 499-507.
13. Kim H, Han JR, Park J, et al . δ-Catenin induced dendritic morphogenesis: an essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem 2008; 283: 977-987.
14. Lu Q, Mukhopadhyay NK, Griffin JD, et al . Brain armadillo protein δ-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. J Neurosci Res 2002; 67: 618-624. (Pubitemid 34202797)
15. Arikkath J, Reichardt LF. Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci 2008; 31: 487-494.
16. Kim K, Sirota A, Chen YH, et al . Dendrite-like process formation and cytoskeletal remodeling regulated by δ-catenin expression. Exp Cell Res 2002; 275: 171-184. (Pubitemid 34948360)
17. Abu-Elneel K, Ochiishi T, Medina M, et al. A δ-catenin signaling pathway leading to dendritic protrusions. J Biol Chem 2008; 283: 32781-32791.
18. Vega FM, Ridley AJ. Snap shot: Rho family GTPases. Cell 2007; 129: 1430.
19. Sahai E, Marshall CJ. Rho-GTPases and cancer. Nature Rev Cancer 2002; 2: 133-142.
20. Liu Y, Dong QZ, Zhao Y, et al . p120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells. Exp Cell Res 2009; 315: 890-898.
21. Sobin LH, Wittekind C. Lung and pleural mesothelioma. In TNM Classification of Malignant Tumors (6th edn). John Wiley & Sons: New York, 2002; 97-104.
22. Travis WD, Brambilla E, Muller-Hermelink HK, et al . Tumors of the lung. In Tumors of the Lung, Pleura, Thymus and Heart (1st edn). IARC Press: Lyon, 2004; 44.
23. Dai SD, Wang Y, Jiang GY, et al . Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn. Lung Cancer 2010; 67: 205-215.
24. Huang FY, Chiu PM, Tam KF, et al . Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Gynecol Oncol 2006; 103: 219-225.
25. Zheng M, Simon R, Mirlacher M, et al . TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Am J Pathol 2004; 165: 63-69. (Pubitemid 38821814)
26. Lu Q, Abdul A, Chen YH, et al . δ-Catenin has the potential to promote the proliferation/survival and invasiveness of human cancer cells. Mol Biol Cell 2003; 14: 341a.
27. Yang I, Chang O, Lu Q, et al . δ-Catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin. Mol Cells 2010; 29: 233-237.
28. Zeng Y, Abdallah A, Lu JP, et al . δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles. Mol Cancer 2009; 8: 19.