Superparamagnetic iron oxide nanoparticles labeling of bone marrow stromal (Mesenchymal) cells does not affect their "sternness"

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Balakumaran, Arun ^a   Pawelczyk, Edyta ^b   Ren, Jiaqiang ^b   Sworder, Brian ^a   Chaudhry, Aneeka ^b   Sabatino, Marianna ^b   Stroncek, David ^b   Frank, Joseph A ^b,c   Robey, Pamela G ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD146 ANTIGEN; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; MAGNETITE; NANOPARTICLE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL LABELING; CELL POPULATION; CELL RENEWAL; COLONY FORMATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GOLD STANDARD; HEMATOPOIETIC STEM CELL; HOST CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; PERICYTE; STROMA CELL; ANIMAL; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING;

MUS;

ANIMALS; ANTIGENS, CD146; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; FERROSOFERRIC OXIDE; GENE EXPRESSION PROFILING; HUMANS; MAGNETIC RESONANCE IMAGING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; NANOPARTICLES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 77955362037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011462     Document Type: Article

References (25)

1. Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, et al. (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 104: 1217-1223.
2. Frank JA, Anderson SA, Kalish H, Jordan EK, Lewis BK, et al. (2004) Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging. Cytotherapy 6: 621-625.
3. Anderson SA, GlodJ, Arbab AS, Noel M, Ashari P, et al. (2005) Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovascu-lature in a glioma model. Blood 105: 420-425.
4. Arbab AS, Pandit SD, Anderson SA, Yocum GT, Bur M, et al. (2006) Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis. Stem Cells 24: 671-678.
5. de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van KriekenJH, et al. (2005) Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 23: 1407-1413.
6. Zhu J, Zhou L, XingWu F (2006) Tracking neural stem cells in patients with brain trauma. N EnglJ Med 355: 2376-2378.
7. Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, et al. (2004) MRI detection of single particles for cellular imaging. Proc Natl Acad Sci USA 101: 10901-10906.
8. Arbab AS, Jordan EK, Wilson LB, Yocum GT, Lewis BK, et al. (2004) In vivo trafficking and targeted delivery of magnetically labeled stem cells. Hum Gene Ther 15: 351-360.
9. Pawelczyk E, Arbab AS, Pandit S, Hu E, Frank JA (2006) Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling ofcells: implications for cellular magnetic resonance imaging. NMR Biomed 19: 581-592.
10. Arbab AS, Yocum GT, Rad AM, Khakoo AY, Fellowes V, et al. (2005) Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells. NMR Biomed 18: 553-559.
11. Kostura L, Kraitchman DL, Mackay AM, Pittenger MF, Bulte JW (2004) Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed 17: 513-517.
12. Bianco P, Kuznetsov SA, Riminucci M, Gehron Robey P (2006) Postnatal skeletal stem cells. Methods Enzymol 419: 117-148.
13. Bianco P, Robey PG, Simmons PJ (2008) Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2: 313-319.
14. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, et al. (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hemato-poietic microenvironment. Cell 131: 324-336.
15. Stroncek DF, Jin P, Wang E, Ren J, Sabatino M, Marincola FM (2009) Global transcriptional analysis for biomarker discovery and validation in cellular therapies. Mol Diagn Ther 13: 181-193.
16. Kuznetsov SA, Krebsbach PH, Satomura K, Kerr J, Riminucci M, et al. (1997) Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res 12: 1335-1347.
17. Westen H, Bainton DF (1979) Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors. J Exp Med 150: 919-937.
18. Lee ES, Chan J, Shuter B, Chong MS, Ramachandra DL, et al. (2009) Microgel Iron Oxide Nanoparticles for Tracking Human Fetal Mesenchymal Stem Cells Through Magnetic Resonance Imaging. Stem Cells 27: 1921-1931.
19. Osawa M, Hanada K, Hamada H, Nakauchi H (1996) Long-term lymphohe-matopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273: 242-245.
20. Spangrude GJ, Heimfeld S, Weissman IL (1988) Purification and characterization of mouse hematopoietic stem cells. Science 241: 58-62.
21. Weissman IL (2000) Stem cells: units ofdevelopment, units ofregeneration, and units in evolution. Cell 100: 157-168.
22. Krebsbach PH, Kuznetsov SA, Satomura K, Emmons RV, Rowe DW, Robey PG (1997) Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation 63: 1059-1069.
23. Mankani MH, Kuznetsov SA, Avila NA, Kingman A, Robey PG (2004) Bone formation in transplants of human bone marrow stromal cells and hydroxyap-atite-tricalcium phosphate: prediction with quantitative CT in mice. Radiology 230: 369-376.
24. Wang E, Miller LD, Ohnmacht GA, Liu ET, Marincola FM (2000) High-fidelity mRNA amplification for gene profiling. Nat Biotechnol 18: 457-459.
25. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 95: 14863-14868.