Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: From molecular modeling to in vivo evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5400-5412

  Brillouet, Séverine ^a,d   Dorbes, Sandra ^a   Courbon, Frédéric ^a,d,e   Picard, Claude ^c   Delord, Jean Pierre ^d   Benoist, Eric ^c   Poirot, Marc ^a,b   Mestre Voegtlé, Béatrice ^a,c   Silvente Poirot, Sandrine ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c Université Paul Sabatier Toulouse III   (France)

^d INSTITUT CLAUDIUS REGAUD   (France)

^e CHU RANGUEIL   (France)

Author keywords

111Indium; Cancer; Gastrin receptor; Metal chelate; Metal conjugate; SPECT

Indexed keywords

BIPYRIDINE CHELATING AGENT DI(6 AMINOHEXANOIC ACID) CHOLECYSTOKININ TETRAPEPTIDE IN 111 CONJUGATE; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ DERIVATIVE; CYCLOHEXYLDIETHYLENETRIAMINEPENTAACETIC ACID TETRAGASTRIN IN 111; GASTRIN; GASTRIN RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRAFT; CELL STRAIN 3T3; CELL STRAIN COS1; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SPECIFICITY; DRUG SYNTHESIS; INTERNALIZATION; ISOTOPE LABELING; LIGAND BINDING; MOUSE; NONHUMAN; RADIOISOTOPE DISTRIBUTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION; TUMOR SCINTISCANNING;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; NEOPLASMS; NIH 3T3 CELLS; OLIGOPEPTIDES; PENTETIC ACID; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; RECEPTOR, CHOLECYSTOKININ B;

EID: 77955337351     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.031     Document Type: Article

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