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[8a]
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58
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77955387771
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[4a]), desired coupling product 3a was only formed in small amounts (10-17%), and 4 was the major isolated product. (50-55%)
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[4a]), desired coupling product 3a was only formed in small amounts (10-17%), and 4 was the major isolated product. (50-55%).
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77955409302
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+-mediated reaction between 1a and 2a, 3a was still formed but in a moderate 40 % yield. This result is also consistent with the proposed, ionic mechanism, as phenols can also react with TEMPO salts. However, a radical pathway cannot be completely ruled out on the basis of these observations
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+-mediated reaction between 1a and 2a, 3a was still formed but in a moderate 40 % yield. This result is also consistent with the proposed, ionic mechanism, as phenols can also react with TEMPO salts. However, a radical pathway cannot be completely ruled out on the basis of these observations.
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66
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77955354088
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Highly unstable TEMPOH was partially oxidized to TEMPO during manipulation of the GC-MS samples in air
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Highly unstable TEMPOH was partially oxidized to TEMPO during manipulation of the GC-MS samples in air.
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77955359334
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The use of other strong organic acids such as TfOH or AcOIi led to undesired products and/or large amounts of isochromanone (4)
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The use of other strong organic acids such as TfOH or AcOIi led to undesired products and/or large amounts of isochromanone (4).
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71
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77955374952
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This metal-free reaction was not efficient for tetrahydroisoquinolines, which were not tolerated (lg) or led to complex mixtures (1J, 19% 3r after 48 h)
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This metal-free reaction was not efficient for tetrahydroisoquinolines, which were not tolerated (lg) or led to complex mixtures (1J, 19% 3r after 48 h).
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