Regional adiposity and risk for coronary artery disease in type 1 diabetes: Does having greater amounts of gluteal-femoral adiposity lower the risk?

Diabetes Research and Clinical Practice

Volumn 89, Issue 3, 2010, Pages 288-295

  Shay, Christina M ^a,c   Secrest, Aaron M ^a   Goodpaster, Bret H ^b   Kelsey, Sheryl F ^a   Strotmeyer, Elsa S ^a   Orchard, Trevor J ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Adiposity; Coronary artery disease; Dual X ray absorptiometry; EDC Study; Gluteal femoral adiposity; Type 1 diabetes

Indexed keywords

ADULT; ARTICLE; BODY FAT DISTRIBUTION; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LEG; MAJOR CLINICAL STUDY; MALE; OBESITY; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SEX DIFFERENCE; TRUNK;

EID: 77955418580     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.03.028     Document Type: Article

References (29)

1. Warram J.H., Laffel L.M., Ganda O.P., Christlieb A.R. Coronary artery disease is the major determinant of excess mortality in patients with insulin-dependent diabetes mellitus and persistent proteinuria. J. Am. Soc. Nephrol. 1992, 3:S104-110.
2. Orchard T.J., Costacou T., Kretowski A., Nesto R.W. Type 1 diabetes and coronary artery disease. Diabetes Care 2006, 29:2528-2538.
3. Canoy D. Distribution of body fat and risk of coronary heart disease in men and women. Curr. Opin. Cardiol. 2008, 23:591-598.
4. Buchholz A.C., Bugaresti J.M. A review of body mass index and waist circumference as markers of obesity and coronary heart disease risk in persons with chronic spinal cord injury. Spinal Cord 2005, 43:513-518.
5. Soedamah-Muthu S.S., Chaturvedi N., Witte D.R., Stevens L.K., Porta M., Fuller J.H. Relationship between risk factors and mortality in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study (PCS). Diabetes Care 2008, 31:1360-1366.
6. Ding J., Visser M., Kritchevsky S.B., Nevitt M., Newman A., Sutton-Tyrrell K., et al. The association of regional fat depots with hypertension in older persons of white and African American ethnicity. Am. J. Hypertens. 2004, 17:971-976.
7. Nicklas B.J., Penninx B.W., Ryan A.S., Berman D.M., Lynch N.A., Dennis K.E. Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. Diabetes Care 2003, 26:1413-1420.
8. Van Pelt R.E., Evans E.M., Schechtman K.B., Ehsani A.A., Kohrt W.M. Contributions of total and regional fat mass to risk for cardiovascular disease in older women. Am. J. Physiol. 2002, 282:E1023-1028.
9. Goodpaster B.H., Thaete F.L., Kelley D.E. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am. J. Clini. Nutr. 2000, 71:885-892.
10. Goodpaster B.H., Thaete F.L., Simoneau J.A., Kelley D.E. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997, 46:1579-1585.
11. Aasen G., Fagertun H., Halse J. Regional fat mass by DXA: high leg fat mass attenuates the relative risk of insulin resistance and dyslipidaemia in obese but not in overweight postmenopausal women. Scand. J. Clin. Lab. Invest. 2008, 68:204-211.
12. Snijder M.B., Visser M., Dekker J.M., Goodpaster B.H., Harris T.B., Kritchevsky S.B., et al. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia 2005, 48:301-308.
13. Orchard T.J., Dorman J.S., Maser R.E., Becker D.J., Drash A.L., Ellis D., et al. Prevalence of complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications study II. Diabetes 1990, 39:1116-1124.
14. Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 1973, 19:476-482.
15. 2+ quantitation of high-density-lipoprotein cholesterol: an ultrafiltration procedure for lipemic samples. Clin. Chem. 1978, 24:900-904.
16. Williams K.V., Erbey J.R., Becker D., Arslanian S., Orchard T.J. Can clinical factors estimate insulin resistance in type 1 diabetes?. Diabetes 2000, 49:626-632.
17. Bos G., Snijder M.B., Nijpels G., Dekker J.M., Stehouwer C.D., Bouter L.M., et al. Opposite contributions of trunk and leg fat mass with plasma lipase activities: the Hoorn study. Obes. Res. 2005, 13:1817-1823.
18. Snijder M.B., Dekker J.M., Visser M., Bouter L.M., Stehouwer C.D., Yudkin J.S., et al. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study. Diabetes care 2004, 27:372-377.
19. Snijder M.B., Flyvbjerg A., Stehouwer C.D., Frystyk J., Henry R.M., Seidell J.C., et al. Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study. Eur. J. Endocrinol. 2009, 160:387-395.
20. Van Pelt R.E., Jankowski C.M., Gozansky W.S., Schwartz R.S., Kohrt W.M. Lower-body adiposity and metabolic protection in postmenopausal women. J. Clin. Endocrinol. Metab. 2005, 90:4573-4578.
21. Sakai Y., Ito H., Egami Y., Ohoto N., Hijii C., Yanagawa M., et al. Favourable association of leg fat with cardiovascular risk factors. J. Intern. Med. 2005, 257:194-200.
22. Lovejoy J.C., Sainsbury A. Sex differences in obesity and the regulation of energy homeostasis. Obes. Rev. 2009, 10:154-167.
23. Aasen G., Fagertun H., Tonstad S., Halse J. Leg fat mass as measured by dual X-ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men. Scand. J. Clin. Lab. Invest. 2009, 69:181-189.
24. Strotmeyer E.S., Cauley J.A., Orchard T.J., Steenkiste A.R., Dorman J.S. Middle-aged premenopausal women with type 1 diabetes have lower bone mineral density and calcaneal quantitative ultrasound than nondiabetic women. Diabetes Care 2006, 29:306-311.
25. Smith S.R., Lovejoy J.C., Greenway F., Ryan D., deJonge L., de la Bretonne J., et al. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 2001, 50:425-435.
26. Tanko L.B., Bagger Y.Z., Alexandersen P., Larsen P.J., Christiansen C. Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 2003, 107:1626-1631.
27. Tatsukawa M., Kurokawa M., Tamari Y., Yoshimatsu H., Sakata T. Regional fat deposition in the legs is useful as a presumptive marker of antiatherogenesity in Japanese. Proc. Soc. Exp. Biol. Med. 2000, 223:156-162.
28. Hara M., Saikawa T., Kurokawa M., Sakata T., Yoshimatsu H. Leg fat percentage correlates negatively with coronary atherosclerosis. Circ. J. 2004, 68:1173-1178.
29. Bestetti A., Castini D., Bigi R., Maioli C., Lombardi F., Gregori D., et al. Truncal fat determined by dual-energy X-ray absorptiometry is an independent predictor of coronary artery disease extension. Eur. J. Cardiovasc. Prev. Rehabil. 2008, 15:428-433.