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Volumn 878, Issue 24, 2010, Pages 2274-2279
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Determination of dehydroandrographolide succinate in human plasma by liquid chromatography tandem mass spectrometry (LC-MS/MS): Method development, validation and clinical pharmacokinetic study
a,b
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Author keywords
Dehydroandrographolide succinate; Human plasma; LC MS MS; Pharmacokinetic study; Protein precipitation
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Indexed keywords
CHRONIC BRONCHITIS;
CLINICAL PHARMACOKINETICS;
CORRELATION COEFFICIENT;
ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY;
GOOD STABILITY;
HUMAN PLASMAS;
ION TRANSITION;
LC-MS/MS;
LIMIT OF DETECTION;
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;
LOWER LIMIT OF QUANTIFICATIONS;
MATRIX EFFECTS;
METHOD DEVELOPMENT;
METHOD VALIDATIONS;
MULTIPLE-REACTION MONITORING MODES;
PHARMACOKINETIC STUDIES;
PROTEIN PRECIPITATION;
TRADITIONAL CHINESE MEDICINE;
UPPER RESPIRATORY TRACT;
ELECTRONIC WARFARE;
ELECTROSPRAY IONIZATION;
LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
MEDICINE;
PHARMACOKINETICS;
PLASMAS;
PROTEINS;
PULMONARY DISEASES;
PLASMA (HUMAN);
14 DEOXY 11,12 DIDEHYDROANDROGRAPHOLIDE 3,19 DISUCCINATE;
CHINESE DRUG;
DITERPENOID;
FORMONONETIN;
LACTONE;
UNCLASSIFIED DRUG;
ACCURACY;
ADULT;
ARTICLE;
BLOOD SAMPLING;
CONTROLLED STUDY;
DRUG DETERMINATION;
DRUG STRUCTURE;
FEMALE;
HUMAN;
HUMAN EXPERIMENT;
LIQUID CHROMATOGRAPHY;
MALE;
MOLECULAR STABILITY;
NEGATIVE ION ELECTROSPRAY;
NORMAL HUMAN;
PLASMA CONCENTRATION-TIME CURVE;
PRECIPITATION;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
SINGLE DRUG DOSE;
TANDEM MASS SPECTROMETRY;
ADULT;
CHI-SQUARE DISTRIBUTION;
CHROMATOGRAPHY, LIQUID;
DITERPENES;
DRUG STABILITY;
DRUGS, CHINESE HERBAL;
FEMALE;
HUMANS;
MALE;
REPRODUCIBILITY OF RESULTS;
SUCCINATES;
TANDEM MASS SPECTROMETRY;
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EID: 77955422412
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2010.06.030 Document Type: Article |
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Times cited : (4)
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References (7)
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