Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry

Carcinogenesis

Volumn 31, Issue 8, 2010, Pages 1412-1416

  Jacobs, Elizabeth T ^a   Martínez, Maria E ^a   Campbell, Peter T ^b   Conti, David V ^c   Duggan, David ^d   Figueiredo, Jane C ^c   Haile, Robert W ^c   LeRoy, Elizabeth C ^a   Poynter, Jenny N ^c,e   Thompson, Patricia A ^a   Baron, John A ^f  

^a UNIVERSITY OF ARIZONA   (United States)

^b AMERICAN CANCER SOCIETY   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; RETINOID X RECEPTOR; TUMOR MARKER; VITAMIN D RECEPTOR;

ADULT; ALLELE; ARTICLE; CANCER REGISTRY; CANCER RISK; CASR GENE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; RECEPTOR GENE; RXRA GENE; SINGLE NUCLEOTIDE POLYMORPHISM; VDR GENE;

CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FAMILY; FEMALE; GENETIC VARIATION; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MICROSATELLITE INSTABILITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCIUM-SENSING; REGISTRIES; RETINOID X RECEPTORS; RISK FACTORS;

EID: 77955367456     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq127     Document Type: Article

References (43)

1. Davis,C.D. (2008) Vitamin D and cancer: current dilemmas and future research needs. Am. J. Clin. Nutr., 88, 565S-569S.
2. Holt,P.R. (2008) New insights into calcium, dairy and colon cancer. World J. Gastroenterol., 14, 4429-4433.
3. Jacobs,E.T. et al. (2005) Vitamin D activity and colorectal neoplasia: a pathway approach to epidemiologic studies. Cancer Epidemiol. Biomarkers Prev., 14, 2061-2063.
4. Poynter,J.N.J. et al. Genetic variation in the vitamin D receptor (VDR) and the vitamin D binding protein (GC) and risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol. Biomarkers Prev., 19, 525-536.
5. Fan,Y.Y. et al. (2003) Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. Carcinogenesis, 24, 1541-1548.
6. Albrechtsson,E. et al. (2002) The expression of retinoic acid receptors and the effects in vitro by retinoids in human pancreatic cancer cell lines. Pancreas, 25, 49-56.
7. Jiang,S.Y. et al. (1999) Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization. Br. J. Cancer, 80, 206-214.
8. Howe,L.R. (2007) Rexinoids and breast cancer prevention. Clin. Cancer Res., 13, 5983-5987.
9. Chawla,A. et al. (2001) Nuclear receptors and lipid physiology: opening the X-files. Science, 294, 1866-1870.
10. Haussler,M.R. et al. (2008) Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr. Rev., 66, S98-S112.
11. Egan,J.B.T. et al. Genetic variation in VDR and RXR and risk for colorectal adenoma recurrence. Cancer Res., 70, 1496-1504.
12. Canaff,L. et al. (2002) Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxy vitamin D. J. Biol. Chem., 277, 30337-30350.
13. Dong,L.M. et al. (2008) Genetic variation in calcium-sensing receptor and risk for colon cancer. Cancer Epidemiol. Biomarkers Prev., 17, 2755-2765.
14. Baron,J.A. et al. (1999) Calcium supplements for the prevention of colorectal adenomas. N. Engl. J. Med., 340, 101-107.
15. Saidak,Z. et al. (2009) The role of the calcium-sensing receptor in the development and progression of cancer. Endocr. Rev., 30, 178-195.
16. Bacsi,K. et al. (2008) Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population. BMC Cancer, 8, 317.
17. Speer,G. et al. (2002) Calcium-sensing receptor A986S polymorphism in human rectal cancer. Int. J. Colorectal Dis., 17, 20-24.
18. Newcomb,P.A. et al. (2007) Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol. Biomarkers Prev., 16, 2331-2343.
19. Poynter,J.N. et al. (2008) Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mis-match repair germline mutation screening. Cancer Epidemiol. Biomarkers Prev., 17, 3208-3215.
20. (2003) The International HapMap Project. Nature, 426, 789-796.
21. de Bakker,P.I. et al. (2005) Efficiency and power in genetic association studies. Nat. Genet., 37, 1217-1223.
22. Gauderman,W.J. et al. (2007) Testing association between disease and multiple SNPs in a candidate gene. Genet. Epidemiol., 31, 383-395.
23. Conneely,K.N. et al. (2007) So many correlated tests, so little time! rapid adjustment of P values for multiple correlated tests. Am. J. Hum. Genet., 81, 1158-1168.
24. Mickey,R.M. et al. (1989) The impact of confounder selection criteria on effect estimation. Am. J. Epidemiol., 129, 125-137.
25. Xiao,J.H. et al. (2003) Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J. Biol. Chem., 278, 29954-29962.
26. Dillard,A.C. et al. (2008) Retinol increases beta-catenin-RXRalpha binding leading to the increased proteasomal degradation of beta-catenin and RXRalpha. Nutr. Cancer, 60, 97-108.
27. Cesario,R.M. et al. (2006) Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. Cancer Lett., 240, 225-233.
28. Kane,K.F. et al. (1996) Antiproliferative responses to two human colon cancer cell lines to vitamin D3 are differently modified by 9-cis-retinoic acid. Cancer Res., 56, 623-632.
29. ElSharawy,A. et al. (2006) SNPSplicer: systematic analysis of SNPdependent splicing in genotyped cDNAs. Hum. Mutat., 27, 1129-1134.
30. Fujimaru,M. et al. (1998) Two mutations remote from an exon/intron junction in the beta-hexosaminidase beta-subunit gene affect 3'-splice site selection and cause Sandhoff disease. Hum. Genet., 103, 462-469.
31. Webb,K.E. et al. (2003) The 4830C>A polymorphism within intron 5 affects the pattern of alternative splicing occurring within exon 6 of the thrombopoietin gene. Exp. Hematol., 31, 488-494.
32. Yamazaki,K. et al. (2007) Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells-phosphorylated RXR alpha is a critical target for colon cancer management. Gut, 56, 1557-1563.
33. Fedirko,V. et al. (2009) Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial. Cancer Epidemiol. Biomarkers Prev., 18, 2933-2941.
34. Fedirko,V. et al. (2009) Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: a randomized, doubleblind, placebo-controlled clinical trial. Cancer Prev. Res, 2, 213-223.
35. Jacobs,E.T. et al. (2007) Diet, gender, and colorectal neoplasia. J. Clin. Gastroenterol., 41, 731-746.
36. Su,W. et al. (2007) Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon. Physiol. Genomics, 30, 342-353.
37. Gervaz,P. et al. (2004) Two colons-two cancers: paradigm shift and clinical implications. J. Surg. Oncol., 88, 261-266.
38. Grady,W.M. et al. (2008) Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology, 135, 1079-1099.
39. Um,S. et al. (1998) Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. J. Biol. Chem., 273, 20728-20736.
40. Fuszek,P. et al. (2004) Relationship between serum calcium and CA 19-9 levels in colorectal cancer. World J. Gastroenterol., 10, 1890-1892.
41. Jenab,M. et al. (2009) Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiol. Biomarkers Prev., 18, 2485-2491.
42. Ahn,J. et al. (2009) Vitamin D-related genes, serum vitamin D concentrations, and prostate cancer risk. Carcinogenesis, 30, 769-776.
43. Chang,S.C. et al. (2008) Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. Carcinogenesis, 29, 944-948.