A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: Application in a guinea pig model

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 17-18, 2010, Pages 1420-1425

  Capacio, B R ^a   Dusick, B ^a   Smith, J R ^a   McDonough, J H ^a   Shih, T M ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Analysis; Bis Pyridinium oxime(s); GC MS; Liquid chromatography; Mass spectrometry; Nerve agent; Pharmacokinetics

Indexed keywords

ANIMALS; CHROMATOGRAPHY; LIQUIDS; MAMMALS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; SPECTROMETRY;

ACCURACY ASSESSMENT; ANALYSIS; CALIBRATION CURVES; GC-MS; LOWER LIMIT OF QUANTIFICATIONS; NERVE AGENTS; PLASMA CONCENTRATION; PYRIDINIUM;

LIQUID CHROMATOGRAPHY;

1 (2 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE; BIS(PYRIDINIUM OXIME) DERIVATIVE; CYCLOSARIN; ICD 585; SARIN; UNCLASSIFIED DRUG; 1 ((4 (AMINOCARBONYL)PYRIDINIO)TRIMETHYLENE) 2 ((HYDROXYIMINO)METHYL)PYRIDINIUM; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1-((4-(AMINOCARBONYL)PYRIDINIO)TRIMETHYLENE)-2-((HYDROXYIMINO)METHYL)PYRIDINIUM; CHOLINESTERASE REACTIVATOR; OXIME; PYRIDINIUM DERIVATIVE;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFICACY; DRUG STABILITY; FREEZE THAWING; GUINEA PIG; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; ROOM TEMPERATURE; SENSITIVITY AND SPECIFICITY; ANIMAL; BLOOD; METHODOLOGY; REPRODUCIBILITY; STATISTICAL MODEL; SWINE; TEMPERATURE;

ANIMALIA; CAVIA;

ANIMALS; CALIBRATION; CHOLINESTERASE REACTIVATORS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; GUINEA PIGS; LINEAR MODELS; MASS SPECTROMETRY; MODELS, ANIMAL; OXIMES; PYRIDINIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUS SCROFA; TEMPERATURE;

EID: 77955478712     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.12.011     Document Type: Article

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