Helicobacter pylori therapy in children: Overview and challenges

International Journal of Immunopathology and Pharmacology

Volumn 23, Issue 2, 2010, Pages 405-416

  Chiesa, Claudio ^a   Pacifico, L ^a,b   Anania, C ^b   Poggiogalle, E ^b   Chiarelli, F ^c   Osborn, J F ^b  

^a CNR   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

Children; Helicobacter pylori; Therapy

Indexed keywords

AMOXICILLIN; BISMUTH; BISMUTH CITRATE; CLARITHROMYCIN; METRONIDAZOLE; NITROIMIDAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROBIOTIC AGENT; PROTON PUMP INHIBITOR; RANITIDINE; SUCRALFATE; TINIDAZOLE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; BACTERIUM ADHERENCE; CLINICAL TRIAL; DRUG EFFICACY; DRUG TREATMENT FAILURE; DUODENUM ULCER; ERADICATION THERAPY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MEDLINE; NONHUMAN; PATIENT COMPLIANCE; PEPTIC ULCER; PRIORITY JOURNAL; RETREATMENT; REVIEW; TREATMENT RESPONSE;

EID: 77955409469     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201002300203     Document Type: Review

References (51)

1. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347:1175-86.
2. Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Macarthur C, Snyder J, Sherman PM; North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000; 31:490-7.
3. Queiroz DM, Moura SB, Mendes EN, Rocha GA, Barbosa AJA, de Carvalho AST. Effect of Helicobacter pylori eradication on G-cell and D-cell density in children. Lancet 1994; 343:1191-3.
4. Kato S, Takeyama J, Ebina K, Naganuma H. Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. Pediatrics 1997; 100:e3.
5. Walsh D, Goggin N, Rowland M, Durnin M, Moriarty S, Drumm B. One-week treatment for Helicobacter pylori infection. Arch Dis Child 1997; 76:352-5.
6. Casswall TH, Alfvén G, Drapinski M, Bergström M, Dahlström KA. One-week treatment with omeprazole, clarithromycin, and metronidazole in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 1998; 27:415-8.
7. Moshkowitz M, Reif S, Brill S, Ringel Y, Arber N, Halpern Z, Bujanover Y. One-week triple therapy with omeprazole, clarithromycin, and nitroimidazole for Helicobacter pylori infection in children and adolescents. Pediatrics 1998; 102:e14.
8. Kato S, Ritsuno H, Ohnuma K, Linuma K, Sugiyama T, Asaka M. Safety and efficacy of one-week triple therapy for eradicating Helicobacter pylori in children. Helicobacter 1998; 3:278-82.
9. Tirén U, Sandstedt B, Finkel Y. Helicobacter pylori gastritis in children: efficacy of 2 weeks of treatment with clarithromycin, amoxicillin and omeprazole. Acta Paediatr 1999; 88:166-8.
10. Kalach N, Raymond J, Benhamou PH, Bergeret M, Dupont C. Short-term treatment with amoxycillin, clarithromycin and lansoprazole during Helicobacter pylori infection in children. Clin Microbiol Infect 1999; 5:235-6.
11. Nijevitch AA, Farztdinov KM, Sataev VU, et al. Helicobacter pylori infection in childhood: results of management with ranitidine bismuth citrate plus amoxicillin and tinidazole. J Gastroenterol Hepatol 2000; 15:1243-50.
12. Shashidhar H, Peters J, Lin CH, Rabah R, Thomas R, Tolia V. A prospective trial of lansoprazole triple therapy for pediatric Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 2000; 30:276-82.
13. Ozen H, Dinier G, Akyon Y, Kocak N, Yuce A, Gurakan F. Helicobacter pylori infection and recurrent abdominal pain in Turkish children. Helicobacter 2001; 6:234-8.
14. Kocak N, Saltik IN, Ozen H, Yuce A, Gurakan F. Lansoprazole triple therapy for Turkish children with Helicobacter pylori infections. J Pediatr Gastroenterol Nutr 2001; 32:614.
15. Ozcay F, Kocak N, Temizel IN, Demir H, Ozen H, Yuce A, Gurakan F. Helicobacter pylori infection in Turkish children: comparison of diagnostic tests, evaluation of eradication rate, and changes in symptoms after eradication. Helicobacter 2004; 9:242-8.
16. Kato S, Konno M, Maisawa SI, et al. Results of triple eradication therapy in Japanese children: a retrospective multicenter study. J Gastroenterol 2004; 39:838-43.
17. Kawakami E, Machado RS, Ogata SK, Langner M, Fukushima E, Carelli AP, Bonucci C, Patricio FR. Furazolidone-based triple therapy for H.pylori gastritis in children. World J Gastroenterol 2006; 12:5544-9.
18. Nijevitch AA, Sataev VU, Akhmadeyeva EN, Arsamastsev AG. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter 2007; 12:132-5.
19. Gottrand F, Kalach N, Spyckerelle C, et al. Omeprazole combined with amoxicillin and clarithromycin in the eradication of Helicobacter pylori in children with gastritis: a prospective randomized double-blind trial. J Pediatr 2001; 139:664-8.
20. Cadranel S., Bontemps P, Van Biervliet S, Alliet P, Lauvau D, Vandenhoven G, Vandenplas Y. Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. Acta Paediatr 2007; 96:82-6.
21. Huang FC, Chang MH, Hsu HY, Lee PI, Shun CT. Long-term follow-up of duodenal ulcer in children before and after eradication of Helicobacter pylori. J Pediatr Gastroenterol Nutr 1999; 28:76-80.
22. Singh M, Prasad KN, Yachha SK, Saxena A, Krishnani N. Helicobacter pylori infection in children: prevalence, diagnosis and treatment outcome. Trans R Soc Trop Med Hyg 2006; 100:227-33.
