Oppositinines A and B: New vasorelaxant β-carboline alkaloids from Neisosperma oppositifolia

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 8, 2010, Pages 1085-1087

  Ahmad, Kartini ^a   Thomas, Noel F ^b   Hadi, A Hamid A ^b   Mukhtar, Mat Ropi ^b   Mohamad, Khalit ^b   Nafiah, Mohd Azlan ^a   Takeya, Koichi ^c   Morita, Hiroshi ^d   Litaudon, Marc ^e   Arai, Hiroko ^d   Awang, Khalijah ^b  

^a SULTAN IDRIS EDUCATION UNIVERSITY   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d HOSHI UNIVERSITY   (Japan)

^e CNRS   (France)

Author keywords

carboline; Apocynaceae; Indole; Neisosperma oppositifolia; Vasorelaxant activity

Indexed keywords

10 METHOXYDIHYDROCORYNANTHEOL N OXIDE; ALKALOID DERIVATIVE; BETA CARBOLINE DERIVATIVE; ISOCARAPANAUBINE; ISORESERPILINE; OCHROPPOSININE OXINDOLE; OPPOSITININE A; OPPOSITININE B; UNCLASSIFIED DRUG; VASODILATOR AGENT; VOBASINE;

ANIMAL TISSUE; ARTICLE; BARK; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENCY; ELECTROSPRAY MASS SPECTROMETRY; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; NEISOSPERMA OPPOSITIFOLIA; NONHUMAN; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY; VASODILATATION;

ANIMALS; AORTA; APOCYNACEAE; CARBOLINES; MALE; MOLECULAR STRUCTURE; NITRIC OXIDE; PLANT EXTRACTS; PLANT STEMS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; STEREOISOMERISM; VASODILATOR AGENTS;

EID: 77955405513     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.1085     Document Type: Article

References (23)

1. Parris B. S., Latiff A., Mal. Nat. J., 50, 12-45 (1997).
2. Goh S. H., Razak A. M. A., Wong W. H., Tetrahedron, 45, 7899-7920 (1989).
3. Kam T. S., Yoganathan K., Mok S. L., Phytochemistry, 46, 789-792 (1997).
4. Abraham D. J., Rosenstein, R. D., Lyon, R. L., Fong, H. S., Tetrahedron Lett., 1972, 909-912 (1972).
5. Thoison O., Guénard D., Sevenet T., Kan-Fan C., Quirion J. C., Husson J. P., Deverre J. R., Chan K. C., Potier P., C. R. Acad. Sci., Paris II, 304, 157 (1987).
6. Morita H., Awang K., Hadi A. H. A., Takeya K., Itokawa H., Kobayashi J., Bioorg. Med. Chem. Lett., 15, 1045-1050 (2005).
7. Awang K., Lim C. S., Mohamad K., Morita H., Hirasawa Y., Takeya K., Thoison O., Hadi A. H. A., Bioorg. Med. Chem., 15, 5997-6002 (2007).
8. http://www.efloras.org/florataxon.aspx?flora-id=122595. [cited 11 September 2008].
9. Ahond A., Fernandez H., Julia-Moore M., Poupat C., Sanchez V., Potier P., J. Nat. Prod., 44, 193-199 (1981).
10. Fosberg F. R., Boiteau P., Sachet M. H., Adansonia, 17, 23 (1977).
11. Awang K., Ahmad K., Thomas N. F., Hirasawa Y., Takeya K., Hadi A. H. A., Mukhtar M. R., Mohamad K., Morita H., Heterocycles, 75, 3051-3056 (2008).
12. Awang K., Thoison O., Hamid A. H. A., Pais M., Sevenet T., Nat. Prod. Lett., 3, 283-289 (1993).
13. Gunatilaka A. A. L., Fernando H. C., Atta-ur-Rahman, Qureshi M. M., Balasubramaniam S., Heterocycles, 28, 999-1005 (1989).
14. Douglas B., Kirkpatrick J. L., Moore B. P., Weisbach J. A., Aust. J. Chem., 17, 246-255 (1964).
15. Clivio P., Richard B., Hamid A. H., David B., Sevenet T., Zeches M., Men-Oliver L. L., Phytochemistry, 29, 3007-3011 (1990).
16. Gözler B., Shamma M., J. Nat. Prod., 53, 740-743 (1990).
17. Silverstein R. M., Webster F. X., "Spectrometric Identification of Organic Compounds," 6th ed., John Wiley & Sons, New York, 1996, pp. 92-93.
18. Seki H., Tokunaga T., Utsumi H., Yamaguchi K., Tetrahedron, 56, 2935-2939 (2000).
19. Gözler T., Gözler B., Linden A., Hesse M., Phytochemistry, 43, 1425-1426 (1996).
20. Batchily F., Mehri H., Plat M., Sevenet T., Annales Pharmaceutiques Francaises, 43, 513-520 (1986).
21. Morita H., Iizuka T., Choo C. Y., Chan K. L., Takeya K., Kobayashi J., Bioorg. Med. Chem. Lett., 16, 4609-4611 (2006).
22. McNeill J. R., Jurgens T. M., Can. J. Physiol. Pharmacol., 84, 803-821 (2006).
23. Shi C. C., Liao J. F., Chen C. F., Jpn. J. Pharmacol., 85, 299-305 (2001).