Male Reproductive Health and Infertility

Primary Care - Clinics in Office Practice

Volumn 37, Issue 3, 2010, Pages 643-652

  Frey, Keith A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Male infertility; Men's health; Men's preventive healthcare; Preconception care

Indexed keywords

ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ASCORBIC ACID; CARNITINE; CAROTENOID; FOLIC ACID; GLUTATHIONE; SELENIUM; ZINC SULFATE;

ANTIOXIDANT ACTIVITY; AVOIDANCE BEHAVIOR; CHRONIC INFLAMMATION; CLINICAL EVALUATION; CLINICAL TRIAL; DIAGNOSTIC PROCEDURE; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG USE; ENVIRONMENTAL EXPOSURE; EPIDIDYMITIS; FAMILY HISTORY; FAMILY PLANNING; GENETIC RISK; HEALTH PROMOTION; HIGH RISK BEHAVIOR; HUMAN; IMMUNE STATUS; IMMUNIZATION; LABORATORY TEST; LIFESTYLE MODIFICATION; MALE INFERTILITY; MEDICAL HISTORY; MEN'S HEALTH; MENTAL HEALTH; NUTRITIONAL HEALTH; PATIENT CARE; PHYSICAL EXAMINATION; PHYSICIAN ATTITUDE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROGNOSIS; PROPHYLAXIS; PROSTATITIS; REPRODUCTIVE HEALTH; REVIEW; RISK ASSESSMENT; SEMEN ABNORMALITY; SEMEN ANALYSIS; SOCIAL LIFE; SOCIAL SUPPORT; STRESS MANAGEMENT; TREATMENT DURATION;

EID: 77955490549     PISSN: 00954543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pop.2010.04.005     Document Type: Review

References (36)