23. Cucchiara S, Salvia G, Az-Zeqeh N, D'Armiento F, De Petra MR, Rapagiolo S, Campanozzi A, Emiliano M. Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism. Ital J Gastroenterol 1996; 28:430-5.
24. Behrens R, Lang T, Keller KM, et al. Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial. Arch Dis Child 1999; 81:68-70.
25. Shcherbakov PL, Filin VA, Volkov IA, Tatarinov PA, Belousov YB. A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers. J Int Med Res 2001; 29:147-53.
26. Bahremand S, Nematollahi LR, Fourutan H, Tirgari F, Nouripour S, Mir E, Aghakhani S. Evaluation of triple and quadruple Helicobacter pylori eradication therapies in Iranian children: A randomized clinical trial. Eur J Gastroenterol Hepatol 2006; 18:511-4.
27. Usta Y, Saltik-Temizel IN, Demir H, Uslu N, Ozen H, Gurakan F, Yuce A. Comparison of short- and long-term treatment protocols and the results of second-line quadruple therapy in children with Helicobacter pylori infection. J Gastroenterol 2008; 43:429-33.
28. Ashorn M, Rago T, Kokkonen J, Ruuska T, Rautelin H, Karikoski R. Symptomatic response to Helicobacter pylori eradication in children with recurrent abdominal pain. J Clin Gastroenterol 2004; 38:646-50.
29. Oderda G, Marinello D, Lerro P, et al. Dual vs. triple therapy for childhood Helicobacter pilori gastritis: a double-blind randomized multicenter trial. Helicobacter 2004; 9:293-301.
30. Vaira D, Zullo A, Vakil N, et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial. Ann Intern Med 2007; 146:556-63.
31. Jafri NS, Hornung CA, Howden CW. Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment. Ann Intern Med 2008; 148:923-31.
32. Gatta L, Vakil N, Leandro G, Di Mario F, Vaira D. Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol 2009; 104:3069-79.
33. Francavilla R, Lionetti E, Castellaneta SP, et al. Improved efficacy of 10-day sequential treatment for Helicobacter pylori eradication in children: A randomized trial. Gastroenterology 2005; 129:1414-9.
34. Lesbros-Pantoflickova D, Corthésy-Theulax I, Blum AL. Helicobacter pylori and probiotics. J Nutr 2007; 137(S):812-18.
35. Cruchet S, Obregon MC, Salazar G, Diaz E, Gotteland M. Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. Nutrition 2003; 19:716-21.
36. Sýkora J, Valecková K, Amlerová J, et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol 2005; 39:692-8.
37. Lionetti E, Miniello VL, Castellaneta SP, et al. Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Aliment Pharmacol Ther 2006; 24:1461-8.
38. Goldman CG, Barrado DA, Balcarce N, et al. Effect of a probiotic food as an adjuvant to triple therapy for eradication of Helicobacter pylori infection in children. Nutrition 2006; 22:984-8.
39. Szajewska H, Albrecht P, Topczewska-Cabanek A. Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. J Pediatr Gastroenterol Nutr 2009; 48:431-6.
40. Hurduc V, Plesca D, Dragomir D, Sajin M, Vandenplas Y. A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. Acta Paediatr 2009; 98:127-31.
41. Koletzko S, Richy F, Bontems P, et al. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 2006; 55:1711-6.
42. Mégraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 2004; 53:1374-84
43. Kalach N, Benhamou PH, Campeotto F, Bergeret M, Dupont C, Raymond J. Clarithromycin resistance and eradication of Helicobacter pylori in children. Antimicrob Agents Chemother 2001; 45:2134-5.
44. Arenz T, Antos D, Russmann H, Alberer M, Buderus S, Kappler M, Koletzko S. Esomeprazole-based 1-week triple therapy directed by susceptibility testing for eradication of Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr 2006; 43:180-4.
45. Faber J, Bar-Meir M, Rudensky B, et al. Treatment regimens for Helicobacter pylori infection in children: Is in vitro susceptibility testing helpful? J Pediatr Gastroenterol Nutr 2005; 40:571-4.
46. López-Brea M, Martínez MJ, Domingo D, Sánchez I, Alarcón T. Metronidazole resistance and virulence factors in Helicobacter pylori as markers for treatment failure in a paediatric population. FEMS Immunol Med Microbiol 1999; 24:183-8.
47. Sugimoto M, Yamaoka Y. Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy. Arch Immunol Ther Exp 2009; 57:45-56.
48. van Doorn LJ, Schneeberger PM, Nouhan N, Plaisier AP, Quint WG, de Boer WA. Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment. Gut 2000; 46:321-6.
49. Nijevitch AA, Shcherbakov PL, Sataev VU, Khasanov RS, Al Khashash R, Tuygunov MM. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy with nifuratel to furazolidone. Aliment Pharmacol Ther 2005; 22:881-7.
50. De Francesco V, Ierardi E, Hassan C, Zullo A. Furazolidone therapy for Helicobacter pylori: is it effective and safe? World J Gastroenterol 2009; 15:1914-5.
51. Dehghani SM, Erjaee A, Imanieh MH, Haghighat M. Efficacy of the standard quadruple therapy versus triple therapies containing proton pump inhibitor plus amoxicillin and clarithromycin or amoxicillin-clavulanic acid and metronidazole for Helicobacter pylori eradication in children. Dig Dis Sci 2009; 54:1720-4.