Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4412-4415

  Kamada, Rui ^a   Yoshino, Wataru ^a   Nomura, Takao ^a   Chuman, Yoshiro ^a   Imagawa, Toshiaki ^a   Suzuki, Takanori ^a   Sakaguchi, Kazuyasu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Calixarene; Li Fraumeni syndrome; p53 mutation; Stabilization; Tetramerization domain

Indexed keywords

CALIX[6]ARENE DERIVATIVE; CALIXARENE; GUANIDINE; HEXA(1 IMIDAZOLYLMETHYL) 37,38,39,40,41,41 HEXAMETHOXYCALIX[6]ARENE; IMIDAZOLE DERIVATIVE; OLIGOMER; PROTEIN P53; PYRAZOLE DERIVATIVE; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; PROTEIN STABILITY; PROTEIN STRUCTURE;

CALIXARENES; HUMANS; LI-FRAUMENI SYNDROME; MOLECULAR CONFORMATION; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; THERMODYNAMICS; TRANSCRIPTION, GENETIC; TRANSITION TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955421938     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.053     Document Type: Article

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