Effects of solvent combinations on drug release from injectable phase sensitive liquid implants;Enjekte Edilebilen Faz Duyarh Sıvı Implanttan Etkin Madde Sahmına Çözücü Bileşimlerinin Etkilerinin Deǧerlendirilmesi

Turkish Journal of Pharmaceutical Sciences

Volumn 7, Issue 1, 2010, Pages 49-56

  Yapar, Evren Alǧin ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Granisetron HCl; In situ implant; Injectable; Phase sensitive; Poly(DI lactide co glycolide)

Indexed keywords

1 METHYL 2 PYRROLIDINONE; BENZYL ALCOHOL; BENZYL BENZOATE; DIMETHYL SULFOXIDE; GLYCEROL; GRANISETRON; MACROGOL 400; PROPYLENE CARBONATE; RESOMER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG IMPLANT; DRUG RELEASE; DRUG SOLUBILITY; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; LD 50; MOUSE; NONHUMAN; RAT; SOLVENT EFFECT;

EID: 77955433247     PISSN: 1304530X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Dunn, R.L., Tipton, A.J., "Polymeric compositions useful as controlled release implants", US Patent 5.702.716, 1997.
2. Brodbeck, K.J., Gaynor-Duarte, A.T., Shen, T.T.I., "Gel composition and methods", US Patent 6.130.200, 2000.
3. DesNoyer, J.R., McHugh, A.J., "The effect of Pluronic on the protein release kinetics of an injectable drug delivery system", J. Control. Release, 86, 24-55, 2003.
4. Brodbeck, K.J., DesNoyer, J.R., McHugh, A.J., "Phase inversion dynamics of PLGA solutions related to drug delivery: Part II. The role of solution thermodynamics and bath side mass transfer", J. Control. Releas., 62, 333-344, 1999.
5. Tsay, C.S., McHugh, A.J., "Mass transfer modeling of asymmetric membrane formation by phase inversion", J. Polym. Sci., B, Polym. Phys., 28, 1327-1365, 1990.
6. Graham, P.D., Brodbeck, K.J., McHugh, A.J., "Phase inversion dynamics of PLGA solutions related to drug delivery", J. Control. Release, 58, 233-245, 1999.
7. Raman, C., McHugh A.J., "A model for drug release from fast phase inverting injectable solutions", J. Control. Releas., 102, 145-157, 2005.
8. Aapro, M., "Granisetron: an update on its clinical use in the management of nausea and vomiting", The Oncologist, 9, 673, 2004.
9. ALOGPS 2.1 Virtual Computational Chemistry Laboratory, 2001. http://www.vcclab.org/lab/alogps/
10. Algin Yapar, E., "Development of Sustained Drug Delivery Systems as In situ Forming Injectable Implants", PhD Thesis., 2009.
11. Mchugh, A.J. "The role of polymer membrane formation in sustained release drug delivery systems", J. Control. Releas., 109, 211-221, 2005.
12. Astaneh, R., Erfan, M., Moghimi, H.R., Mobedi, H. "Changes in morphology of in situ forming plga implant prepared by different polymer molecular weight and its effect on release behavior", J. of Pharm. Sci., DOI 10.1002/jps.21415, 2008.
13. Rafienia, M., Mirzadeh, H., Mobedi., H., Jamshidi, A. "In vitro evaluation of drug solubility and gamma irradiation on the release of betamethasone under similated in vivo conditions", J. Bioactive and Compatible Polymer., 22, 443-459, 2007.
14. Chen, S., Singh, J., "Controlled delivery of testosterone from smart polimer solution based systems: in vitro evaluation", Int. J.Pharm., 295, 183-190, 2005.
15. Alpar R., Öner L., "Regresyon çözümlemesi", Fabad J. Pharm. Sci., 13: 556-565, 1988.