1. Frey K.A., Navarro S.M., Kotelchuck M., et al. The clinical content of preconception care: preconception care for men. Am J Obstet Gynecol 2008, 199(6 Suppl 2):S389-S395.
2. Dunlop A.L., Jack B., Frey K. National recommendations for preconception care: the essential role of the family physician. J Am Board Fam Med 2007, 20(1):81-84.
3. Padrón R., Dambay A., Suárez R., et al. Semen analyses in adolescent diabetic patients. Acta Diabetol 1984, 21:115-121.
4. Sipos A., Rasmussen F., Harrison G., et al. Paternal age and schizophrenia: a population based cohort study. BMJ 2004, 329:1070.
5. Malaspina D., Harlap S., Fennig S., et al. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry 2001, 58:361-367.
6. Marinelli D., Gaspari L., Pedotti P., et al. Mini-review of studies on the effect of smoking and drinking habits on semen parameters. Int J Hyg Environ Health 2004, 207:185-192.
7. Muthusami K.R., Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril 2005, 84:919-924.
8. Ewing J.A. Detecting alcoholism: the CAGE questionnaire. JAMA 1984, 252(14):1905-1907.
9. Torres-Calleja J., Gonzalez-Unzaga M., De- Celis-Carrillo R., et al. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci 2001, 68:1769-1774.
10. Ogden C.L., Carroll M.D., Curtin L.R., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555.
11. Sallmen M., Sandler D.P., Hoppin J.A., et al. Reduced fertility among overweight and obese men. Epidemiology 2006, 17:520-523.
12. Wong W.Y., Merkus H.M., Thomas C.M., et al. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril 2002, 77:491-498.
13. Kynaston H.G., Lewis-Jones D.I., Lynch R.V., et al. Changes in seminal quality following oral zinc therapy. Andrologia 1988, 20:21-22.
14. Omu A.E., Dashti H., Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Eur J Obstet Gynecol Reprod Biol 1998, 79:179-184.
15. Donnelly E.T., McClure N., Lewis S.E. The effect of ascorbate and alpha-tocopherol supplementation in vitro on DNA integrity and hydrogen peroxide-induced DNA damage in human spermatozoa. Mutagenesis 1999, 14:505-512.
16. Ramchandani P., Stein A., Evans J., et al. ALSPAC Study Team. Paternal depression in the postnatal period and child development: a prospective population study. Lancet 2005, 365:2201-2205.
17. Paulson J.F., Dauber S., Leiferman J.A. Individual and combined effects of postpartum depression in mothers and fathers on parenting behavior. Pediatrics 2006, 118:659-668.
18. Kahn R.S., Brandt D., Whitaker R.C. Combined effect of mothers' and fathers' mental health symptoms on children's behavioral and emotional well-being. Arch Pediatr Adolesc Med 2004, 158:721-729.
19. US Preventative Task Force Guide to clinical preventive services, 2007: recommendations of the US Preventative Services Task Force 2007, AHRQ Publication No. 07-05100, Agency for Healthcare Research and Quality, Rockville (MD), Available at:, Accessed April 29, 2010. http://www.ahrq.gov/clinic/pocketgd07/.
20. Frey K.A., Patel K.S. Initial evaluation and management of infertility by the primary care physician. Mayo Clin Proc 2004, 79(11):1439-1443.
21. Jose-Miller A.B., Boyden J.W., Frey K.A. Infertility. Am Fam Physician 2007, 75(6):849-856.
22. Whitman-Elia G.F., Baxley E.G. A primary care approach to the infertile couple. J Am Board Fam Pract 2001, 14:33-45.
23. Speroff L., Glass R.H., Kase N.G. Clinical Gynecologic Endocrinology and Infertility 1994, Williams & Wilkins, Baltimore (MD), p. 809-964. 5th edition.
24. Frey K.A. Infertility. Prim Care Rep 2003, 9:109-115.
25. American Urological Association, American Society for Reproductive Medicine Infertility: report on varicocele and infertility Available at:, Accessed April 29, 2010. http://www.asrm.org/Media/Practice/Report_on_varicocele.pdf.
26. Kolettis P.N. Evaluation of the subfertile man. Am Fam Physician 2003, 67:2165-2172. [published correction appears in Am Fam Physician 2003;68:1266].
27. American Urological Association, American Society of Reproductive Medicine Infertility: report on evaluation of the azoospermic male Available at:, Accessed April 29, 2010. http://www.asrm.org/Media/Practice/Evaluation_of_the_azoospermic.pdf.
28. Harrison K.L., Callan V.J., Hennessey J.F. Stress and semen quality in an in vitro fertilization program. Fertil Steril 1987, 48:633-636.
29. Pook M., Tuschen-Caffier B., Krause W. Is infertility a risk factor for impaired male fertility?. Hum Reprod 2004, 19:954-959.
30. Clarke R.N., Klock S.C., Geoghegan A., et al. Relationship between psychological stress and semen quality among in-vitro fertilization patients. Hum Reprod 1999, 14:753-758.
31. Ragni G., Caccamo A. Negative effect of stress of in vitro fertilization program on quality of semen. Acta Eur Fertil 1992, 23:21-23.
32. Pellicer A., Ruiz M. Fertilization in vitro of human oocytes by spermatozoa collected in different stressful situations. Hum Reprod 1989, 4:817-820.
33. National Institute of Occupational Safety and Health The effects of workplace hazards on male reproductive health. Centers for Disease Control and Prevention DHHS (NIOSH) Publication No. 96-132. Available at:, Accessed April 29, 2010. http://www.cdc.gov/niosh/malrepro.html.
34. Brown JA Haz-map database. Infertility, male Available at:, Accessed April 29, 2010. http://hazmap.nlm.nih.gov/index.html.
35. Jensen T.K., Bonde J.P., Joffe M. The influence of occupational exposure on male reproductive function. Occup Med (Lond) 2006, 56:544-553.
36. Files J.A., David P.S., Frey K.A. The patient-centered medical home and preconception care: an opportunity for internists. J Gen Intern Med 2008, 23(9):1518-1520.