A novel aryl-hydrazide from the marine lichen Lichina pygmaea: Isolation, synthesis of derivatives, and cytotoxicity assays

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4582-4586

  Roullier, Catherine ^a   Chollet Krugler, Marylne ^a   Weghe, Pierre Van De ^a   Devehat, Franoise Lohézic Le ^a   Boustie, Joël ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Aryl hydrazide; Cytotoxic activity; Lichen; Lichina pygmaea; Pygmeine

Indexed keywords

CYTOTOXIC AGENT; ETOPOSIDE; GLUTAMIC ACID; HYDRAZIDE DERIVATIVE; LEVO GLUTAMIC ACID 5 [(2,4 DIMETHOXY PHENYL) HYDRAZIDE]; LEVO GLUTAMIC ACID 5 [(4 HYDROXYPHENYL) HYDRAZIDE]; N 2 (BENZYLOXYCARBONYL) LEVO GLUTAMIC ACID 1 (BENZYL ESTER) 5 [(2 BENZYLOXY PHENYL) HYDRAZIDE]; N 2 (BENZYLOXYCARBONYL) LEVO GLUTAMIC ACID 1 (BENZYL ESTER) 5 [(3 BENZYLOXY PHENYL) HYDRAZIDE]; N 2 (BENZYLOXYCARBONYL) LEVO GLUTAMIC ACID 1 (BENZYL ESTER) 5 [(4 BENZYLOXY PHENYL) HYDRAZIDE]; PHENYLHYDRAZINE; PYGMEINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; ISOMER; LICHENS; LICHINA PYGMAEA; MELANOMA; MELANOMA B16; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BENZYL COMPOUNDS; CELL LINE, TUMOR; GLUTAMIC ACID; HUMANS; HYDRAZINES; ISOMERISM; LICHENS; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR CONFORMATION; PHENYLHYDRAZINES;

LICHINA PYGMAEA; MURINAE;

EID: 77955413272     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.013     Document Type: Article

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