Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells

Cancer Prevention Research

Volumn 3, Issue 8, 2010, Pages 910-916

  Jin, Peng ^a   Lu, Xiao Juan ^a   Sheng, Jian Qiu ^a   Fu, Lei ^a   Meng, Xiao Ming ^a   Wang, Xin ^a   Shi, Tai Ping ^b   Li, Shi Rong ^a   Rao, Jianyu ^c,d  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PROTEIN MLH1; PROTEIN MSH2;

ARTICLE; CANCER CELL CULTURE; CLINICAL ARTICLE; COLON CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ESTRADIOL BLOOD LEVEL; FEMALE; GENE; HMLH1 GENE; HMSH2 GENE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; CELLS, CULTURED; COLON; DNA MISMATCH REPAIR; EPITHELIAL CELLS; ESTRADIOL; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NUCLEAR PROTEINS; UP-REGULATION; YOUNG ADULT;

EID: 77955438748     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-09-0228     Document Type: Article

References (17)

1. Ries LA, Wingo PA, Miller DS, et al. The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer. Cancer 2000;88:2398-424.
2. Gaglia P, Atkin WS, Whitelaw S, et al. Variables associated with the risk of colorectal adenomas in asymptomatic patients with a family history of colorectal cancer. Gut 1995;36:385-90.
3. Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, et al. Estrogen plus Progestin and colorectal cancer in postmenopausal women. N Engl J Med 2004;350:991-1004.
4. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
5. Kennelly R, Kavanagh DO, Hogan AM, Winter DC. Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol 2008;9:385-91.
6. Slattery ML, Potter JD, Curtin K, et al. Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer. Cancer Res 2001;61:126-30.
7. Miyamoto T, Shiozawa T, Kashima H, et al. Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells. Endocrinology 2006;147:4863-70.
8. Morimoto H, Tsukada J, Kominato Y, Tanaka Y. Reduced expression of human mismatch repair genes in adult T-cell leukemia. Am J Hematol 2005;78:100-7.
9. Shiozawa T, Miyamoto T, Kashima H, Nakayama K, Nikaido T, Konishi I. Estrogen-induced proliferation of normal endometrial glandular cells is initiated by transcriptional activation of cyclin D1 via binding of c-Jun to an AP-1 sequence. Oncogene 2004;23:8603-10.
10. Sheng JQ, Chan TL, Chan YW, et al. Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. Chin J Dig Dis 2006;7:197-205.
11. Froggatt NJ, Green J, Brassett C, et al. A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. J Med Genet 1999;36:97-102.
12. Qiu Y, Waters CE, Lewis AE, Langman MJS, Eggo MC. Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor β. J Endocrinol 2002;174:369-77.
13. Irving JA, Dupuis B, Wang L, Gilks CB. Cyclical expression of the DNA mismatch repair enzyme hMLH1 in normal endometrium. Fertil Steril 2002;78:195-6.
14. Cho NL, Javid SH, Carothers AM, et al. Estrogen receptors α and β are inhibitory modifiers of APC-dependent tumorigenesis in the proximal colon of Min/+ mice. Cancer Res 2007;67:2366-72.
15. Wada-Hiraike O, Imamov O, Hiraike H, et al. Role of estrogen receptor β in colonic epithelium. Proc Natl Acad Sci U S A 2006;103: 2959-64.
16. Linsalata M, Russo F, Notarnicola M, et al. Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. Nutr Cancer 2005;52:84-93. (Pubitemid 41232653)
17. Hawn MT, Umar A, Carethers JM, et al. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 1995;55:3721-5.