Effects of antihypertensive treatment after acute stroke in the Continue Or Stop post-Stroke Antihypertensives Collaborative Study (COSSACS): A prospective, randomised, open, blinded-endpoint trial

The Lancet Neurology

Volumn 9, Issue 8, 2010, Pages 767-775

  Robinson, Thompson G ^a   Potter, John F ^b   Ford, Gary A ^c   Bulpitt, Christopher J ^d   Chernova, Julia ^a   Jagger, Carol ^a,c   James, Martin A ^e   Knight, Joanne ^f   Markus, Hugh S ^g   Mistri, Amit K ^a   Poulter, Neil R ^d  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^f Stroke Association   (United Kingdom)

^g ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ACUTE DISEASE; ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; BARTHEL INDEX; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; SCORING SYSTEM; STROKE; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; UNITED KINGDOM;

AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; COOPERATIVE BEHAVIOR; ENDPOINT DETERMINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; STROKE; TREATMENT OUTCOME;

EID: 77955316852     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(10)70163-0     Document Type: Article

References (34)

1. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. Lancet 1997, 349:1569-1581. International Stroke Trial Collaborative Group.
2. CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997, 349:1641-1649. CAST (Chinese Acute Stroke Trial) Collaborative Group.
3. Willmot M, Leonardi-Bee J, Bath PM High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension 2004, 43:18-24.
4. Tikhonoff V, Zhang H, Richart T, Staessen JA Blood pressure as a prognostic factor after acute stroke. Lancet Neurol 2009, 8:938-948.
5. Fodstad H, Kelley PJ, Buchfelder M History of the Cushing reflex. Neurosurgery 2006, 59:1132-1137.
6. Chamorro A, Amaro S, Vargas M, et al. Catecholamines, infection, and death in acute ischemic stroke. J Neurol Sci 2007, 252:29-35.
7. Robinson TG, James M, Youde J, Panerai R, Potter J Cardiac baroreceptor sensitivity is impaired after acute stroke. Stroke 1997, 28:1671-1676.
8. Ohwaki K, Yano E, Nagashima H, Hirata M, Nakagomi T, Tamura A Blood pressure management in acute intracerebral hemorrhage: relationship between elevated blood pressure and hematoma enlargement. Stroke 2004, 35:1364-1367.
9. Britton M, Carlsson A, de Faire U Blood pressure course in patients with acute stroke and matched controls. Stroke 1986, 17:861-864.
10. Qureshi AI Acute hypertensive response in patients with stroke: pathophysiology and management. Circulation 2008, 118:176-187.
11. Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 2002, 33:1315-1320. for the IST Collaborative Group.
12. Schrader J, Luders S, Kulschewski A, et al. The ACCESS Study. Evaluation of acute candesartan cilexetil therapy in stroke survivors. Stroke 2003, 34:1699-1703.
13. Anderson CS, Huang Y, Wang JG, et al. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol 2008, 7:391-399.
14. Potter JF, Robinson TG, Ford GA, et al. Controlling Hypertension and Hypotension Immediately Post-Stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. Lancet Neurol 2009, 8:48-56.
15. Bath PMW, Martin RH, Palesch Y, et al. Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis. Stroke 2009, 40:3541-3546.
16. Geeganage C, Bath PMW Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev 2008, 4. CD000039.
17. Vasoactive drugs for acute stroke. Cochrane Database Syst Rev 2000, 4. Blood pressure in Acute Stroke Collaboration, CD002839.
18. Bath P, Chalmers J, Powers W, et al. International Society of Hypertension (ISH): statement on the management of blood pressure in acute stroke. J Hypertens 2003, 21:665-672.
19. Broderick J, Connolly S, Feldmann E, et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults-2007 update; a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007, 38:2001-2023.
20. Adams HP, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke; a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary working groups. Circulation 2007, 115:e478-e534.
21. Stroke: national clinical guideline for diagnosis and initial management of acute stroke and transient ischaemic attack (TIA) 2008, National Collaborating Centre for Chronic Conditions, Royal College of Physicians, London, UK, (accessed April 1, 2010). http://www.rcplondon.ac.uk/pubs/brochure.aspx?e=254.
22. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008, 25:457-507. The European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee.
23. COSSACS (Continue or Stop post-Stroke Antihypertensives Collaborative Study): rationale and design. J Hypertens 2005, 23:455-458. The COSSACS Trial Group.
24. Dennis M, Wellwood I, Warlow C Are simple questions a valid measure of outcome?. Cerebrovasc Dis 1997, 7:22-27.
25. Dorman P, Waddell F, Slattery J, Dennis M, Sandercock P Are proxy assessments of health status after stroke with the EuroQoL questionnaire feasible, accurate, and unbiased?. Stroke 1997, 28:1883-1887.
26. Geeganage CM, Bath PMW Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression. Hypertension 2009, 54:775-781.
27. Barber PA, Demchuk AM, Zhang J, Buchan AM Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 2000, 355:1670-1674.
28. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 2004, 363:439-445. Intravenous Magnesium Efficacy in Stroke (IMAGES) Study Investigators.
29. Sare GM, Gray LJ, Bath PMW Effect of antihypertensive agents on cerebral blood flow and flow velocity in acute ischaemic stroke: systematic review of controlled studies. J Hypertens 2008, 26:1058-1064.
30. National Sentinel Stroke Audit Organisational Audit 2009 Royal College of Physicians, (accessed April 1, 2010). http://www.rcplondon.ac.uk/media/Press-releases/Documents/Stroke-Organisational-Audit-2009.pdf.
31. Rothwell P, Warlow C Timing of transient ischaemic attacks preceding ischaemic stroke. Neurology 2005, 64:817-820.
32. Potter J, Mistri A, Brodie F, et al. Controlling Hypertension and Hypotension Immediately Post Stroke (CHHIPS)-a randomised controlled trial. Health Technol Assess 2009, 13:1-95.
33. Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily antihypertensive therapy in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Int J Stroke 2006, 1:245-249. The ENOS Investigators.
34. Delcourt C, Huang Y, Wang J, et al. The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2). Int J Stroke 2010, 5:110-116.