TOR and PKA pathways synergize at the level of the ste11 transcription factor to prevent mating and meiosis in fission yeast

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Valbuena, Noelia ^a   Moreno, Sergio ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR STE11; UNCLASSIFIED DRUG; PROTEIN KINASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; STE11 PROTEIN, S POMBE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE OVEREXPRESSION; MATING; MEIOSIS; MICROARRAY ANALYSIS; NONHUMAN; PROTEIN INTERACTION; QUANTITATIVE STUDY; SCHIZOSACCHAROMYCES POMBE; SEX DIFFERENTIATION; CELL CYCLE; DNA MICROARRAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL CYCLE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, FUNGAL; MEIOSIS; MICROSCOPY, FLUORESCENCE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 77955412229     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011514     Document Type: Article

References (29)

1. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (2005) Rheb binds and regulates the mTOR kinase. Curr Biol 15: 702-713.
2. Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG (2005) The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 280: 18717-18727.
3. Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457-468.
4. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptorindependent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302.
5. Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-1128.
6. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
7. Alvarez B, Moreno S (2006) Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci 119: 4475-4485.
8. Uritani M, Hidaka H, Hotta Y, Ueno M, Ushimaru T, et al. (2006) Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells 11: 1367-1379.
9. Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol 27: 3154-3164.
10. Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175: 1153-1162.
11. Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, et al. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12: 1357-1370.
12. Shabb JB (2001) Physiological substrates of cAMP-dependent protein kinase. Chem Rev 101: 2381-2411.
13. Smith FL, Lohmann AB, Dewey WL (1999) Involvement of phospholipid signal transduction pathways in morphine tolerance in mice. Br J Pharmacol 128: 220-226.
14. Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, et al. (2008) Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta 1784: 16-26.
15. DeVoti J, Seydoux G, Beach D, McLeod M (1991) Interaction between ran1+protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. Embo J 10: 3759-3768.
16. Yamawaki-Kataoka Y, Tamaoki T, Choe HR, Tanaka H, Kataoka T (1989) Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 86: 5693-5697.
17. Kawamukai M, Ferguson K, Wigler M, Young D (1991) Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regul 2: 155-164.
18. Sugimoto A, Iino Y, Maeda T, Watanabe Y, Yamamoto M (1991) Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev 5: 1990-1999.
19. Yamamoto M (1996) Regulation of meiosis in fission yeast. Cell Struct Funct 21: 431-436.
20. Kunitomo H, Higuchi T, Iino Y, Yamamoto M (2000) A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development. Mol Biol Cell 11: 3205-3217.
21. Higuchi T, Watanabe Y, Yamamoto M (2002) Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast. Mol Cell Biol 22: 1-11.
22. Moreno S, Klar A, Nurse P (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194: 795-823.
23. Bahler J, Wu JQ, Longtine MS, Shah NG, McKenzie A, 3rd, et al. (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14: 943-951.
24. Foiani M, Marini F, Gamba D, Lucchini G, Plevani P (1994) The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol 14: 923-933.
25. Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, et al. (2007) Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A 104: 3514-3519.
26. Maeda T, Watanabe Y, Kunitomo H, Yamamoto M (1994) Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J Biol Chem 269: 9632-9637.
27. Daga RR, Bolanos P, Moreno S (2003) Regulated mRNA stability of the Cdk inhibitor Rum1 links nutrient status to cell cycle progression. Curr Biol 13: 2015-2024.
28. Mata J, Bahler J (2006) Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast. Proc Natl Acad Sci U S A 103: 15517-15522.
29. Qin J, Kang W, Leung B, McLeod M (2003) Ste11p, a high-mobility-group box DNA-binding protein, undergoes pheromone- and nutrient-regulated nuclearcytoplasmic shuttling. Mol Cell Biol 23: 3253-3264.