Variations in TIMP3 are associated with age-related macular degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 28, 2010, Pages

  Kaur, Inderjeet ^a   Rathi, Sonika ^a   Chakrabarti, Subhabrata ^a  

^a L V PRASAD EYE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DECORIN; EPIPHYCAN; FIBULIN 5; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LUMICAN; PROTEIN FIBULIN 6; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

BRUCH MEMBRANE; EXTRACELLULAR MATRIX; GENE CLUSTER; GENE FREQUENCY; GENE MAPPING; GENE SEQUENCE; GENOTYPE; HAPLOTYPE; HUMAN; LETTER; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RETINA MACULA AGE RELATED DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM;

FLUORESCEIN ANGIOGRAPHY; HUMANS; MACULAR DEGENERATION;

EID: 77955448017     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007476107     Document Type: Letter

References (4)

1. Chen W, et al. (2010) Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA 107:7401-7406.
2. Kaur I, et al. (2008) Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci 49:1771-1776.
3. Kamei M, Hollyfield JG (1999) TIMP-3 in Bruch's membrane: Changes during aging and in age-related macular degeneration. Invest Ophthalmol Vis Sci 40:2367-2375. (Pubitemid 29418393)
4. Strunnikova NV, et al. (2010) Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet 19:2468-2486.