A new hydrogel drug delivery system based on Hydroxyethylstarch derivatives

Journal of Microencapsulation

Volumn 27, Issue 5, 2010, Pages 400-408

  Harling, Steffen ^a   Schwoerer, Ariane ^a   Scheibe, Kristin ^a   Daniels, Rolf ^b   Menzel, Henning ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cross linking; in vitro release; Microparticles; Polymer synthesis; Protein delivery

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; HETASTARCH; HYDROXYETHYLMETHACRYLATCARBONYL HYDROXYETHYL STARCH; LYSOZYME; MACROGOL; MICROSPHERE; PEPTIDE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; DRUG DELIVERY SYSTEM; EMULSION; HYDROGEL; PARTICLE SIZE; PHOTOPOLYMERIZATION; POLYMERIZATION; SWELLING;

EID: 77955434217     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040903367301     Document Type: Article

References (24)

1. Akkar A, Namsolleck P, Blaut M, Miiller RH. 2004. Solubilizing poorly soluble antimycotic agents by emulsification via a solvent-free process. AAPS PharmSciTech 5:24.
2. Barisch S. 2009. Einfluss von Kryoprotektoren auf Hydroxyethylstarke- basierte Hydrogele als Drug Delivery Systeme fur die kontrollierte Freisetzung von Proteinen. Dissertation, Eberhard Karls Universitat Tubingen.
3. Bunjes H, Wengst J, Daniels R. 2007. Multiple Emulsionen für den Pharmabereich. In: Muschiolik G, Bunjes H, editors. Multiple Emulsionen, Hamburg: Behrs Verlag. pp 207-268.
4. Crowther JR, 1995. Methods in molecular biology, ELISA; theory and practice. Vol.42, Berlin: Springer, Humana Press.
5. Elversson J, Millqvist-Fureby A. 2005. Aqueous two-phase systems as a formulation concept for spray-dried protein. Int J Pharm 294:73-87.
6. Fitzpatrick F, Schagerlof H, Andersson T, Richardson S, Tjerneld F, Wahlhund K-G, Wittgren B. 2006. NMR, cloud-point measurements and enzymatic depolymerization: Complementary tools to investigate substituents patterns in modified celluloses. Biomacromolecules 7:2909-2917.
7. Flory PJ, 1953. Principles of polymer chemistry. Ithaca, NY: Cornell University Press.
8. Franssen O, Hennink WE. 1998. A novel preparation method for polymeric microparticles without the use of organic solvents. Int J Pharm 168:1-7.
9. Franssen O, Vos OP, Hennink WE. 1997. Delayed release of a model protein from enzymatically-degrading dextran hydrogels. J Contr Rel 44:237-245.
10. Franz, TJ. 1975. Percutaneous absorption on the relevance of in vitro data. J. Invest. Derm. 64:190.
11. Hennink WE, van Nostrum CF. 2002. Novel crosslinking methods to design hydrogels. Adv Drug Del Rev 54:13-36.
12. Hoffman AS. 2002. Hydrogels for biomedical applications. Adv Drug Del Rev 43:3-12.
13. Kostanski JW, De Luca PP. 2000. A novel in vitro release technique for peptide-containing biodegradable microspheres. AAPS PharmSCITech 1:4.
14. Kulicke WM, Roessner D, Kull W. 1993. Characterization of hydroxyethylstarch by polymer analysis for use as a plasma volume expander. Starch/Starke 12:445-450.
15. Lawin P, Zander J, Weidler B, 1989. Hydroxyethylstaerke -eine aktuelle Uebersicht. Stuttgart: Georg Thieme Verlag; 1989.
16. Peng T, Yao K, Yuan C, Goosen M. 1994. Structural changes of pH-sensitive chitosan/polyether hydrogels in different pH solutions. J Polym Sci A Polym Chem 32:591-596.
17. Peppas NA. 1986. Hydrogels in medicine and pharmacy. Vol.1, Fundamentals. Boca Raton: CRC Press.
18. Scheibe K. 2003. A new aqueous two phase system based on hydroxyethyl-starch and polyethelenglycol. Poster Proceedings of the Annual meeting on the Controlled Release Society local chapter Germany, Munich.
19. Stenekes RJH, Franssen O, van Bommel EMG, Crommelin DJA, Hennink WE. 1998. The preparation of dextran microspheres in an all-aqueous system: Effect of the formulation parameters on particle characteristics. Pharm Res 15:557-561.
20. Stenekes RJH, Franssen O, van Bommel EMG, Crommelin DJA, Hennink W. 1999. The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres. Int J Pharm 183:29-32.
21. van Dijk-Wolthuis WNE, Franssen O, Talsma H, van Steenbergen MJ, van der Bosch JJK, Hennink WE. 1995. Synthesis, characterization, and polymerization of glycidyl methacrylate derivatized dextran. Macromolecules 28:6317-6322.
22. van Dijk-Wolthuis WNE, Hoogeboom JAM, van Steenbergen MJ, Tsang SKY, Hennink WE. 1997a. Degradation and release behavior of dextran-based hydrogels. Macromolecules 30:4639-4645.
23. van Dijk-Wolthuis WNE, Tsang SKY, van der Bosch JJK, Hennink WE. 1997b. A new class of polymerizable dextrans with hydrolyzable groups: Hydroxyethylmethacrylated dextran with and without oligolactate spacer. Polymer 38:6235-6242.
24. van Dijk-Wolthuis WNE, van Steenbergen MJ, Underberg WJM, Hennink WE. 1997c. Degradation kinetics of methacrylates dextrans in aqueous solution. J Pharm Sci 86:413-417.