The clinical pattern, prevalence, and factors associated with immune reconstitution inflammatory syndrome in Ugandan children

AIDS

Volumn 24, Issue 13, 2010, Pages 2009-2017

  Orikiiriza, Judy ^a   Bakeera Kitaka, Sabrina ^a   Musiime, Victor ^b   Mworozi, Edison A ^a   Mugyenyi, Peter ^b   Boulware, David R ^c  

^a MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^b JOINT CLINICAL RESEARCH CENTRE   (Uganda)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

antiretroviral therapy; children; complications; HIV; immune reconstitution inflammatory syndrome

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADOLESCENT; ANEMIA; ARTICLE; AWARENESS; BACTERIAL PNEUMONIA; CAREGIVER; CD4+ T LYMPHOCYTE; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; CONFIDENCE INTERVAL; COUGHING; ENCEPHALITIS; FEMALE; FEVER; HEALTH CARE PERSONNEL; HEPATOMEGALY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOSUPPRESSIVE TREATMENT; KAPOSI SARCOMA; LUNG TUBERCULOSIS; LYMPHADENITIS; LYMPHADENOPATHY; MALE; MOLLUSCUM CONTAGIOSUM; MOUTH LESION; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; OPPORTUNISTIC INFECTION; OTITIS MEDIA; PATIENT COMPLIANCE; PEDIATRIC HOSPITAL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RISK; RISK FACTOR; SCHOOL CHILD; SPLENOMEGALY; THROMBOCYTOPENIA; THRUSH; UGANDA; UNIVARIATE ANALYSIS;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INCIDENCE; MALE; MEDICATION ADHERENCE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; UGANDA;

EID: 77955416688     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833b260a     Document Type: Article

References (30)

1. Hirsch HH, Kaufmann G, Sendi P, Battegay M. Immune recon-stitution in HIV-infected patients. Clin Infect Dis 2004; 38:1159-1166.
2. Resino S, Resino R, Maria Bellón J, Micheloud D, Gutiérrez MD, de José MI, et al. Long-term effects of highly active antiretro-viral therapy in pretreated vertically HIV type 1 Infected children: 6yrs of follow up. Clin Infect Dis 2006; 42:862-869.
3. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998; 338:853-860.
4. Michelet C, Arvieux C, François C, Besnier JM, Rogez JP, Breux JP, et al. Opportunistic infections occurring during highly active antiretroviral treatment. AIDS 1998; 12:1815-1822.
5. Boulware DR, Callens S, Pahwa S. Pediatric HIV immune reconstitution inflammatory syndrome. Curr Opin HIV AIDS 2008; 3:461-467.
6. Murdoch DM, Venter WD, Van Rie A, Feldman C. Immune Reconstitution Syndrome (IRIS): review article of common infectious manifestations and treatment options. AIDS Res Therapy 2007; 4:9.
7. Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC Jr, et al. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 2005; 19:399-406.
8. Puthanakit T, Aurpibul L, Oberdorfer P, Akarathum N, Kanja-nanit S, Wannarit P, et al. Hospitalization and mortality among HIV-infected children after receiving highly active antiretro-viral therapy. Clin Infect Dis 2007; 44:599-604.
9. Puthanakit T, Oberdorfer P, Akarathum N, Wannarit P, Siri-santhana T, Sirisanthana V. Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children. Pediatr Infect Dis J 2006; 25:53-58.
10. Bakeera-Kitaka S, Kekitiinwa A, Dhabangi A, Namulema E, Maganda A, Boulware DR. Tuberculosis immune reconstitu-tion inflammatory syndrome among Ugandan children. Int J Infect Dis 2008; 12:e63-e64.
11. John L, Baalwa J, Kalimugogo P, Nabankema E, Castelnuovo B, Muhindo G, et al. Response to 'Does immune reconstitution promote active tuberculosis in patients receiving highly active antiretroviral therapy?'. AIDS 2005; 19:2049-2050.
12. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, et al. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatr 2007; 7:13.
13. Achan J, Ruel T, Kateera F, Kalyango J, Akello C, Gasasira A, et al. Immune reconstitution inflammatory syndrome in the first 6 months of antiretroviral therapy in HIV-infected Ugandan children [abstract #MOPDB105]. 17th International AIDS Conference; 8 August 2009; Mexico City, Mexico; 2009.
14. French MA, Price P, Stone SF. Immune restoration disease after antiretroviral therapy. AIDS 2004; 18:1615-1627.
15. Wang ME, Castillo ME, Montano SM, Zunt JR. Immune recon-stitution inflammatory syndrome in human immunodeficiency virus-infected children in Peru. Pediatr Infect Dis J 2009; 28:900-903.
16. Haddow LJ, Easterbrook PJ, Mosam A, Khanyile NG, Parboosing R, Moodley P, Moosa MY. Defining immune reconstitution inflammatory syndrome: evaluation of expert opinion versus 2 case definitions in a South African cohort. Clin Infect Dis 2009; 49:1424-1432.
17. Sharland M, Watkins AM, Dalgleish AG, Cammack N, Westby M. Immune reconstitution in HAART-treated children with AIDS. Highly active antiretroviral therapy. Lancet 1998; 352:577-578.
18. Kambugu A, Meya DB, Rhein J, O'Brien M, Janoff EN, Ronald AR, et al. Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy. Clin Infect Dis 2008; 46:1694-1701.
19. Murdoch DM, Venter WD, Feldman C, Van Rie A. Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective study. AIDS 2008; 22:601-610.
20. Kumarasamy N, Chaguturu S, Mayer KH, Solomon S, Yepthomi HT, Balakrishnan P, et al. Incidence of immune reconstitution syndrome in HIV/TB-coinfected patients after initiation of generic antiretroviral therapy in India. J Acquir Immune Defic Syndr 2004; 37:1574-1576.
21. Cheng VC, Yuen KY, Chan WM, Wong SS, Ma ES, Chan RM. Immune restitution disease involving the innate and adaptive response. Clin Infect Dis 2000; 30:882-892.
22. Stone SF, Price P, French MA. Immune restoration disease: a consequence of dysregulated immune responses after HAART. Curr HIV Res 2004; 2:235-242.
23. Manosuthi W, Van Tieu H, Mankatitham W, Lueangniyomkul A, Ananworanich J, Avihingsanon A, et al. Clinical case definition and manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS 2009; 23:2467-2471.
24. Lawn SD, Myer L, Bekker LG, Wood R. Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa. AIDS 2007; 21:335-341.
25. Baalwa J, Mayanja-Kizza H, Kamya MR, John L, Kambugu A, Colebunders R. Worsening and unmasking of tuberculosis in HIV-1 infected patients after initiating highly active antiretro-viral therapy in Uganda. Afr Health Sci 2008; 8:190-195.
26. Smith K, Kuhn L, Coovadia A, Meyers T, Hu CC, Reitz C, et al. Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy. AIDS 2009; 23:1097-1107.
27. Ratnam I, Chiu C, Kandala NB, Easterbrook PJ. Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort. Clin Infect Dis 2006; 42:418-427.
28. Flynn PM, Rudy BJ, Douglas SD, Lathey J, Spector SA, Martinez J, et al. Virological and immunological outcomes after 24 weeks in HIV type-1 infected adolescents receiving HAART. J Infect Dis 2004; 190:271-279.
29. Robertson J, Meier M, Wall J, Ying J, Fichtenbaum CJ. Immune reconstitution syndrome in HIV: validating a case definition and identifying clinical predictors in persons initiating antire-troviral therapy. Clin Infect Dis 2006; 42:1639-1646.
30. Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, et al. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008; 359:2233-2244.