An aromatic prenyltransferase-like gene HlPT-1 preferentially expressed in lupulin glands of hop

Plant Biotechnology

Volumn 27, Issue 2, 2010, Pages 199-204

  Tsurumaru, Yusuke ^a   Sasaki, Kanako ^a   Miyawaki, Tatsuya ^a   Momma, Takayuki ^b   Umemoto, Naoyuki ^b   Yazaki, Kazufumi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KIRIN HOLDINGS CO LTD   (Japan)

Author keywords

Aromatic prenyltransferase; Bitter acids; Humulus lupulus; Trichome; Xanthohumol

Indexed keywords

EID: 77955338634     PISSN: 13424580     EISSN: 13476114     Source Type: Journal    
DOI: 10.5511/plantbiotechnology.27.199     Document Type: Article

References (22)

1. Akashi T, Sasaki K, Aoki T, Ayabe S, Yazaki K (2009) Molecular cloning and characterization of a cDNA for pterocarpan 4-dimethylallyltransferase catalyzing the key prenylation step in the biosynthesis of glyceollin, a soybean phytoalexin. Plant Physiol 149: 683-693
2. Cleemput MV, Cattor Ko, Bosscher KD, Haegeman G, Keukeleire DD, Heyerick A (2009) Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. J Nat Prod 72: 1220-1230
3. Collakova E, DellaPenna D (2003) Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Plant Physiol 131: 632-642
4. Gerhäuser C (2005) Beer constituents as potential cancer chemopreventive agents. Eur J Cancer 41: 1941-1954
5. Gerhäuser C (2005) Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites. Mol Nutr Food Res 49: 827-831
6. Heide L (2009) Prenyl transfer to aromatic substrates: genetics and enzymology. Curr Opin Chem Biol 13: 171-179
7. Keukeleire JD, Ooms G, Heyeric A, Roland-Ruiz I, Bockstaele EV, Keukeleire DD (2003) Formation and accumulation of α-acids, β-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.). J Agric Food Chem 51: 4436-4441
8. Lee Y, Moon SJ, Montell C (2009) Multiple gustatory receptors required for the caffeine response in Drosophila. Proc Natl Acad Sci USA 106: 4495-4500
9. Milligan SR, Kalita JC, Pocock V, Kauter VD, Stevens JF, Deinzer ML, Rong H, Keukeleire DD (2000) The endocrine activites of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 85: 4912-4915
10. Miranda CL, Aponso GLM, Stevens JF, Deinzer ML, Buhler DR (2000) Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett 149: 21-29
11. Nagel J, Culley LK, Lu Y, Liu E, Matthews PD, Stevens JF, Page JE (2008) EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20: 186-200
12. Okada Y, Ito K (2001) Cloning and analysis of valerophenone synthase gene expressed specifically in lupulin gland of Hop (Humulus lupulus L.). Biosci Biotechnol Biochem 65: 150-155
13. Sasaki K, Mito K, Ohara K, Yamamoto H, Yazaki K (2008) Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens. Plant Physiol 146: 1075-1084
14. Stevens JF, Taylor AW, Nickerson GB, Ivancic M, Henning J, Haunold A, Deinzer ML (2000) Prenylfavonoid variation in Humulus lupulus: distribution and taxonomic significance of xanthogalenol and 4'-O-methylxanthohumol. Phytochem 53: 759-775
15. Stevens JF, Page JE (2004) Xanthohumol and related prenylflavonoids from hops and beer: to your good health. Phytochem 65: 1317-1330
16. Wang G, Dixon RA (2009) Heterodimeric geranyl (geranyl) diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. Proc Natl Acad Sci USA 106: 9914-9919
17. Wang G, Tian Li, Aziz N, Broun P, Dai X, He J, King A, Zhao PX, Dixon RA (2008) Terpene biosynthesis in glandular trichomes of hop. Plant Physiol 148: 1254-1266
18. Wipf D, Benjdia M, Rikirsch E, Zimmermann S, Tegeder M, Frommer WB (2003) An expression cDNA library for suppression cloning in yeast mutants, complementation of a yeast his4 mutant, and EST analysis from the symbiotic basidiomycete Hebeloma cylindrosporum. Genome 46: 177-181
19. Yazaki K, Kunihisa M, Fujisaki T, Sato F (2002) Geranyl diphosphate: 4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. J Biol Chem 277: 6240-6246
20. Yazaki K, Sasaki K, Tsurumaru Y (2009) Prenylation of aromatic compounds, a key diversification of plant secondary metabolites. Phytochem 70: 1739-1745
21. Zanoli P, Zavatti M (2008) Pharmacognositc and pharmacological profile of Humulus lupulus L. J Ethnopharmacol 116: 383-396
22. Zuurbier KWM, Fung SY, Scheffer JJC, Verpoorte R (1995) Formation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus. Phytochem 38: 77-82