Does methadone prolong QTc intervals by depleting testosterone levels?

Archives of Internal Medicine

Volumn 170, Issue 15, 2010, Pages 1407-1408

  Daniell, Harry W ^a  

^a A Medical Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; METHADONE; OPIATE; SEX HORMONE; TESTOSTERONE;

ANDROGEN DEFICIENCY; ANDROGEN THERAPY; HEART REPOLARIZATION; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; TORSADE DES POINTES;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HUMANS; MALE; METHADONE; NARCOTICS; TESTOSTERONE;

EID: 77955451287     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.282     Document Type: Letter

References (5)

1. Ansermot N, Albayrak O, Schlapfer J, et al. Substitution of (R,S)-methadone by (R)-methadone: impact on QTc interval. Arch Intern Med. 2010;170(6): 529-536.
2. James AF, Hancox JC. Sex, drugs and arrhythmia: are gender differences in risk of torsades-de-pointes simply a matter of testosterone? Cardiovasc Res. 2003;57(1):1-4.
3. Bidoggia H, Maciel J, Capalozza N, et al. Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am Heart J. 2000;140(4):678-683.
4. Daniell HW. Hypogonadism in men consuming sustained-action oral opioids. J Pain. 2002;3(5):377-384.
5. Bliesener N, Albrecht S, Schwager A, Weckbecker K, Lichtermann D, Klingmüller D. Plasma testosterone and sexual function inmen receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metab. 2005; 90(1):203-206. (Pubitemid 40116658)