A one-pot three-component reaction to access 1-alkyl-2-aryl-5- nitrobenzimidazoles under solvent-free conditions

Tetrahedron Letters

Volumn 51, Issue 33, 2010, Pages 4459-4461

  Romero, F Anthony ^a   Moningka, Remond ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 2 5 NITROBENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; SUBSTITUTION REACTION;

EID: 77955418265     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.06.094     Document Type: Article

References (10)

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7. Example of benzimidazole formation from a phenylenediamine and aldehyde using air as the oxidant: Y. Li, N. Zhao, Y.-L. Wang, and J.-Y. Wang Henan Shifan Daxue Xuebao Bianjibu 36 2008 92
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9. 3, 100 MHz) δ 158.2, 143.6, 142.4, 141.2, 130.9, 130.4, 130.2, 129.4, 118.4, 115.7, 112.7, 59.9, 48.0.
10. The reaction is run under a sealed vial to prevent the loss of the volatile primary amine. Although a sealed vial is used, no care is used to exclude air from the reaction vessel.