Process research and development of a MTP inhibitor: Another case of disappearing polymorphs upon scale-up

Organic Process Research and Development

Volumn 14, Issue 4, 2010, Pages 878-882

  Prashad, Mahavir ^a   Sutton, Paul ^a   Wu, Raeann ^a   Hu, Bin ^a   Vivelo, James ^a   Carosi, Joseph ^a   Kapa, Prasad ^a   Liang, Jessica ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLIZATION PROCESS; DEVELOPMENT STAGES; DRUG SUBSTANCES; FURTHER DEVELOPMENT; IMPURITY PROFILE; LDL CHOLESTEROL; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEINS; POLYMORPHIC FORMS; RESEARCH AND DEVELOPMENT; SCALE-UP; STABLE FORM; SYNTHESIS ROUTE;

PILOT PLANTS;

SYNTHESIS (CHEMICAL);

EID: 77955364202     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100115u     Document Type: Article

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